Evaluation of Total Antioxidant Capacity of Saliva in High School Students

Rahmani, Mahmoud; Ghorchi, Vahideh; Rezaei, Fatemeh; Vaisi-Raygani, Asad

doi:10.5539/gjhs.v8n4p89

Cited by 23 publications

(26 citation statements)

References 29 publications

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“…TAC in saliva of S-ECC children [12] and in children (mean age 2.74 years) with cavitated carious lesions [31] have been reported to be higher than in cariesfree children or in those with noncavitated lesions. However, in patients with carious lesions, salivary TAC tends to decrease as compared to caries-free patients [42]. Surprisingly, individuals aged 15-19 years old with active caries lesion cavities present similar salivary TAC (0.17 mol/mL) compared to those without carious lesions (0.17 mol/mL) [31], suggesting that age may be an important factor in salivary TAC quantification.…”

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confidence: 92%

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Araujo

Nakamune

Garcia

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress biomarkers can be found at detectable concentrations in saliva. These salivary biomarkers reflect specific oxidation pathways associated with caries and periodontitis. Our study evaluated the influence of dental caries severity (assessed using the ICCMS™ criteria) on the levels of oxidative stress biomarkers in saliva from children. Unstimulated saliva samples were collected from patients (from one to three years old) in a day care center in Birigui, SP, Brazil, two hours after fasting. Children were divided into four groups (n=30/group), according to caries severity: caries free (group A), early carious lesions (group B), moderate carious lesions (group C), and advanced carious lesions (group D). The following salivary biomarkers were determined: total proteins (TP), measured by the Lowry method; oxidative damage, measured by the TBARS method; total antioxidant capacity (TAC); superoxide dismutase (SOD) enzymatic antioxidant activity; and uric acid (UA) non-enzymatic antioxidant activity. Data were analyzed by ANOVA, followed by the Student-Newman-Keuls test, Pearson and Spearman correlation coefficients, and multivariable linear regression (p<0.05). TP, TAC, SOD enzymatic antioxidant activity, and UA non-enzymatic antioxidant activity increased with caries severity, consequently reducing salivary oxidative damage. It was concluded that higher caries severity increases salivary antioxidant system activity, with consequent reduction in salivary oxidative damage.

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confidence: 92%

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Araujo

Nakamune

Garcia

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…It contains composition such as has inflammatory mediators that play important role in oral health. Saliva composition, naturally or under certain conditions, varies in different individuals [ 33 , 34 ]. The relationship between some inflammatory mediators in saliva and periodontitis pathogenesis has been established in some studies.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis

Eivazi¹,

Falahi²,

Eivazi³

et al. 2017

TODENTJ

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Objective:Periodontitis is one of the main diseases in the oral cavity that causes tooth loss. The host immune response and inflammatory factors have important role in periodontal tissue. The current study was done with the objective to determine the effect of scaling and root planning on the salivary concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-alpha (IL-1α).Methods:In this quasi-experimental clinical trial, 29 patients with chronic periodontitis and 29 healthy subjects without periodontitis were studied. Clinical examination findings and salivary TNF-α and IL-1α (using ELISA method) were compared before and after scaling, root planning.Results:Before starting treatment, salivary TNF-α and IL-1α concentrations were higher in healthy control group than in periodontitis group (P< 0.05). Non-surgical treatment increased the concentration of these two biomarkers in the saliva. However, increase in IL-1α concentration was not statistically significant (P= 0.056). There was a negative relationship between TNF-α and IL-1α levels with pocket depth and attachment loss (P< 0.05).Conclusion:Scaling and root planning improved periodontal disease indices and salivary TNF-α and IL-1α levels.

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“…Unstimulated saliva could be the better approach to measure salivary TAC (PELUSO & RAGUZZINI [14], RAHMANI & al. [15]). The use of the DPPH assay provides an easy and rapid way to evaluate antioxidants by spectrophotometry, so it can be useful to assess various products at a time (GAWRON-SKARBEK & al.…”

Section: Discussionmentioning

confidence: 99%

Studies regarding salivary total antioxidant activity in different types of orthodontic treatement

RĀDUCANU¹,

Mihai²,

CARAIANE³

et al. 2019

Rom Biotechnol Lett.

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The defensive mechanism of the human body includes a wide range of antioxidants (non-enzymatic and enzymatic) that can eliminate reactive oxygen species and prevent their harmful consequences on the host. Total antioxidant capacity (TAC) is a biomarker used to measure the antioxidant potential of body fluids and it may be the most relevant parameter for assessing the defense capabilities. Because of the cumulative effect of antioxidants, it is better to measure the combined activity of all the antioxidants (total antioxidant capacity) instead of measuring the activity of each agent separated. The aim of this study is to investigate the effect of different orthodontic appliances (fixed and removable-aligners) on salivary total antioxidant capacity and if is a correlation between TAC and oral injuries made by them. Three groups of subjects have been tested: one group of ten patients with metallic fixed appliances, one group of ten patients with aligners, and a control group consisting in ten subjects. 2,2-diphenyl-1-picrylhydrazyl (DPPH) method was used for TAC assessment and salivary samples were obtained from all individuals before treatment, at two weeks from the beginning, at one and two month of treatment. Also, it was quantified the presence of the injuries in the mucosa (clinical parameter). The result shows that different types of orthodontic appliances increase differently the TAC and seems to be influenced by the injuries. KeywordsTotal antioxidant capacity (TAC), DPPH method, orthodontic aligners, fixed appliances.To cite this article: MĀDĀLINA RA, SEBASTIAN M, AURELIANA C, VICTORIA B.Studies regarding salivary total antioxidant activity in different types of orthodontic treatement.

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Evaluation of Total Antioxidant Capacity of Saliva in High School Students

Cited by 23 publications

References 29 publications

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

The Effect of Scaling and Root Planning on Salivary TNF-α and IL-1α Concentrations in Patients with Chronic Periodontitis

Studies regarding salivary total antioxidant activity in different types of orthodontic treatement

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