Evaluation of the Wound Healing Potential ofResina Draconis (Dracaena cochinchinensis)in Animal Models

Abstract

Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, was treated with ointment base. Group II, which served as a reference standard, was treated with moist exposed burn ointment (MEBO). Group III was treated with RDEE. The parameters observed were percentage of wound contraction, epithelialization period, tensile strength, histopathological studies, microvessel density (MVD), and the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1). The group treated with RDEE showed significantly better wound contraction and better skin-breaking strength as compared with the control group. The results of histopathological examination, MVD, and the expression levels of growth factors supported the outcome of the wound models as well. The present study provided a scientific rationale for the traditional use of RD in the management of wounds.

Effect of Parkia biglobosa extract on open skin wound healing in dexamethasone- induced hyperglycaemia and histological assessment in rats

“…Studies conducted on the phytochemical screening of P. biglobosa showed the presence of phytoconstituents such as anthraquinones, tannins, flavonoids, terpenes, saponins, phenols and steroids (Builders et al, 2016); these may be attributed to the wound healing activity of P. biglobosa. The enhanced wound healing activity of this extract could be related to a function of either the individual or the additive effects of the phytoconstituents which is similar to research conducted by Liu et al (2013). These bioactives have been reported to possess pharmacological properties such as antimicrobial, antioxidant, analgesic, and anti-inflammatory activities which promote the wound-healing process mainly due to wound contraction and increased rate of epithelization (Liu et al, 2013).…”

Resina Draconis as a topical treatment for pressure ulcers: A systematic review and meta‐analysis

“…Our findings that RD has encouraging therapeutic effects for pressure ulcers compared with other dressings are inline with those of an earlier meta‐analysis on therapeutic effect of TCM conducted by Qian . Similarly, in a pharmacological study evaluating the wound healing potential of RD, Liu reported a significant reduction in wound size and mean epithelization time as well as the higher expression of growth factors in the RD treated group. Regarding adverse effects, our finding is also in agreement with a toxicology study conducted by Zeng .…”

“…Modern pharmacological studies have found that RD contains a variety of active ingredients such as flavonoids, triterpenoids, glycosides, stilbenes, organic acids, phenols, and esters . It possesses hemostatic activity, some analgesic effect, vasoactive‐antithrombotic potency, immunomodulatory activity and wound‐healing properties . RD has been frequently used in China, with the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, and replenishing blood.…”

The synergistic effect of am and mo derived gel in burn and wound healing

“…Different complex processes such as inflammation, epithelialization, angiogenesis, granulation, tissue formation and the deposition of interstitial matrix are involved for tissue repair and wound healing. 44 Microorganisms, especially bacteria (S. aureus and P. aeruginosa) are responsible for inflammatory response in both acute and chronic wounds and delay the wound healing process. The aqueous fraction of MO leaves contains some phytochemical compounds such as alkaloids, triterpenoids, tannins, and flavonoids.…”