Evaluation of Thyroid Disease in Kidney Transplantation Candidates: Management and Follow-up

Veroux, Massimiliano; Giuffrida, G; Gagliano, M.; Giaquinta, Alessia; Tallarita, Tiziano; Sorbello, Massimiliano; Corona, Daniela; Zerbo, D.; Vizcarra, Darwin; Scriffignano, V.; Cannizzaro, Matteo Angelo

doi:10.1016/j.transproceed.2009.03.014

Cited by 7 publications

(9 citation statements)

References 11 publications

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“…This retrospective study included 760 patients who received kidney transplantation between January 2000 and October 2017. All ESRD patients, to be included in the waiting list, underwent ultrasonography of the neck and complete assessment of thyroid function according to serum levels of FT3, FT4, and TSH, as previously described [2]. In brief, all patients with a benign thyroid disease (nodular goiter or thyroiditis) were considered eligible for kidney transplantation after treatment of the disease, while patients with a diagnosis of thyroid cancer were considered eligible for kidney transplantation after at least 2 years of negative follow-up [2].…”

Section: Methodsmentioning

confidence: 99%

“…Surgical treatment was performed in kidney transplant recipients with a diagnosis of thyroid cancer or an uncertain diagnosis at FNAc, follicular adenoma, Plummer adenoma, or multinodular goiter and compressive symptoms on adjacent organs. Patients with benign disease, cystic lesions, or thyroid nodules smaller than 1 cm were followed up on yearly basis to evaluate thyroid function and perform ultrasonography [2].…”

Section: Methodsmentioning

confidence: 99%

“…Thyroid diseases may worsen after transplantation, mainly due to a consequence of the immunosuppression and this may probably explain the increased risk of thyroid cancer after transplantation [2,[8][9][10][11][12]. Interestingly, the risk of cancer in patients with ESRD is higher during dialysis period than during functioning kidney transplant intervals [13].…”

Section: Introductionmentioning

confidence: 99%

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Thyroid disease and cancer in kidney transplantation: a single-center analysis

et al. 2019

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Background: Thyroid diseases are frequent in patients with end-stage renal disease, but data on renal transplant recipients are conflicting. This study evaluated the incidence of thyroid disease and cancer in a population of kidney transplant recipients performed in a single center. Methods: Seven hundred sixty patients receiving a kidney transplantation between January 2000 and October 2017 were followed with thyroid ultrasonography to determine nodules together with thyroid hormone levels. Ultrasound-guided fine-needle aspiration citology (FNAc) was performed to the nodules > 10 mm. Results: Two hundred four patients (26.8%) patients demonstrated functional or morphologic changes in the thyroid gland compared with pre-transplant period. Among the 204 patients with newly diagnosed thyroid disease, 165 patients had single or multiple nodular lesions less than 1 cm in diameter, and were followed yearly. Nodule size progression was observed in 23 patients (13.9%), and they underwent a FNAc. A total of sixty-two patients (30.3%) underwent FNAc. The biopsy samples were cytologically interpreted as benign in 20 patients (32.2%), suspicious in 40 patients (64.5%), or at high risk of cancer in 2 patients (3.2%). Forty-two patients underwent total thyroidectomy. At histological examination, 18 patients had a thyroid cancer (papillary cancer in 17 patients, follicular cancer in one). Thyroid cancer was more frequent in male patients with a mean time from transplant to diagnosis of 5.6 years. At a mean follow-up was 8 ± 1.2 years, all patients are alive with a normal functioning graft. Conclusions: Thyroid diseases are common in transplant recipients. Thyroid disease may evolve after transplantation, probably as a consequence of immunosuppression. A complete evaluation of thyroid disease is mandatory in kidney transplant recipients because early diagnosis and appropriate treatment of thyroid disease and cancer may significantly decrease the morbidity and mortality in these patients.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thyroid disease and cancer in kidney transplantation: a single-center analysis

et al. 2019

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“…The rationale is that cancer, including thyroid, may be more clinically aggressive in transplant recipients than in the general population. 26,27 Thyroid cancer is the most common endocrine neoplasm. Most are differentiated thyroid cancers (DTC) that originate from the epithelial follicular cell.…”

Section: Thyroid Cancer In Transplant Candidates and Recipientsmentioning

confidence: 99%

“…41 One institution placed thyroid cancer patients on the renal transplant list 2 years after the initial treatment. 26 Within the past decade there is better understanding of how to risk-stratify thyroid cancer for recurrence by histology and genetic profiling. The improved methods for detecting DTC, such as sensitive thyroglobulin assays, ultrasound imaging, and FDG-PET, may better determine which thy- A transverse view ultrasound image shows that the right thyroid lobe contains a heterogeneous nodule (arrow) with irregular borders.…”

Section: Thyroid Cancer In Transplant Candidates and Recipientsmentioning

confidence: 99%