The interactions between the indicators of sustainable regional development due to the exploitation of raw material deposits in the Slovak Republic are the starting point for effective raw material management. The primary objective of the study is to point out the interactions of explicitly defined indicators of raw material deposits exploitation, which have an overall impact on sustainable development in the Slovak Republic. Based on the development tendencies of selected social, economic, and environmental indicators, the article defines individual indicators that create the potential for further sustainable development. For an effective evaluation of all the indicators, the analytic hierarchy process was used for the identification of the priorities of the indicators. Based on all the relevant factors and previous experience, and results of the conducted analysis, 14 positive and 14 negative indicators were identified. Based on the complex evaluation of raw material in the process of sustainable development in the Slovak Republic, negative factors were prevailing over the positive ones by a scoring rate of 0.90, and the total impact was identified as average profitability of sustainable development support. Accepting all the principles of sustainable development, a model of effective evaluation of raw material deposits and management of raw material exploitation in regional sustainable development of the Slovak Republic based on the quantification of their interactions was developed.