Evaluation of the social, clinical and laboratorial profile of patients diagnosed with leprosy in a reference center in São Paulo

Porto, Ana Carolina; Figueira, Renata Borges Fortes Costa; Barreto, Jaison Antônio; Lauris, José Roberto Pereira

doi:10.1590/abd1806-4841.20153385

Cited by 14 publications

(21 citation statements)

References 21 publications

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“…The later the diagnosis is performed, higher the risk of presenting deformities. An early diagnosis is the most effective way to avoid permanent damage, and the onset of deformity is more time-bound than the control actions of the disease (Porto et al, 2015;Monteiro et al, 2017b;Costa et al, 2019). Our results show that the leprosy diagnosis has been set earlier and the strategies of prevention and control of the disease are more effective than the past.…”

Section: Discussionmentioning

confidence: 99%

“…The transmission of leprosy occurs from intimate and prolonged contact of a susceptible individual with a bacilliferous patient through bacilli inhalation. The best way to stop transmission is early diagnosis and treatment (Porto et al, 2015;Anchieta et al, 2019). Leprosy manifests mainly through dermato-neurological signs and symptoms such as skin and peripheral nerves lesions, especially the medial, radial, ulnar, tibial, fibular and facial nerves (Duarte-Cunha et al, 2012).…”

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confidence: 99%

“…Only 20% of patients in Brazil are diagnosed at initial stages of the disease and about 70% of patients present some degree of disability when leprosy is diagnosed (Goulart, Goulart, 2008;Dias et al, 2018). The best way to prevent disabilities due to leprosy is an early diagnosis followed by treatment (Ferreira et al, 2012;Porto et al, 2015). Patients should undergo neurological assessments at the beginning, during and at the end of treatment.…”

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confidence: 99%

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Clinical and epidemiological profile of Central-Western region of Brazil leprosy patients

Silva

Arruda

Nascimento

et al. 2019

BJHR

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Leprosy is a chronic bacterial granulomatous disease that affects skin and peripheral nerves and shows slow progression. This study was to trace the epidemiological and clinical profile of leprosy among cases reported in the Information System for Notifiable Diseases in Anápolis, Goiás, Central-West region of Brazil. This is an epidemiological, descriptive and a cross-sectional study. Between January 2011 and December 2016, assistance was provided to 484 patients with leprosy. Among the patients, 59.5% male and the most prevalent age group was between 20-40 years old. Brown population in 47.3% of the cases and 51.7% of the patients completed elementary education. The majority of the cases were multibacillary and Virchowian clinical forms were prevalent, with zero degree of disability detected in 79.56% of the patients. There was no death due to leprosy during the study period. The epidemiological data indicates that a greater integration between the population and primary care must be encouraged, a crucial step for health education and strategies in order to combat the disease.

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confidence: 99%

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confidence: 99%

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Clinical and epidemiological profile of Central-Western region of Brazil leprosy patients

Silva

Arruda

Nascimento

et al. 2019

BJHR

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“… 16 , 17 Regarding leprosy, a descriptive study conducted in the state of São Paulo revealed that this disease predominates in men. 18 Lastly, considering the main differential diagnosis of neoplastic etiology, a case-control study performed in the South region of Brazil showed that BCC diagnosis prevails among women (n = 74, 58.2%). 19 However, other studies involving larger series around the world revealed higher prevalence of BCC in men.…”

Section: Discussionmentioning

confidence: 99%

Final diagnosis of 86 cases included in differential diagnosis of American tegumentary leishmaniasis in a Brazilian sample: a retrospective cross-sectional study

Tirelli

Vernal

Roselino

2017

An. Bras. Dermatol.

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BackgroundCutaneous leishmaniasis is distributed worldwide, including Brazil. Its several clinical forms need to be distinguished from other dermatoses. Clinical similarities and lack of a gold standard diagnostic tool make leishmaniasis-like lesions a challenging diagnosis.Objectives.To report the final diagnosis of patients primarily suspected of having American tegumentary leishmaniasis (ATL).Methods.A retrospective cross-sectional study was conducted on the basis of medical records of 437 patients with clinical suspicion of ATL, registered in electronic hospital system between 1980 and 2013. Demographic, clinical, and laboratory data were compiled.Results.Analysis of 86 cases (19.7%) registered as ATL in one of the hypothesis revealed a different final diagnosis; 55 (63.9%) and 31 cases (36.1%) had skin and mucosal lesions, respectively. In 58 cases (67.4%), the requested PCR did not identify Leishmania sp. In 28 cases (32.5%), biopsies established the diagnosis and confirmed tumors, mycobacteriosis, and subcutaneous or systemic mycosis. Overall, 27% of the cases had inflammatory etiology, mainly nasal nonspecific inflammatory processes; 27% had infectious etiology, especially paracoccidioidomycosis and leprosy; 20% had neoplastic etiology, mainly basal and squamous cell carcinoma; 15% had miscellaneous etiology, including neuropathic ulcer, traumatic ulcers, idiopathic ulcer; 11% missed the follow-up.Study limitationsSome cases had no final diagnosis due to loss of follow-up.Conclusion.ATL can be confused with several differential diagnoses, especially inflammatory and infectious granulomatous diseases as well as non-melanoma skin cancers. Clinicians working in tropical areas should be aware of the main differential diagnosis of leishmaniasis-like lesions.

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“…Disabilities can affect children occupationally which can affect them economically in their future. 6 Moreover the various risk factors associated with leprosy patients and their contacts are still not clearly known. Only through intensive research helps in examination of group-level and individual level factors.…”

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Nutritional status and morbidity profile of children with contact to leprosy in the rural community

Venkatakrishnan¹,

Thangaraju

Jeganathan³

et al. 2018

Preprint

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Introduction: Childhood leprosy reflects upon the disease transmission in the community. So, this study aimed to find out the children with contact to leprosy in their surroundings, prevalence of leprosy or subclinical infections in them and to assess their nutritional status. The study was conducted for 2 months and analysed 70 children in the rural community who were living with a household contact of leprosy.Methods: 70 children in the rural areas surrounding Chengalpattu living with leprosy contacts were selected for carrying out the study. Information regarding their demographic characteristics, socioeconomic factors, environmental conditions, feeding practices, food habits and any present health problems or in the recent past were collected. The children were then subjected to anthropometric measurements. The children were clinically evaluated by a dermatologist qualified in paediatric leprosy and children who were diagnosed as cases of leprosy were classified according to Ridley-Jopling classification. Slit skin smears for acid fast bacilli was done in all children with suspicious skin lesions.Results:Out of the 70 children taken into the study, 41 were boys and 29 were girls. 7-22% of boys and 3-6% of girls and overall,4-15% children are severely malnourished. 19 out of the 70 children had clinical pallor. Among the 70 leprosy contact children, 3 children were diagnosed to have leprosy (4.28%).Of the 3, 2 children had multibacillary leprosy while 1 had paucibacillary leprosy, according to the WHO classification and all 3 were classified as cases of Borederline Tuberculoid Leprosy according to Ridley-Jopling classification. All these 3 children had contact to leprosy for 10 or more years living with them. Conclusion:It can be concluded that malnutrition, the closeness and duration of contact to leprosy are significant risk factors for leprosy . Regular contact screening and early case detection are essential strategies to prevent further transmission in the endemic areas. Diagnostic methods for detection of subclinical infection in contacts needs further research.

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Evaluation of the social, clinical and laboratorial profile of patients diagnosed with leprosy in a reference center in São Paulo

Cited by 14 publications

References 21 publications

Clinical and epidemiological profile of Central-Western region of Brazil leprosy patients

Clinical and epidemiological profile of Central-Western region of Brazil leprosy patients

Final diagnosis of 86 cases included in differential diagnosis of American tegumentary leishmaniasis in a Brazilian sample: a retrospective cross-sectional study

Nutritional status and morbidity profile of children with contact to leprosy in the rural community

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