Evaluation of the usage of incisional liposomal bupivacaine as a local anaesthetic for dogs undergoing limb amputation

Villatoro, Ashley S; Phelps, Holly A; Ganjei, Justin B

doi:10.1002/vms3.1159

Cited by 2 publications

(4 citation statements)

References 45 publications

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“…Complications included bruising, dehiscence, discharge, dermatitis, and surgery site infection. In contrast, one study found only 13% of incisional complications in the BLIS group compared to 34% in those that received a nonliposomal formulation, and another study found no increased risk in infection for abdominal incisions 24,25 . In this study, there were no incisional infections.…”

Section: Discussioncontrasting

confidence: 76%

“…In contrast, one study found only 13% of incisional complications in the BLIS group compared to 34% in those that received a nonliposomal formulation, and another study found no increased risk in infection for abdominal incisions. 24,25 In this study, there were no incisional infections. The dogs were evaluated subjectively but no specific scoring systems were used to evaluate bruising or swelling.…”

Section: Discussionmentioning

confidence: 53%

“…A recent retrospective study found decreased incisional complications in BLIS versus control dogs after amputation 25 . However, there have been no clinical prospective studies reporting the efficacy of BLIS in dogs undergoing limb amputation.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20][21][22][23][24] A recent retrospective study found decreased incisional complications in BLIS versus control dogs after amputation. 25 However, there have been no clinical prospective studies reporting the efficacy of BLIS in dogs undergoing limb amputation. The objective of this study was to determine the clinical efficacy and adverse effects of BLIS as compared to a constant rate infusion (CRI) of fentanyl for the provision of postsurgical analgesia in dogs undergoing limb amputation.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of bupivacaine liposome injectable solution and fentanyl for postoperative analgesia in dogs undergoing limb amputation

Paul,

Strelchik,

O'Day

et al. 2024

Veterinary Surgery

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ObjectiveThe objectives of the study were to compare the clinical efficacy and adverse effects of two analgesic protocols consisting of bupivacaine liposome injectable solution (BLIS) and 0.5% bupivacaine and fentanyl for postsurgical analgesia in dogs undergoing limb amputation.Study designRandomized, double‐blind, prospective, controlled, intent‐to‐treat, clinical noninferiority trial.AnimalsForty client‐owned dogs.MethodsDogs undergoing amputation were randomly assigned to either the BLIS or control group. Postoperative pain, sedation, nausea, and amount eaten were assessed using appropriate scales at 6, 12, 18, and 24 h by trained individuals blinded to the treatment protocol. Rescue analgesia was provided for Glasgow composite measure pain scale (short form) (CMPS‐SF) scores of 5 or above. Clients were requested to pain score their dogs at home using a visual analogue scale (VAS) for 48 h following discharge.ResultsForty dogs completed this study (20 control dogs and 20 BLIS dogs). The BLIS and control groups were equivalent for sedation, nausea, amount eaten, and pain, at all time periods except at 6 h (p < .01), when the BLIS group pain score was lower.ConclusionThe BLIS provided equivalent analgesia with fewer adverse effects than fentanyl constant rate infusion (CRI) following limb amputation. Rescue analgesia was provided to five dogs in the BLIS group and four in the control group, and there was no statistical difference. Nausea scores did not differ statistically.Clinical significanceAs BLIS provides equivalent analgesia, this may allow for decreased reliance on opioids in the immediate postoperative period.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%