Evaluation of the variations and potential clinical use of second trimester serum markers for the detection of pre-eclampsia

Gautam, Savita S.; Kaur, Manmeet; Chaudhary, Naimaa K.; Sharma, Asha

doi:10.18203/2320-1770.ijrcog20182904

Cited by 2 publications

(2 citation statements)

References 14 publications

(16 reference statements)

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“…Thisfurther supports our finding that beta HCG has a valuable role in predicting PIH. PIH seldom develops after the second trimester, and the pathogenesis starts early in pregnancy 16 , as shown by stratification of gestational age and beta HCG levels in pregnant patients between 13-18 weeks of gestation (p-value <0.001; significant). Similar results have been shown by Feng et al, who displayed the positive correlation between absolute levels of serum beta-HCG and the severity of pregnancy induced hypertension (p-value ≤0.05) 17 .…”

Section: Discussionmentioning

confidence: 98%

Association of Human Chorionic Gonadotrophin With Pregnancy Induced Hypertension

Chatha

Jaffery

Qamar

et al. 2020

PAFMJ

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Objective: To determine the positive predictive value of beta Human Chorionic Gonadotrophin in early secondtrimester for predicting pregnancy induced hypertension. Study Design: Cross-sectional study. Place and Duration of Study: Department of Obstetrics and Gynaecology Combined Military Hospital, Lahore,from Jun 2017 to Nov 2017. Methodology: A total of 214 female pregnant patients met the criteria for inclusion in this study. Patients withbeta human chorionic gonadotrophin (βHcg) levels ≥2 MoM were followed at 22, 26, 30 and 34 weeks of gestation. Blood pressure was monitored. Pregnancy induced hypertension (PIH) was labelled after 20 weeks (as per dating scan) of gestation in patients who did not have proteinuria (≥300 mg 24 hour urine sample) and had a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg (blood pressure readings taken at two separate points in time four hours apart). Results: Patients ranged between 18-35 years of age, with the mean age being 27.3 ± 4.3 years. Mean gestational age was observed to be 15.6 ± 1.8 weeks. Mean BMI was 23.8 ± 3.2 kg/m2. Out of 214 patients, 30 patients (14%) had beta human chorionic gonadotrophin level >2 MoM. Out of these 30 patients, 25 patients (83.3%) developed PIH. There were 100 primigravida (46.7%) and 114 multigravidas (53.3%). Beta human chorionic gonadotrophin in predicting pregnancy induced hypertension showed sensi-tivity of 96.1%, a specificity of 97.3%, with a PPV83.3%, a NPV 99.4% and diagnostic accuracy of 97.2%.

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Section: Discussionmentioning

confidence: 98%

Association of Human Chorionic Gonadotrophin With Pregnancy Induced Hypertension

Chatha

Jaffery

Qamar

et al. 2020

PAFMJ

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“…These observations were concordant with contemporary research. [6,15,16] Fifty five per cent of the hypertensive women were delivered by lower segment caesarean section and among them 81.8% belonged to the severe hypertensive category. Only 28.2% normotensive women underwent lower segment caesarean section and this observation was statistically significant (p<0.001).…”

Section: Discussion:-mentioning

confidence: 99%

Correlation Between the Early Mid-Trimester (13-20 Weeks) Maternal Serum Beta-HCG Levels and the Developmentof Gestational Hypertension Later in the Pregnancy, a Prospective Observational Study.

Pandit¹,

Wani²,

Ahmad³

et al. 2018

IJAR

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Background: Gestational hypertension is a common but potentially life threatening complication of pregnancy. Till date no accurate diagnostic modalities are available for its early prediction so that adequate timely measures could be taken for prevention, early detection and adequate management. Objective: To evaluate the role of mid-trimester maternal serum βhCG levels for the prediction of development of pre-eclampsia and its severity later in the pregnancy. Methods: The study was a prospective observational study involving a total of 178 randomly selected women, between 13 to 20 weeks of gestation. Early mid-trimester βhCG levels were estimated and absolute values converted to population based multiples of median (MOM) and development and severity of hypertension/pre-eclampsia was observed in the follow up. Results: Out of a total of 178 only 165 women could be followed till end. Among 142 women with mid-trimester βhCG levels< 2 MOM only 2 developed hypertension. Twenty three women had βhCG values >2 MOM and in this group 47.8% women developed severe hypertension (p<0.001). A positive correlation between the severity of hypertension and absolute βhCG levels more than 80000mIU/mL (88935+7835.44; t=6.058; p<0.001) was observed. The chances of caesarean delivery increased with the severity of hypertension. Whereas only 20.6% normotensive women were delivered by LSCS; 11 (55.0%) out of a total of 20 women with gestational hypertension underwent LSCS (p <0.001). Conclusion: Elevated mid-trimester maternal serum βhCG levels could be used as a predictor of development and severity of hypertension in pregnancy.

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Evaluation of the variations and potential clinical use of second trimester serum markers for the detection of pre-eclampsia

Cited by 2 publications

References 14 publications

Association of Human Chorionic Gonadotrophin With Pregnancy Induced Hypertension

Association of Human Chorionic Gonadotrophin With Pregnancy Induced Hypertension

Correlation Between the Early Mid-Trimester (13-20 Weeks) Maternal Serum Beta-HCG Levels and the Developmentof Gestational Hypertension Later in the Pregnancy, a Prospective Observational Study.

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