Evaluation of tissue in repair with natural latex and / or hyaluronic acid in surgical bone defects

Issa, João Paulo Mardegan; Neto, Otavio Marino dos Santos; Macedo, Ana Paula; Gonzaga, Miliane Gonçalves; Pereira, Yamba Carla Lara; Feldman, Sara

doi:10.1590/0103-6440202104302

Cited by 2 publications

(2 citation statements)

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“…Hyaluronic acid , as an important component of the ECM, has been widely used in bone regeneration, in particular in the craniofacial and alveolar bone reconstruction [ 84 , 85 ]. This natural polymer can be effectively used as a cell-seeded scaffold or a carrier for bioactive components due to its elasticity, flexibility, and biocompatibility.…”

Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

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In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

et al. 2022

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Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical translation of BTE requires overcoming a number of significant challenges. Currently, insufficient vascularization is the critical limitation for viability of the bone tissue-engineered construct. Furthermore, efficacy and safety of the scaffolds cell-seeding and exogenous growth factors administration are still controversial. The in vivo bioreactor principle (IVB) is an exceptionally promising concept for the in vivo bone tissue regeneration in a predictable patient-specific manner. This concept is based on the self-regenerative capacity of the human body, and combines flap prefabrication and axial vascularization strategies. Multiple experimental studies on in vivo BTE strategies presented in this review demonstrate the efficacy of this approach. Routine clinical application of the in vivo bioreactor principle is the future direction of BTE; however, it requires further investigation for to overcome some significant limitations.

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Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

“…This natural polymer can be effectively used as a cell-seeded scaffold or a carrier for bioactive components due to its elasticity, flexibility, and biocompatibility. Furthermore, hyaluronic acid promotes and accelerates angiogenesis and cell migration [ 84 , 85 ].…”

Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

et al. 2022

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Medicina regenerativa de cartílago: efecto del tratamiento con ácido hialurónico reticulado bifásico en lesiones osteocondrales

Álvarez,

Francioni,

Operti

et al. 2024

Rev. Asoc. Arg. Ort. y Traumatol

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Objetivo: Evaluar si el tratamiento con ácido hialurónico reticulado bifásico de lesiones osteocondrales promovería la regeneración del tejido cartilaginoso, favoreciendo así la reparación de la lesión. Materiales y Métodos: Quince conejos hembra adultos fueron divididos aleatoriamente en tres grupos: grupo 1, de control; grupo 2 y grupo 3, sometidos a una estrategia quirúrgica de lesión osteocondral en la rodilla derecha (4 mm de diámetro, 5 mm de profundidad), el grupo 3 recibió tratamiento con 0,2 ml de ácido hialurónico por vía intrarticular después de la cirugía. Se realizaron controles clínicos, bioquímicos, histopatológicos y estudios por imágenes. Resultados: Se detectaron menos casos de dolor a la palpación en el grupo 3 que en el grupo 2 a partir de los 45 días. En la resonancia magnética, casi todas las muestras del grupo 3 tenían signos de regeneración del tejido cartilaginoso en el sitio de la lesión, sin edema óseo, ni derrame articular significativo. Los estudios histopatológicos de las muestras del grupo 3 indicaron un aumento de la matriz extracelular propia de tejido cartilaginoso, comparada con la del grupo 2, con hipercelularidad, dada por condrocitos, los que formaban grupos isogénicos axiales y coronales. Conclusiones: Este estudio brinda evidencias de que el tratamiento con ácido hialurónico reticulado bifásico en unidades experimentales de conejos con lesión osteocondral no tuvieron dolor en etapas tempranas después de la lesión, a diferencia de las unidades intervenidas y sin dicho tratamiento. A su vez, los estudios por imágenes e histopatológico mostraron la reparación del tejido dañado.

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Evaluation of tissue in repair with natural latex and / or hyaluronic acid in surgical bone defects

Cited by 2 publications

References 50 publications

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

Medicina regenerativa de cartílago: efecto del tratamiento con ácido hialurónico reticulado bifásico en lesiones osteocondrales

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