Evaluation of the treatment of port-wine stains with the 595-nm long pulsed dye laser: A large prospective study in adult Japanese patients

Asahina, Akihiko; Watanabe, Takahiro; Kishi, Akiko; Hattori, Naoko; Shirai, Akira; Kagami, Shinji; Watanabe, Rei; Pavoux, Andre Le; Maekawa, Takeo; Tamaki, Kunihiko; Ohara, Kuniaki

doi:10.1016/j.jaad.2005.11.1034

Cited by 51 publications

(26 citation statements)

References 38 publications

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“…2 The pulsed dye laser (PDL, 585 nm) has for many years been the treatment of choice for PWS and several studies have documented the efficacy and safety of PDL including the newer generation long-pulsed dye laser (LPDL, 595 nm). [3][4][5][6][7][8][9][10] Most patients achieve satisfactory results with a significant reduction in the degree of reddening of the birthmark. Approximately 20% of patients are, however, poor responders and do not achieve adequate treatment results.…”

Section: Discussionmentioning

confidence: 99%

Pulsed dye laser vs. intense pulsed light for port-wine stains: a randomized side-by-side trial with blinded response evaluation

Faurschou

Togsverd‐Bo

Zachariae

et al. 2009

British Journal of Dermatology

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Background Pulsed dye lasers (PDLs) are considered the treatment of choice for port-wine stains (PWS). Studies have suggested broadband intense pulsed light (IPL) to be efficient as well. So far, no studies have directly compared the PDL with IPL in a randomized clinical trial. Objectives To compare efficacy and adverse events of PDL and IPL in an intraindividual randomized clinical trial. Methods Twenty patients with PWS (face, trunk, extremities; pink, red and purple colours; skin types I-III) received one side-by-side treatment with PDL (V-beam Perfecta, 595 nm, 0AE45-1AE5 ms; Candela Laser Corporation, Wayland, MA, U.S.A.) and IPL (StarLux, Lux G prototype handpiece, 500-670 and 870-1400 nm, 5-10 ms; Palomar Medical Technologies, Burlington, MA, U.S.A.). Settings depended on the preoperative lesional colour. Treatment outcome was evaluated by blinded, clinical evaluations and by skin reflectance measurements. Results Both PDL and IPL lightened PWS. Median clinical improvements were significantly better for PDL (65%) than IPL (30%) (P = 0AE0004). A higher proportion of patients obtained good or excellent clearance rates with the PDL (75%) compared with IPL (30%) (P = 0AE0104). Skin reflectance also documented better results after PDL (33% lightening) than IPL (12% lightening) (P = 0AE002). Eighteen of 20 patients preferred to receive continued treatments with PDL (P = 0AE0004). No adverse events were observed with PDL or IPL. Conclusions Both the specific PDL and IPL types of equipment used in this study lightened PWS and both were safe with no adverse events. However, the PDL conveyed the advantages of better efficacy and higher patient preference.

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Section: Discussionmentioning

confidence: 99%

Pulsed dye laser vs. intense pulsed light for port-wine stains: a randomized side-by-side trial with blinded response evaluation

Faurschou

Togsverd‐Bo

Zachariae

et al. 2009

British Journal of Dermatology

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“…However, in extreme environment, skin fails to protect the body when the temperature lies outside the normal physiological range. Furthermore, in medicine, with advances in laser, microwave and similar technologies, various thermal therapeutic methods have been used to cure skin disease/injury, such as the removal of port-wine stains [1][2][3], pigmented and cutaneous lesions [4][5][6] and tattoos [7]. The objective is to induce thermal injury precisely within tissue structures located up to several millimeters below the surface but without affecting the surrounding, healthy tissue.…”

Section: Introductionmentioning

confidence: 99%

Biothermomechanical behavior of skin tissue

Seffen

2008

Acta Mech. Sin.

133

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Advances in laser, microwave and similar technologies have led to recent developments of thermal treatments involving skin tissue. The effectiveness of these treatments is governed by the coupled thermal, mechanical, biological and neural responses of the affected tissue: a favorable interaction results in a procedure with relatively little pain and no lasting side effects. Currently, even though each behavioral facet is to a certain extent established and understood, none exists to date in the interdisciplinary area. A highly interdisciplinary approach is required for studying the biothermomechanical behavior of skin, involving bioheat transfer, biomechanics and physiology. A comprehensive literature review pertinent to the subject is presented in this paper, covering four subject areas: (a) skin structure, (b) skin bioheat transfer and thermal damage, (c) skin biomechanics, and (d) skin biothermomechanics. The major problems, issues, and topics for further studies are also outlined. This review finds that significant advances in each of these aspects have been achieved in recent years. Although focus is placed upon the biothermomechanical behavior of skin tissue, the fundamental concepts and methodologies reviewed in this paper may also be applicable for studying other soft tissues.

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“…Advances in laser, microwave, and similar technologies have led to recent developments of thermal treatments for different diseases and injuries involving skin tissue, such as the removal of port-wine stains (Asahina et al, 2006;Kono et al, 2006;Shafirstein et al, 2003), pigmented and cutaneous (Zamanian and Hardiman, 2005).…”

Section: Introductionmentioning

confidence: 99%

Skin biothermomechanics for medical treatments

Wen

et al. 2008

Journal of the Mechanical Behavior of Biomedical Materials

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Evaluation of the treatment of port-wine stains with the 595-nm long pulsed dye laser: A large prospective study in adult Japanese patients

Cited by 51 publications

References 38 publications

Pulsed dye laser vs. intense pulsed light for port-wine stains: a randomized side-by-side trial with blinded response evaluation

Pulsed dye laser vs. intense pulsed light for port-wine stains: a randomized side-by-side trial with blinded response evaluation

Biothermomechanical behavior of skin tissue

Skin biothermomechanics for medical treatments

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