Evaluation of the serum prooxidant-antioxidant balance before and after vitamin D supplementation in adolescent Iranian girls

Timar, Ameneh; Saberi‐Karimian, Maryam; Ghazizadeh, Hamideh; Parizadeh, Seyed Mohammad Reza; Sabbaghzadeh, Reihaneh; Emadzadeh, Maryam; Eshaghi, Fatemeh; Tavallaie, Shima; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.1016/j.advms.2018.10.004

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…Total antioxidant capacity (TAC) is the estimated number of free radicals scavenged and used to estimate the antioxidant capacity of biological samples (25). Comparisons between the means of salivary parameters levels as a result of effect of Vitamin D3 treatment during the study period showed a significant rise in the means of the total antioxidant capacity on 21 st and 42 nd of the study period proving potential for pro and anti-oxidative effects of vitamin D3 (26) . This action of Vitamin D3 can be explained by the fact that vitamins are essential organic compounds that catalyze metabolic reactions as well as they also function as electron donors'…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effect of vitamin D-3 and its relation to salivary protein and oral health

Thanoon¹,

Al-Mashhadane²

2020

RDENTJ

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Aims:To investigate the antioxidant effects of vitamin D3 on oral health and to evaluate its effect on total salivary proteins in saliva. Materials and Methods: Forty patients were classified into two groups: Group 1: (20) chronic gingivitis patients, did not receive vitamin D3 (control group), Group 2: (20) chronic gingivitis patients (treatment group), received Vitamin D3 1000IU capsule. Scaling and polishing have been carried out for each volunteer to reach the base line for plaque index, gingival index, oral hygiene index and calculus index. In the next day, these indices were measured for all participants, then measured after 3 weeks then after 6 weeks from treatment. At the same visits, five milliliters of unstimulated saliva were collected for measurement of total salivary proteins and total antioxidant capacity. Results: there were significant reduction in oral health indices in 21st and 42nd days of the study which mean good response to treatment and improvement in gingival health. Conclusion: Vitamin D3 can be a good adjuvant in periodontal therapy

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Section: Discussionmentioning

confidence: 99%

Antioxidant effect of vitamin D-3 and its relation to salivary protein and oral health

Thanoon¹,

Al-Mashhadane²

2020

RDENTJ

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“…For it concerns the effect of vitamin D supplementation on biomarkers of oxidative stress/inflammation in healthy subjects, it is noteworthy that different biomarker profiles (e.g., total antioxidant capacity-TAC, glutathione, C reactive protein) improve, although for other parameters there is not a clear significant benefit (e.g., malondialdehyde-MDA and carbonyl groups) [ 184 , 185 , 186 , 187 , 188 ]. However, daily intake of vitamin D (150 mg of calcium + 500 IU vitamin D per 250 mL/12 weeks) significantly decreased serum protein carbonyl levels in healthy adults [ 189 ].…”

Section: Randomized Controlled Trialsmentioning

confidence: 99%

Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy

et al. 2023

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Beyond its key role in calcium homeostasis, vitamin D has been found to significantly affect the cardiovascular (CV) system. In fact, low vitamin D levels have been associated with increased CV risk, as well as increased CV morbidity and mortality. The majority of effects of this molecule are related directly or indirectly to its antioxidative and anti-inflammatory properties. Generally, vitamin D insufficiency is considered for 25-hydroxyvitamin D (25(OH)D) levels between 21–29 ng/mL (corresponding to 52.5–72.5 nmol/L), deficiency as 25(OH)D levels less than 20 ng/mL (<50 nmol/L), and extreme deficiency as 25(OH)D less than 10 ng/mL (<25 nmol/L). However, the definition of an optimal vitamin D status, as defined by 25(OH)D, remains controversial for many extra-bone conditions, including CV disease. In this review, confounding factors affecting the 25(OH)D measurement and status will be discussed. In particular, available evidence on the mechanism and role of vitamin D in relation to CV risk and disease through its antioxidant effect will also be reported, also facing the aspect regarding the debate on the minimum blood 25(OH)D level required to ensure optimal CV health.

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“…Similarly, we observed decreased TOS level and significantly increased TAS level in the DOX+VD group. This restorative effect of VD could be attributed to antioxidative utility of VD [11,12].…”

Section: Discussionmentioning

confidence: 92%

“…It is a membrane antioxidant, and includes Vitamin D 3 (cholecalciferol), 1,25dihydroxycholecalciferol, 7-dehydrocholesterol (pro-Vitamin D 3 ) and Vitamin D 2 (ergocalciferol) [11]. VD is both a prooxidative and antioxidative agent [12], and has been reported to reduce chronic inflammation, suppress oxidative stress, and contribute to mitochondrial respiratory function [13].…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin D on doxorubucin-induced lung injury and TRPM2 immunoreactivity in rats

Yalcin¹,

Türk²,

Aydın³

et al. 2020

Journal of Surgery and Medicine

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Aim: Although doxorubicin (DOX) is a commonly used chemotherapeutic agent, it causes significant toxic side effects on many organs. This study aims to investigate the effects of vitamin D (VD) on DOX-induced lung injury and expression of transient receptor potential melastatin 2 (TRPM2), a Ca 2 + permeable cation channel. Methods: A total of 24 Wistar albino rats were separated into four groups of six rats, as follows: The control group received no medications. The VD group received 200 IU/kg VD via an oral dropper (o.d.) for 14-days. DOX group received a single dose of 10 mg/kg DOX intraperitoneally (i.p.) on day 8. DOX+VD group was administered 200 IU/kg VD via an o.d. for 14-days, and a single dose of 10 mg/kg DOX i.p. on day 8. At the end of the experiment, lung and serum samples from all rats were collected. Masson's trichrome staining and streptavidin-biotin-peroxidase complex were applied to the lung tissue sections. Serum total antioxidant status (TAS) and total oxidant status (TOS) were assessed by enzyme-linked immunosorbent assay (ELISA) method. Results: Histopathological damage was observed in the DOX group compared to the control group, and biochemical and immunohistochemical evaluation revealed that TOS level and TRPM2 expression increased while TAS level decreased significantly (P<0.001). Additionally, compared to the DOX group VD administration significantly reversed these values in the DOX+VD group (P<0.001). Conclusion: VD showed a protective effect on lung damage induced by DOX. Our data also suggest that TRPM2 channel may have a role in the pathophysiology of DOX-induced lung damage.

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Evaluation of the serum prooxidant-antioxidant balance before and after vitamin D supplementation in adolescent Iranian girls

Cited by 15 publications

References 23 publications

Antioxidant effect of vitamin D-3 and its relation to salivary protein and oral health

Antioxidant effect of vitamin D-3 and its relation to salivary protein and oral health

Vitamin D Determinants, Status, and Antioxidant/Anti-inflammatory-Related Effects in Cardiovascular Risk and Disease: Not the Last Word in the Controversy

Effects of Vitamin D on doxorubucin-induced lung injury and TRPM2 immunoreactivity in rats

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