Evaluation of the therapeutic effect of radiotherapy on cervical cancer using magnetic resonance imaging

Hatano, Kazuo; Sekiya, Yuji; Araki, Hitoshi; Sakai, Mitsuhiro; Togawa, Takashi; Narita, Yuichiro; Akiyama, Yoshihisa; Kimura, Shota; Ito, Hisao

doi:10.1016/s0360-3016(99)00228-x

Cited by 97 publications

(79 citation statements)

References 23 publications

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“…To our knowl- edge, only 2 reports concern this issue. Hatano and colleagues 15 and Mayr's group 16 deˆned central recurrence as local recurrence, and our result was consistent with theirs. In a study of 42 patients, Hatano's team 15 correlated serial MR imagingbased tumor volume with local control rate and indicated that MR imaging studies performed at 30 Gy of external irradiation and MR imaging studies performed 3 months after RT were predictive indices of local control.…”

Section: Discussionsupporting

confidence: 91%

“…On T 2 -weighted images, tumor usually shows higher signal intensity than that of the normal cervix. 5,[13][14][15] RT is a major treatment option for patients with cervical cancer, and response to RT aŠects individual outcomes. If relevant predictive factors can be established for ultimate therapy outcome and be detected early during the course of RT, timely and individualized adaptations of the treatment regimen will be possible, including RT dose intensiˆcation, changes in the concurrent therapy regimen, or addition of novel clinical trial therapies.…”

Section: Discussionmentioning

confidence: 99%

“…13 Several reports that determine valuable prognostic factors early during RT have also been published. 1,5,[13][14][15][16][17][18][19][20][21][22][23][24][25][26] Some suggest that several tumor regression rates during RT are useful to predict outcome, 1,15-17 but most include pelvic wall recurrence and peripheral recurrence in the local recurrence category. Therefore, we attempted to evaluate the relationship between the true local recurrence rate and the tumor volume or reduction rate just before completion of RT or just after.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Can MRI Predict Local Control Rate of Uterine Cervical Cancer Immediately after Radiation Therapy?

Tanaka¹,

Ohara²,

Oki³

et al. 2010

magn reson med sci

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Purpose: To evaluate the utility of measuring the volumes of areas of high signal intensity on T 2 -weighted magnetic resonance (MR) images immediately after irradiation for predicting the local control rate of uterine cervical cancer.Materials and Methods: From our departmental database, we identiˆed 109 patients with cervical cancer who underwent MR imaging before irradiation and just before or just after completion of radiation therapy from 1994 to 2007. We included 46 of the 109 patients in this study, 5 patients with local recurrence and 41 patients who were free of disease for more than 2 years. Fifteen received radiation therapy alone, and 28 patients received concurrent chemoradiation therapy. We measured the volumes of areas of high signal intensity involving the uterine cervix on T 2 -weighted MR images before radiation therapy and just before or just after its completion. We measured the 3 orthogonal diameters to calculate the volume as an ellipsoid and evaluated proportional tumor volume and the rate of reduction. We analyzed statistics with Student's t-test.Results: In patients with local recurrence, the mean volume of the areas of high signal intensity on T 2 -weighted MR images just before completion of irradiation therapy or just after was 19.70 cm 3 , which was signiˆcantly larger than that in patients without recurrence (1.77 cm 3 , Pº0.05). The proportional tumor volume was also signiˆcantly larger (Pº 0.05).Conclusions: Although areas of high signal intensity on T 2 -weighted MR images include acute radiation change, their volume and the proportional tumor volume after irradiation can be useful clues in predicting the local control rate of uterine cervical cancer.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Can MRI Predict Local Control Rate of Uterine Cervical Cancer Immediately after Radiation Therapy?

Tanaka¹,

Ohara²,

Oki³

et al. 2010

magn reson med sci

View full text Add to dashboard Cite

show abstract

“…Simple diameter-based tumor measurement appears to be equivalent to contour tracing/ROI analysis 3D tumor volumetry for tumor size assessment for predicting outcome. 25,26 Diameter-based measurement can be easily computed as an ellipsoid-shaped tumor volume, but does not consider irregularities in tumor border and shape, which can be accounted for by 3D ROI volumetry. Thus it may be less accurate because cervical cancers have irregular contour that deviate from the idealized ellipsoid volume.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of tumor volume and lymph node involvement assessed by MRI in stage IIB cervical cancer patients treated with concurrent chemoradiation therapy

Lee

Kim

et al. 2010

J Gynecol Oncol

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Objective: The purpose of this study was to evaluate the prognostic significance of tumor volume assessed by pretreatment MRI in stage IIB cervical cancer patients with concurrent chemoradiation therapy. Methods: A retrospective chart review was performed on seventy five patients with cervical cancer who were treated with concurrent weekly cisplatin (40 mg/m 2 ) and radiotherapy between January 2000 and April 2007. Potential prognostic factors were age, chemotherapy numbers, histology, tumor diameter and volume, lymph node (LN) involvement and pretreatment squamous cell carcinoma antigen (SCC-Ag) levels. Results: The median follow-up time was 55 months (range, 8 to 104 months). The median tumor size and volume (range) were 4.5 cm (2 to 10) and 33.1 mL (4.2 to 392.7), respectively. Pelvic LN enlargement rate was 58.7%. Para-aortic LN enlargement rate was 14.7%. Using multivariate analysis, a tumor volume (＞33 mL, p=0.025), pelvic LN enlargement (p=0.044) revealed a significantly unfavorable outcome on overall survival. PFS was influenced by tumor histology (p＜0.001), pelvic LN enlargement (p=0.015) and pretreatment SCC-Ag levels (p=0.018). We found that 22 (29.3%) patients had recurrences and 14 (18.7%) patients died of disease. The 5-year overall survival rate was 80.6% (standard error, 4.9%) and 5-year PFS rate was 71.3% (standard error, 5.3%). Conclusion: Tumor volume and pelvic LN involvement showed possibility to predict overall survival in patient with stage ⅡB cervical cancer. Optimal tumor volume and pelvic LN assessment by pretreatment MRI might be helpful to predict treatment outcome.

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“…Clinical palpation is also a subjective method and has significant interobserver variability [26][27][28]. More recent studies have shown that the three-dimensional quantitative imaging-based method of tumor size measurement using MRI is highly accurate in determining actual tumor size and extent to surrounding tissue [2,3,15,16,[29][30][31][32][33][34][35][36][37]. MRI has been recognized as an important imaging modality for the management of cervical cancer because of its multiplanar capability and distinct tissue contrast, particularly between tumor and surrounding normal tissue [9].…”

Section: Discussionmentioning

confidence: 99%

Method of Tumor Volume Evaluation using Magnetic Resonance Imaging for Outcome Prediction in Cervical Cancer Treated with Concurrent Chemotherapy and Radiotherapy

Kim

2008

International Journal of Radiation Oncology*Biology*Physics

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Evaluation of the therapeutic effect of radiotherapy on cervical cancer using magnetic resonance imaging

Cited by 97 publications

References 23 publications

Can MRI Predict Local Control Rate of Uterine Cervical Cancer Immediately after Radiation Therapy?

Can MRI Predict Local Control Rate of Uterine Cervical Cancer Immediately after Radiation Therapy?

Clinical significance of tumor volume and lymph node involvement assessed by MRI in stage IIB cervical cancer patients treated with concurrent chemoradiation therapy

Method of Tumor Volume Evaluation using Magnetic Resonance Imaging for Outcome Prediction in Cervical Cancer Treated with Concurrent Chemotherapy and Radiotherapy

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