Evaluation of the TierPET system

Weber, Simone; Herzog, Hans; Coenen, Heinz H.; Cremer, Markus; Engels, R.; Hamacher, Kurt; Kehren, F.; Muehlensiepen, H.; Ploux, Lydie; Reinartz, R.; Reinhart, P.; Rongen, F.; Sonnenberg, Frank A.; Halling, H.

doi:10.1109/23.790853

Cited by 55 publications

(15 citation statements)

References 22 publications

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“…This makes the input signal distribution energy independent and simplifies the problem. In addition re-scaling the input data between [ 1,1] or [0, 1] improves the learning speed of the neural network [15].…”

Section: ) Data Preparationmentioning

confidence: 99%

“…Due to the small nature of the organs in these animals, several groups have been developing prototype detector modules with very small scintillation crystals to get the best possible spatial resolution [1]- [7]. To sustain these very high resolutions in dynamic PET studies, it is mandatory to collect a sufficient number of events per image frame to minimize the S/N in the reconstructed PET image.…”

Section: Introductionmentioning

confidence: 99%

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Study of spatial resolution and depth of interaction of APD-based PET detector modules using light sharing schemes

Bruyndonckx

Léonard

Liu

et al. 2003

IEEE Trans. Nucl. Sci.

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Using 4 8 Hamamatsu S8550 APD matrices with 1.6 mM 1.6 mm pixels and a 2.3 mm pitch, we compared the spatial resolution of light sharing schemes using block detectors to detector modules using 1-to-1 coupling between individual 2 mm 2 mm 10 mm LSO crystals and APD pixels. In addition, depth of interaction (DOI) measurement capabilities of the block detector were studied.Using neural network methods to determine the interaction position in a 10 mm thick LSO block, we achieved an intrinsic spatial resolution of 1.5 mm FWHM compared to 2.06 mm for individual readout. The DOI resolution varied between 1.8 and 3.0 mm FWHM.Index Terms-Block detectors, neural network, positron emission tomography (PET).

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Section: ) Data Preparationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study of spatial resolution and depth of interaction of APD-based PET detector modules using light sharing schemes

Bruyndonckx

Léonard

Liu

et al. 2003

IEEE Trans. Nucl. Sci.

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“…In the ensuing years several designs of small animal PET systems were realized. Various implementations have been reported in the literature using a variety of detector and design technologies [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Design considerations and construction of a small animal PET prototype

Tzanakos

Nikolaou

Drakoulakos

et al. 2006

Nuclear Instruments and Methods in Physics Research Section A:

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“…Because the combined influence of other effects (photon noncolinearity and positron range) for the most common used isotopes is small, the dominant factor limiting the spatial resolution has been the construction of high-resolution detectors in continuous geometries (18,19). Several research groups have developed high-resolution detectors (20)(21)(22), which enabled the development of high-resolution tomographic systems (6,(23)(24)(25). Although these early systems were developed as prototypes for in-house research in large research centers, their success and the newly developed need for marketed systems has led to the development of several commercial versions from manufacturers (26)(27)(28).…”

Section: Principles Of Pet and Spectmentioning

confidence: 99%

Instrumentation for Molecular Imaging in Preclinical Research: Micro-PET and Micro-SPECT

Chatziioannou¹

2005

Proceedings of the American Thoracic Society

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Noninvasive imaging of molecular events and interactions in living small animal models has gained increasing importance in preclinical research. Two of the imaging modalities available for this research with potential for translation to the clinic are dedicated small animal positron emission tomography and single-photon emission computed tomography. This brief review introduces the fundamental principles behind these imaging technologies and instrumentation, and discusses the limitations in terms of their spatial resolution and sensitivity. In addition, it provides a perspective regarding the research and commercial development of these systems and presents examples of biological applications. Finally, it discusses the major challenges facing these technologies, advantages and limitations with respect to other technologies, and some future prospects.Keywords: Small animal imaging; positron emission tomography; single-photon emission computed tomography; preclinical imaging Animal models have been an integral part of biomedical research in the study of disease and physiologic processes (1). Tracer methods that rely on the introduction of a usually radioactively labeled molecule in very small concentrations were traditionally used, in combination with organ dissection and tissue counting (2). Alternatively, whole-body cryosection followed by digital autoradiography (3) can also provide anatomic images with exquisite spatial resolution ‫ف(‬ 50 m) correlated with quantitative measures of the tracer concentration. The drawback of these ex vivo methodologies is that only a single time point per animal can be sampled during an investigation. The lack of a method to study repeatedly the same animal model before, during, and after an intervention has been a significant limitation of these traditional investigative methods. Noninvasive positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging instrumentation that was originally developed for clinical applications had until recently inadequate spatial resolution for imaging small animals. Mice, the preferred mammalian models for genetic manipulation and biological research (4), are on the order of 2,500 times smaller than a human adult. A concomitant improvement in spatial resolution is required to achieve similar types of studies and results. That is a very large distance to be covered and the first attempts to bridge it were in the 1990s when the first dedicated imaging

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Evaluation of the TierPET system

Cited by 55 publications

References 22 publications

Study of spatial resolution and depth of interaction of APD-based PET detector modules using light sharing schemes

Study of spatial resolution and depth of interaction of APD-based PET detector modules using light sharing schemes

Design considerations and construction of a small animal PET prototype

Instrumentation for Molecular Imaging in Preclinical Research: Micro-PET and Micro-SPECT

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