Evaluation of the toxicity of 1-butyl-3-methyl imidazolium tetrafluoroborate using earthworms (Eisenia fetida) in two soils

Shao, Yuting; Hou, Kaixuan; Du, Zhongkun; Li, Bing; Wang, Jun; Juhasz, Albert L.; Wang, Jinhua; Zhu, Lusheng

doi:10.1016/j.scitotenv.2019.06.010

Cited by 35 publications

(6 citation statements)

References 43 publications

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“…This processing step is particularly essential for electrospun materials that are designed to interface with biological systems, as many pyrrolidinium and imidazolium ILs exhibit significant cellular toxicity toward eukaryotic cells. [39][40][41][42] In contrast to these approaches, our interest was to include CAGE as an auxiliary component into the HFIP/bGE solution with the intent that the material would remain in the scaffold after deposition. 26 This approach enabled the IL to act as an electrospinning adjuvant in the deposition process in concurrence with impregnation of the antibacterial material…”

Section: Discussionmentioning

confidence: 99%

“…In these cases, however, the ILs were used as neat solvents to dissolve the respective biopolymer, and excess IL was removed from the solid material in a post‐deposition extraction step. This processing step is particularly essential for electrospun materials that are designed to interface with biological systems, as many pyrrolidinium and imidazolium ILs exhibit significant cellular toxicity toward eukaryotic cells 39‐42 . In contrast to these approaches, our interest was to include CAGE as an auxiliary component into the HFIP/bGE solution with the intent that the material would remain in the scaffold after deposition 26 .…”

Section: Discussionmentioning

confidence: 99%

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Integration of choline geranate into electrospun protein scaffolds affords antimicrobial activity to biomaterials used for cutaneous wound healing

et al. 2020

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Wound healing attempts to maintain homeostasis in the wound while minimizing the risk of infection to the tissue by foreign agents, such as opportunistic bacterial pathogens. Biofilms established by these pathogens are a common cause of chronic infections that slow the healing process. Preparation of skin wound healing devices comprised of electrospun proteins associated with skin have been shown to accelerate the healing process relative to conventional wound dressings. In this work, we have developed electrospinning methods to incorporate the antimicrobial ionic liquid/deep eutectic solvent choline geranate (CAGE) into these devices. Integration of CAGE into the dressing material was verified via 1 H nuclear magnetic resonance spectrometry, and the effect on the material property of the resultant devices were assessed using scanning electron microscopy. CAGE-containing devices demonstrate a concentration-dependent inactivation of exogenously applied solutions of both gram-positive and gram-negative pathogens (Enterococcus sp and Pseudomonas aeruginosa, respectively), but maintain their ability to serve as a compatible platform for proliferation of human dermal neonatal fibroblasts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Integration of choline geranate into electrospun protein scaffolds affords antimicrobial activity to biomaterials used for cutaneous wound healing

et al. 2020

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“…462−464 Of note, in a study on C 4 MIm BF 4 , the IL demonstrated higher toxicity in natural (fluvo-aquic) soil than in artificial soil. 464 Larvae of the silkworm B. mori were also used as test models for assessing the environmental toxicity of ILs. C 8 MIm Cl, C 8 MIm BF 4 , and C 8 M(3)Py Cl were shown to trigger oxidative stress in the midguts and silk glands of larvae.…”

Section: Paramisgurnus Dabryanusmentioning

confidence: 99%

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Egorova,

Kibardin,

Posvyatenko

et al. 2024

Chem. Rev.

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The review presents a detailed discussion of the evolving field studying interactions between ionic liquids (ILs) and biological systems. Originating from molten salt electrolytes to present multiapplication substances, ILs have found usage across various fields due to their exceptional physicochemical properties, including excellent tunability. However, their interactions with biological systems and potential influence on living organisms remain largely unexplored. This review examines the cytotoxic effects of ILs on cell cultures, biomolecules, and vertebrate and invertebrate organisms. Our understanding of IL toxicity, while growing in recent years, is yet nascent. The established findings include correlations between harmful effects of ILs and their ability to disturb cellular membranes, their potential to trigger oxidative stress in cells, and their ability to cause cell death via apoptosis. Future research directions proposed in the review include studying the distribution of various ILs within cellular compartments and organelles, investigating metabolic transformations of ILs in cells and organisms, detailed analysis of IL effects on proteins involved in oxidative stress and apoptosis, correlation studies between IL doses, exposure times and resulting adverse effects, and examination of effects of subtoxic concentrations of ILs on various biological objects. This review aims to serve as a critical analysis of the current body of knowledge on IL-related toxicity mechanisms. Furthermore, it can guide researchers toward the design of less toxic ILs and the informed use of ILs in drug development and medicine.

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“…The OTM values increased with increasing IL concentration and exposure time, indicating that the degree of DNA damage also increased, especially for concentrations higher than 5 mg·kg −1 . The ecotoxicity of [C 8 mim][BF 4 ] to earthworms was also studied in two types of soil: fluvo-aquic soil and artificial soil [ 145 ]. The acute toxicity of this IL was higher in fluvo-aquic soil (7d LC 50 = 744 mg kg −1 and 14d LC 50 = 489 mg·kg −1 ) than in the artificial soil (7d LC 50 = 870 mg·kg −1 and 14d LC 50 = 679 mg·kg −1 ).…”

Section: Effect Of Ionic Liquids On Animalsmentioning

confidence: 99%

Ionic Liquids—A Review of Their Toxicity to Living Organisms

Gonçalves

Paredes

Cristino

et al. 2021

IJMS

128

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Ionic liquids (ILs) were initially hailed as a green alternative to traditional solvents because of their almost non-existent vapor pressure as ecological replacement of most common volatile solvents in industrial processes for their damaging effects on the environment. It is common knowledge that they are not as green as desired, and more thought must be put into the biological consequences of their industrial use. Still, compared to the amount of research studying their physicochemical properties and potential applications in different areas, there is a scarcity of scientific papers regarding how these substances interact with different organisms. The intent of this review was to compile the information published in this area since 2015 to allow the reader to better understand how, for example, bacteria, plants, fish, etc., react to the presence of this family of liquids. In general, lipophilicity is one of the main drivers of toxicity and thus the type of cation. The anion tends to play a minor (but not negligible) role, but more research is needed since, owing to the very nature of ILs, except for the most common ones (imidazolium and ammonium-based), many of them are subject to only one or two articles.

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Evaluation of the toxicity of 1-butyl-3-methyl imidazolium tetrafluoroborate using earthworms (Eisenia fetida) in two soils

Cited by 35 publications

References 43 publications

Integration of choline geranate into electrospun protein scaffolds affords antimicrobial activity to biomaterials used for cutaneous wound healing

Integration of choline geranate into electrospun protein scaffolds affords antimicrobial activity to biomaterials used for cutaneous wound healing

Mechanisms of Biological Effects of Ionic Liquids: From Single Cells to Multicellular Organisms

Ionic Liquids—A Review of Their Toxicity to Living Organisms

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