Evaluation of Thermal Properties of Ex Vivo Kidney up to Ablative Temperatures

Silva, Nuno P.; Bottiglieri, Anna; Porter, Emily; O’Halloran, Martin; Farina, Laura

doi:10.1007/978-3-030-64610-3_61

Cited by 6 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At higher temperatures (average value of 60 °C), k, D, and cv of the ex vivo swine kidney tissue were 0.560 ± 0.023 W/(m•K), 0.158 ± 0.007 mm 2 /s, and 3.55 ± 0.31 MJ/(m 3 •K), accordingly. The measured thermal properties are comparable with the thermal properties attained by Silva et al, who performed measurement adopting the dual-needle technique, in tissues of a different species, i.e., ovine kidney tissues, at room and body temperature [28] and up to ablative temperatures [27]. Overall, the observed higher uncertainty of liver tissues may be ascribable to the inter-sample variability and anisotropy characterizing the tissue specimens [7], [23].…”

Section: Resultssupporting

confidence: 83%

“…While different studies focused on the thermal characterization of liver tissue of various species as a function of temperature [7], [19], [20], [29], [34], a limited number of investigations reported the thermal properties of other organs, such as kidney, as a function of temperature [27], [28]. In this regard, after the validation of the measurement method in liver tissue, we measured the thermal properties of porcine kidney tissue (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, analyses with differential scanning calorimetry have been performed to investigate the specific heat capacity of tissues as well as the transition temperatures of biological components [25], [26]. Lastly, the so-called dual-needle technique has been adopted for the measurement of k, D, and cv by means of a dual-needle sensor located into tissue, allowing for both the heating of tissue and temperature monitoring [19], [20], [27]- [29]. Further evaluations are necessary to outline the thermal characteristic of tissues that are targets of thermal therapies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Measurement of thermal properties of biological tissues and tissue-mimicking phantom with a dual-needle sensor

Bianchi

Asadi

Landro

et al. 2022

2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

View full text Add to dashboard Cite

This work presents the measurement of the thermal properties of ex vivo biological tissues (i.e., porcine liver and kidney tissues) as a function of temperature, along with the thermal characterization of a tissue-mimicking agar-based phantom. The evaluation of the thermal properties was performed by the dual needle technique, adopting a sensor equipped with two needles, capable to deliver thermal energy to the biomaterial and monitor the related tissue thermal behavior. Measurements of thermal conductivity, thermal diffusivity, and volumetric heat capacity were conducted at room temperature and at temperatures relevant from a biological point of view, namely, body temperature and temperatures of ~60 °C-65 °C, which are typically correlated to instantaneous thermal damage in tissue. Thermal properties of biological tissue remained rather constant at the investigated temperatures: average values of thermal conductivity ranged from 0.515 W/(m•K) to 0.575 W/(m•K), thermal diffusivity ranged from 0.144 mm 2 /s to 0.163 mm 2 /s, whilst the average volumetric heat capacity was from 3.48 MJ/(m 3 •K) to 3.72 MJ/(m 3 •K). Furthermore, the thermal properties of the realized agar phantom were comparable to the ones of biological tissues. The results of this study provide valuable information for the characterization of porcine liver and kidney tissues, in terms of their thermal properties, to be used in predictive mathematical models of thermal therapies and validate the usage of agar phantoms as tissue-mimicking materials.

show abstract

Section: Resultssupporting

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Measurement of thermal properties of biological tissues and tissue-mimicking phantom with a dual-needle sensor

Bianchi

Asadi

Landro

et al. 2022

2022 IEEE International Symposium on Medical Measurements and Applications (MeMeA)

View full text Add to dashboard Cite

show abstract

“…At room temperature, a maximum percentage difference of 14% was observed in comparison with the values measured by Valvano et al (at 23 • C) in porcine renal cortex, rabbit kidney, human renal pelvis, human renal medulla, and human renal cortex using self-heating thermistor probes [35]. Moreover, a maximum difference of approximately 5% can be assessed by comparing our results and previous measurements of ovine kidney tissue [40] performed with the same dual-needle techniques employed in the present study. Table 6 shows the average values of α obtained in our investigation along with the results of other experimental trials performed on ex vivo ovine kidney, porcine renal cortex, rabbit kidney, human renal pelvis, human renal medulla, and human renal cortex [35,40].…”

Section: Discussionsupporting

confidence: 80%

Measurement of Thermal Conductivity and Thermal Diffusivity of Porcine and Bovine Kidney Tissues at Supraphysiological Temperatures up to 93 °C

Bianchi,

Fiorentini,

Gianella

et al. 2023

Sensors

View full text Add to dashboard Cite

This experimental study aimed to characterize the thermal properties of ex vivo porcine and bovine kidney tissues in steady-state heat transfer conditions in a wider thermal interval (23.2–92.8 °C) compared to previous investigations limited to 45 °C. Thermal properties, namely thermal conductivity (k) and thermal diffusivity (α), were measured in a temperature-controlled environment using a dual-needle probe connected to a commercial thermal property analyzer, using the transient hot-wire technique. The estimation of measurement uncertainty was performed along with the assessment of regression models describing the trend of measured quantities as a function of temperature to be used in simulations involving heat transfer in kidney tissue. A direct comparison of the thermal properties of the same tissue from two different species, i.e., porcine and bovine kidney tissues, with the same experimental transient hot-wire technique, was conducted to provide indications on the possible inter-species variabilities of k and α at different selected temperatures. Exponential fitting curves were selected to interpolate the measured values for both porcine and bovine kidney tissues, as well as for both k and α. The results show that the k and α values of the tissues remained rather constant from room temperature up to the onset of water evaporation, and a more marked increase was observed afterward. Indeed, at the highest investigated temperatures, i.e., 90.0–92.8 °C, the average k values were subject to 1.2- and 1.3-fold increases, compared to their nominal values at room temperature, in porcine and bovine kidney tissue, respectively. Moreover, at 90.0–92.8 °C, 1.4- and 1.2-fold increases in the average values of α, compared to baseline values, were observed for porcine and bovine kidney tissue, respectively. No statistically significant differences were found between the thermal properties of porcine and bovine kidney tissues at the same selected tissue temperatures despite their anatomical and structural differences. The provided quantitative values and best-fit regression models can be used to enhance the accuracy of the prediction capability of numerical models of thermal therapies. Furthermore, this study may provide insights into the refinement of protocols for the realization of tissue-mimicking phantoms and the choice of tissue models for bioheat transfer studies in experimental laboratories.

show abstract

“…Many scientific studies have been presented to measure the thermal properties of biological tissues. These studies are mainly focused on liver tissue [ 18 , 19 , 20 , 21 ] and muscles [ 22 , 23 , 24 , 25 ], and some data are reported for other organs, such as the kidney [ 26 ] and brain [ 27 ]. However, as mentioned before, most of these studies measured the thermal properties at a constant or low temperature which is not completely appropriate for thermal ablation modeling.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Ex Vivo Liver, Brain and Pancreas Thermal Properties as Function of Temperature

Mohammadi

Bianchi

Asadi

et al. 2021

Sensors

View full text Add to dashboard Cite

The ability to predict heat transfer during hyperthermal and ablative techniques for cancer treatment relies on understanding the thermal properties of biological tissue. In this work, the thermal properties of ex vivo liver, pancreas and brain tissues are reported as a function of temperature. The thermal diffusivity, thermal conductivity and volumetric heat capacity of these tissues were measured in the temperature range from 22 to around 97 °C. Concerning the pancreas, a phase change occurred around 45 °C; therefore, its thermal properties were investigated only until this temperature. Results indicate that the thermal properties of the liver and brain have a non-linear relationship with temperature in the investigated range. In these tissues, the thermal properties were almost constant until 60 to 70 °C and then gradually changed until 92 °C. In particular, the thermal conductivity increased by 100% for the brain and 60% for the liver up to 92 °C, while thermal diffusivity increased by 90% and 40%, respectively. However, the heat capacity did not significantly change in this temperature range. The thermal conductivity and thermal diffusivity were dramatically increased from 92 to 97 °C, which seems to be due to water vaporization and state transition in the tissues. Moreover, the measurement uncertainty, determined at each temperature, increased after 92 °C. In the temperature range of 22 to 45 °C, the thermal properties of pancreatic tissue did not change significantly, in accordance with the results for the brain and liver. For the three tissues, the best fit curves are provided with regression analysis based on measured data to predict the tissue thermal behavior. These curves describe the temperature dependency of tissue thermal properties in a temperature range relevant for hyperthermia and ablation treatments and may help in constructing more accurate models of bioheat transfer for optimization and pre-planning of thermal procedures.

show abstract

Evaluation of Thermal Properties of Ex Vivo Kidney up to Ablative Temperatures

Cited by 6 publications

References 16 publications

Measurement of thermal properties of biological tissues and tissue-mimicking phantom with a dual-needle sensor

Measurement of thermal properties of biological tissues and tissue-mimicking phantom with a dual-needle sensor

Measurement of Thermal Conductivity and Thermal Diffusivity of Porcine and Bovine Kidney Tissues at Supraphysiological Temperatures up to 93 °C

Measurement of Ex Vivo Liver, Brain and Pancreas Thermal Properties as Function of Temperature

Contact Info

Product

Resources

About