Evaluation of thermal-oxidative stability and antiglioma activity of <i>Zanthoxylum tingoassuiba</i> essential oil entrapped into multi- and unilamellar liposomes

Detoni, Chaline; Oliveira, Diêgo Madureira de; Santo, Islane Espírito; Pedro, André São; El-Bachá, Ramon dos Santos; Velozo, Eudes da Silva; Ferreira, Domingos; Sarmento, Bruno; Albuquerque, Elaine Christine de Magalhães Cabral

doi:10.3109/08982104.2011.573793

Cited by 47 publications

(29 citation statements)

References 24 publications

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“…All loaded lipid vesicles showed narrow size distribution (PDI < 0.21), proving a good homogeneity and a low tendency of aggregation. The incorporation of SE extract improved the homogeneity, while the empty vesicles had a wider size distribution than SE-loaded vesicles in agreement with literature data [44,45]. The zeta potential values were in the range of −43 ± 1.03 mV ÷ −37 ± 0.23 mV being in accordance with the literature data, all samples indicated moderate stability [46].…”

Section: Characterization Of Se Extract−loaded Lipid Vesiclessupporting

confidence: 90%

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

et al. 2019

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The paper deals with the preparation and characterisation of hydroalcoholic polyphenolic extract from Sambucus ebulus (SE) leaves that was further loaded into three-types of lipid vesicles: liposomes, transfersomes, and ethosomes, to improve its bioavailability and achieve an optimum pharmacological effect. For Sambucus ebulus L.-loaded lipid vesicles, the entrapment efficiency, particle size, polydispersity index and stability were determined. All prepared lipid vesicles showed a good entrapment efficiency, in the range of 75–85%, nanometric size, low polydispersity indexes, and good stability over three months at 4 °C. The in vitro polyphenols released from lipid vehicles demonstrated slower kinetics when compared to the free extract dissolution in phosphate buffer solution at pH 7.4. Either free SE extract or SE extract loaded into lipid vesicles demonstrated a cytoprotective effect, even at low concentration, 5 ug/mL, against hydrogen peroxide-induced toxicity on L-929 mouse fibroblasts’ cell lines. However, the cytoprotective effect depended on the time of the cells pre-treatment with SE extract before exposure to a hydrogen peroxide solution of 50 mM concentration, requiring at least 12 h of pre-treatment with polyphenols with radical scavenging capacity.

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Section: Characterization Of Se Extract−loaded Lipid Vesiclessupporting

confidence: 90%

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

et al. 2019

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“…Exploration of natural plant products as an option to find new chemicals as anticancer agents is one of the fastest growing areas of research, and the available studies indicate EOs from various plant species and their constituents as anticancer agents [63]. A recent study has shown that EOs can be a potential alternative for glioblastoma treatment [64][65][66]. Quassinti et al [65] showed that EO of Hypericum hircinum had antiproliferative activity on human glioblastoma tumor cells T98G.…”

Section: Discussionmentioning

confidence: 99%

“…Quassinti et al [65] showed that EO of Hypericum hircinum had antiproliferative activity on human glioblastoma tumor cells T98G. Detoni et al [64] demonstrated that EO of Zanthoxylum tinguassuiba could be a potential alternative for gliobastoma treatment. As reported by Bayala et al [66], essential oil of Ageratum conyzoides shows the highest antitumor activity on SF-763 cells, while the SF-767 glioblastoma cell line was the most sensitive to EOs of Ocimum basilicum and Lippia multiflora.…”

Section: Discussionmentioning

confidence: 99%

Chemical Characteristics and Anticancer Activity of Essential Oil from Arnica Montana L. Rhizomes and Roots

et al. 2020

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Arnica montana L. is a medicinal plant with diverse biological activities commonly used in pharmacy and cosmetics. The attributes of A. montana are mainly related to the concentration and chemical composition of essential oils (EOs). Therefore, the objective of this study was to characterize the chemical composition of EOs derived from A. montana rhizomes and roots taking into account the age of the plants and to investigate the effect of the analyzed EOs on induction of apoptosis, necrosis, and autophagy in human glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cell lines. Rhizomes and roots of mountain arnica were harvested at the end of the third and fourth vegetation periods. The chemical composition of essential oils was determined with the GC–MS technique. Among the 37 components of the essential oil of A. montana, 2,5-dimethoxy-p-cymene (46.47%–60.31%), 2,6-diisopropylanisole (14.48%–23.10%), thymol methyl ether (5.31%–17.79%), p-methoxyheptanophenone (5.07%–9.65%), and α-isocomene (0.68%–2.87%), were detected in the rhizomes and roots of the three-year-old plants and in the rhizomes and roots of the four-year-old plants. The plant part (rhizome, root) and plant age can be determinants of the essential oil composition and, consequently, their biological activity. The induction of apoptosis (but not autophagy nor necrosis) at a level of 28.5%–32.3% is a promising result, for which 2,5-dimethoxy-p-cymene, 2,6-diisopropylanisole, thymol methyl ether, and p-methoxyheptanophenone are probably mainly responsible. The present study is the first report on the anticancer activities of essential oils from A. montana rhizomes and roots.

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“…In the present study, the phenyl propenes; estragole and isoeugenol, and the monoterpenes; eucalyptol, pulegone, terpineol, and thymol were chosen as models of essential oil components. These components exhibit considerable biological effects including antimicrobial, antifungal, antinociceptive, anti-inflammatory (Dogan et al 2017;Kfoury et al 2016;de Sousa et al 2011;Melo Júnior et al 2017;de Oliveira et al 2012;Wattanasatcha, Rengpipat, and Wanichwecharungruang 2012;Riella et al 2012) antioxidant (Kfoury et al 2014), and anesthetic (Reiner, Perillo, and García 2013) activities.…”

Section: Introductionmentioning

confidence: 99%

New findings on the incorporation of essential oil components into liposomes composed of lipoid S100 and cholesterol

Hammoud¹,

Gharib²,

Fourmentin³

et al. 2019

International Journal of Pharmaceutics

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The encapsulation of essential oil components into liposomes was demonstrated to improve their solubility and chemical stability. The aim of the present study is to investigate the effect of chemical structure, henry constant (H " ) value and aqueous solubility of essential oil components on their liposomal encapsulation. Based on ethanol injection method, the essential oil components (estragole, eucalyptol, isoeugenol, pulegone, terpineol, and thymol) were encapsulated in lipoid S100-liposomes. Static headspace gas chromatography method showed that H # of estragole, isoeugenol and eucalyptol was approximately 10 times greater than that of pulegone, terpineol and thymol. Besides, dynamic light scattering and diffraction technique revealed that all liposomal vesicles were of micrometric in size and the presence of phenols, isoeugenol and thymol, promoted enlargement of vesicles. Incorporation in liposomes was better (encapsulation efficiency > 90 %) for the essential oil components exhibiting low aqueous solubility, estragole, isoeugenol, and pulegone. Besides, efficient entrapment in liposomes (loading rate > 18 %) was obtained for isoeugenol, terpineol and thymol. This suggests that the presence of hydroxyl group in the structure and exhibiting lower H " ameliorated the entrapment of essential oil components into liposomes. Furthermore, release rate from liposomes varied among the investigated essential oil components and it was controlled by loading rate of essential oil components into liposomes, size of liposomal batches, location of essential oil components within lipid bilayer, and cholesterol incorporation rate of liposomes. Finally, liposomal encapsulation of isoeugenol, pulegone, terpineol, and thymol was suitable to protect them as a considerable concentration was retained in liposomes after 10 months with respect to initial concentration.

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Evaluation of thermal-oxidative stability and antiglioma activity of Zanthoxylum tingoassuiba essential oil entrapped into multi- and unilamellar liposomes

Cited by 47 publications

References 24 publications

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

Polyphenolic Extract from Sambucus ebulus L. Leaves Free and Loaded into Lipid Vesicles

Chemical Characteristics and Anticancer Activity of Essential Oil from Arnica Montana L. Rhizomes and Roots

New findings on the incorporation of essential oil components into liposomes composed of lipoid S100 and cholesterol

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