Evaluation of the soluble fibrin monomer complexes and other coagulation parameters in obstetric patients

Gilabert, J.; Estellés, Amparo; Fernández, Mónica; Villa, Piedad; Aznar, José A.

doi:10.1016/0049-3848(82)90007-x

Cited by 15 publications

(4 citation statements)

References 14 publications

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“…In 1970, it was noted that the syndrome of amniotic fluid embolism represented 10% of all maternal deaths and a study in Sweden from 1965 to 1974 demonstrated that the syndrome of amniotic fluid embolism accounted for 22% of all maternal deaths (19,20). Asner and co-workers have described amniotic fluid embolism to account for DIC in only one of six patients with clinically obvious DIC and in none of 35 obstetric patients with laboratory evidence of DIC (21). However, it has also been noted in a combined retrospective and prospective study of DIC taken from the records of Massachusetts General Hospital, consisting of 60 prospectively studied patients and 15 retrospectively studied patients, that not one of these patients developed DIC in association with amniotic fluid embolism (22).…”

Section: Amniotic Fluid Embolismmentioning

confidence: 99%

“…Amniotic fluid contains a highly potent total thromboplastin-like activity; this procoagulant activity increases with time of gestation (34,35). In addition, amniotic fluid contains a relatively strong antifibrinolytic activity and, as such, causes a nonspecific inhibition of fibrinolytic system; this activity of amniotic fluid also increases during gestation (21). The fibrinolytic inhibition activity may predispose a patient to DIC and diffuse thrombotic phenomenon by inhibiting or dampening the usual secondary fibrinolytic response seen in DIC patients (42,43).…”

Section: Amniotic Fluid Embolismmentioning

confidence: 99%

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Disseminated Intravascular Coagulation: A Review of Etiology, Pathophysiology, Diagnosis, and Management: Guidelines for Care

Bick

2002

Clin Appl Thromb Hemost

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The pathophysiologic mechanisms, clinical, and laboratory manifestations of DIC are complex in part due to interrelationships within the hemostasis system. Only by clearly understanding these extraordinarily complex pathophysiologic interrelationships can the clinician and laboratory scientist appreciate the divergent and wide spectrum of often confusing clinical and laboratory findings in patients with DIC. Many therapeutic decisions to be made are controversial and lack validation. Nevertheless, newer antithrombotic agents, and agents that can block, blunt, or modify cytokine activity and the activity of vasoactive substances appear to be of value. The complexity and variable degree of clinical expression suggests that therapy should be individualized depending on the nature of DIC, age, etiology of DIC, site and severity of hemorrhage or thrombosis and hemodynamics and other appropriate clinical parameters. At present, treatment of the triggering event, low-dose heparin or antithrombin concentrate and wise choice of components when indicated appear to be the most effective modes of therapy.

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Section: Amniotic Fluid Embolismmentioning

confidence: 99%

Section: Amniotic Fluid Embolismmentioning

confidence: 99%

Disseminated Intravascular Coagulation: A Review of Etiology, Pathophysiology, Diagnosis, and Management: Guidelines for Care

Bick

2002

Clin Appl Thromb Hemost

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“…The second of these bands is composed of crosslinked fibrin material [18]. This band appears with greater frequency and in greater propor tion in those obstetric cases in which DIC may exist, and it persists when the clinical evolution of the patient is not favorable [19].…”

Section: Discussionmentioning

confidence: 99%

Soluble Fibrin Monomer Complexes and Other Hemostatic Parameters in Patients with Intrauterine Fetal Death

Gilabert¹,

Estellés²,

Aznar³

et al. 1985

Gynecol Obstet Invest

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Hemostatic parameters, especially soluble fibrin monomer complexes, have been studied in 114 patients with intrauterine fetal death. The patients were classified into three groups according to the duration of fetal retention. A correlation was observed between a longer duration of fetal retention and the hemostatic alteration. Moreover, in the groups of patients in which this hemostatic disorder was more evident, an improvement in these alterations was detected after fetal evacuation. A hemorrhagic picture with consumption of coagulation factors and cross-linked fibrin oligomers was detected after uterine evacuation in only 1 case and required an emergency hysterectomy and the administration of blood and plasma. In the rest of the patients, fetal evacuation was sufficient to normalize the parameters and no hemorrhagic complications were observed. The favorable evolution and minimal hemostatic alterations in the majority of the patients with intrauterine fetal death, when early obstetric management was established, are discussed.

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“…11--13 Several investigators have used these methods to examine the relevance of FMC in thrombotic patients, including pregnant women. One study showed that soluble FMC increases gradually during the course of pregnancy, 12 while another study demonstrated that FMC is elevated in disseminated intravascular coagulation during pregnancy. 13 However, FMC testing has not yet been widely used for the detection of coagulation status, possibly due to its nonquantitative features and a complicated measurement procedure.…”

mentioning

confidence: 99%

Fibrin monomer complex in normal pregnant women: a potential thrombotic marker in pregnancy

Onishi¹,

Kaniyu²,

Iwashita

et al. 2007

Ann Clin Biochem

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Evaluation of the soluble fibrin monomer complexes and other coagulation parameters in obstetric patients

Cited by 15 publications

References 14 publications

Disseminated Intravascular Coagulation: A Review of Etiology, Pathophysiology, Diagnosis, and Management: Guidelines for Care

Disseminated Intravascular Coagulation: A Review of Etiology, Pathophysiology, Diagnosis, and Management: Guidelines for Care

Soluble Fibrin Monomer Complexes and Other Hemostatic Parameters in Patients with Intrauterine Fetal Death

Fibrin monomer complex in normal pregnant women: a potential thrombotic marker in pregnancy

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