Evaluation of Topical Application of Platelets Rich Plasma and Hyaluronic Acid on the Healing of Experimentally Induced Tongue Ulcer

Elgamal, Asmaa; Amin, Laila E

doi:10.21608/edj.2021.97512.1798

Cited by 1 publication

(3 citation statements)

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“…Group II: 10 rats subjected to tongue ulcer and then the ulcers were treated with 3 times/ day topical applications of commercially used 0.2% high molecular weight hyaluronic acid (17) .…”

Section: Methodsmentioning

confidence: 99%

“…The active ingredient in it is a High Molecular Weight (HMW) hyaluronic acid in a form of sodium hyaluronate. The other ingredients are: Aqua, Xylitol, Celleluse Gum, Alcohol, Peg 40 Hydrogenated Castor Oil, Dichlorobenzyl Alcohol, Carbomer, Aroma, Citric Acid, Sodium Hydroxide and Acidic Blue (17) .…”

Section: Ha Preparationmentioning

confidence: 99%

“…Scarification of rats was done by overdose of sodium thiopental at day 4 and 10 respectively (17) after ulcer induction, tongue was excised from each animal and quickly immersed in 10% formalin solution and become ready for histological examination, and immunohistochemically for alpha smooth muscle actin (α-SMA).…”

Section: Ulcer Inductionmentioning

confidence: 99%

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Impact of Hyaluronic acid on healing of tongue ulcers in diabetic rats

Moawad

Abobaker

2022

Egyptian Dental Journal

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Introduction: Wound healing is a highly complicated process achieved through definitely programmed stages. Hyaluronic acid is a natural component present essentially in the skin and other connective tissues, it has been used in many medical fields for acceleration of wound healing.Aim: This study aimed to investigate the therapeutic effect of hyaluronic acid on healing of tongue ulcer in diabetic rat model. Material & Methods:Thirty male Albino rats were subjected to diabetes induction and after 1 week the animals were classified into 3 groups, Group I: rats were subjected to tongue ulcer and did not receive any treatment. Group II: rats were subjected to tongue ulcer and the ulcers were treated with 3 times/ day topical applications of commercially used 0.2% high molecular weight hyaluronic acid. Group III: rats were received 1-2 IU/ g/day of insulin NPH injected subcutaneous and then subjected to tongue ulcer after one week from the starting of insulin injection. The animals were sacrificed at 4 and 10 days after ulcer induction, specimens were prepared for histological examination and immunohistochemical staining for α-SMA.Results: Histological examination revealed better enhancement of ulcer healing and reepithelization together with reorganization of the epithelium and connective tissue in group II and III samples when compared to group I after 4 and 10 days of ulcer induction. Conclusion:oral application of hyaluronic acid gel has beneficial effects in accelerating wound healing and improving all phases of wound repair in tongue ulcers in rats.

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“…Group II: 10 rats subjected to tongue ulcer and then the ulcers were treated with 3 times/ day topical applications of commercially used 0.2% high molecular weight hyaluronic acid (17) .…”

Section: Methodsmentioning

confidence: 99%

Section: Ha Preparationmentioning

confidence: 99%