Evaluation of thyroid disorders in abnormal uterine bleeding

Abstract

Background: Abnormal uterine bleeding(AUB) is a common clinical presentation in gynecology. Alteration in thyroid hormones level has been associated with menstrual disturbances. This study is aimed to know the prevalence of thyroid disorders amongst AUB patients and also the different patterns of menstrual abnormalities associated with thyroid disorders.Methods: 100 Patient of clinically diagnosed AUB were taken from gynecology OPD. All the patients from 19 to 45 age groups presenting with menstrual disturbances were tested for thyroid function by measuring ST3, ST4, and S.TSH.Results: Out of 100 women of AUB, majority were in the age group of 31-40 years (38%), 54% were multiparous and 44% presented with menorrhagia. 65% were euthyroid, 17% had subclinical hypothyroidism, 15% had overt hypothyroidism and 3% were diagnosed as hyperthyroid. Subclinical hypothyroidism, overt hypothyroidism and hyperthyroidism were detected mostly in the age group of 31-40 years. The commonest bleeding abnormalities in hypothyroid patient were menorrhagia and polymenorrhoea. While most of the hyperthyroid cases were oligomenorrhoic.Conclusions: The study concludes that biochemical evaluation of thyroid function is an easy, reliable method and should be made mandatory in all cases of AUB.

Assessment Clinical Association of Thyroid Function in Women of Reproductive Age Group with Abnormal Uterine Bleeding

“…Similarly, statistically elevated percentage of hypothyroid patients (16/116) was reported than hyperthyroid patients (3/116), which are also in agreement of our results2 . The findings of a study are in accordance with our findings that AUB presented gyne patients were 65% euthyroid, 32% hypothyroid and 3% were hyperthyroid9 .…”

“…The genetic history of the patients for thyroid diseases was obtained and the weight as well as body mass index of the patients was also evaluated. The ultrasound of all the patients was done for ruling out any structural abnormality in the uterus or pelvic organs of the participants 9 . Moreover, the patients were urged to conduct diagnostic tests including complete blood count, blood biochemistry, blood sugar, and thyroid profile in particular for T3, T4 and TSH levels.…”

“…The menstrual cycle is based on the complex interaction of reproductive organs and endocrine system of the females and any disruption between these two systems, is the etiology of abnormal menstruation or AUB. The characteristic features of the AUB are: polymenorrhea (bleeding at less than 21 days interval), oligomenorrhea (bleeding at more than 35 days interval), menorrhagia (heavy blood flow of more than 80ml per cycle), metorrhagia (inter-menstrual irregular bleeding) and amenorrhea (stopped bleeding in non-menopause female patients) 9 . In early thyrotoxicosis, the reproductive associations are polymenorrhea and menorrhagia, while, in later and chronic stages amenorrhea develop in thyroid associated problems.…”

“…It was reported in a study that the female patients arriving with AUB were mostly complaining for menorrhagia (43%), followed by the bleeding pattern of ploymenorrhea (29%), oligomenorrhea (16.50%) and metorrhagia (2%) 16 . A study reported that the common type of bleeding pattern in the AUB patients is menorrhagia followed by polymenorrhea with the percentage of 44 and 16%, respectively 9 . Other studies also reported the same results that the AUB gyne patients were mostly complaining of menorrhagia and polymenorrhea with the percentage of 37.5, 46.15% and 22, 57.13%, respectively 22 .…”