Evaluation of Toxicity and Neural Uptake In Vitro and In Vivo of Superparamagnetic Iron Oxide Nanoparticles

Khalid, Muhammad Kamran; Asad, Muhammad; Henrich‐Noack, Petra; Sokolov, Maxim; Hintz, Werner; Grigartzik, Lisa; Zhang, Enqi; Dityatev, Alexander; Wachem, Berend van; Sabel, Bernhard A.

doi:10.3390/ijms19092613

Cited by 32 publications

(22 citation statements)

References 37 publications

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“…Conversely, Dextran-coated SPIONs (10–50 nm) showed to be safer, did not impair the hippocampal cell viability at low doses after 24 h of incubation [113], which confirm the positive effect of the polymeric coating [4,108], as also discussed in Section 4.3.…”

Section: Discussionmentioning

confidence: 61%

“…The majority of neurotoxicity studies on IONPs are performed in 2-dimensional in vitro cultures [83,85,109,112,113]. There is, however, an increasing interest on co-cultured and 3-dimensional cells cultures, which are more realistic models with respect to 2D systems [114,115], extended also to other types of inorganic NPs, such as silica NPs [116].…”

Section: Discussionmentioning

confidence: 99%

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Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

et al. 2019

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Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

et al. 2019

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“…The in vitro biocompatibility experiments indicated a proper dosage during in vivo experiments. In our in vivo experiments, 5 nm USPIO nanoparticles were intravenously injected into rat at ∼1.8 mg·Fe/kg dosage, which could be translated into ∼26.4 μ g·Fe/mL blood volume [43]. Such dosage was well located in a safe range for a good biocompatibility and less nonspecific uptake by normal hepatic cells.…”

Section: Discussionmentioning

confidence: 99%

Imaging Characteristics of USPIO Nanoparticles (<5 nm) as MR Contrast Agent In Vitro and in the Liver of Rats

Wang

et al. 2019

Contrast Media & Molecular Imaging

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Iron nanoparticles have an increasingly more and more important role in MR molecular imaging due to their novel magnetic and surface chemical properties. They provide new possibilities for noninvasive diagnosis and treatment monitoring, especially for tissues that are rich in macrophages. The smaller size and prolongation of the plasma half-life change the in vivo fate of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles captured by liver in reticuloendothelial system (RES) or mononuclear phagocytic system (MPS). However, there is still a lack of MR imaging studies on the liver assessing USPIO nanoparticles <5 nm in size to reflect its absorption and clearance properties. In this study, we used MRI to study the in vitro phantom and in vivo rat liver imaging characteristics of USPIO nanoparticles (<5 nm). The results showed that USPIO nanoparticles (<5 nm) could potentially reduce longitudinal and transverse relaxation times and showed similar T1 relaxation rates compared with commercial gadolinium chelates. In addition, USPIO nanoparticles (<5 nm) in vivo demonstrated both positive (T1) and negative (T2) liver contrast enhancement in healthy rats’ liver. Furthermore, USPIO nanoparticles showed relatively good in vitro biocompatibility and fast clearance (within 45.17 minutes after intravenous injection) in the normal liver. Taken together, these data might inspire a new personalized and precise diagnostic tool and stimulate new applications for specific targeted molecular probes.

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“…Certainly, IONPs toxicity depends on many factors such as size, shape, surface chemistry, and chemical compositions, which can be modified. For example, coating the IONPs with different substances such as PEG and dextran can efficiently reduce the toxic effect of IONPs (Khalid et al 2018;Pisanic Ii et al 2007).…”

Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review

Arzaghi

Adel

Jafari

et al. 2020

Reviews in the Neurosciences

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The nervous system, which consists of a complex network of millions of neurons, is one of the most highly intricate systems in the body. This complex network is responsible for the physiological and cognitive functions of the human body. Following injuries or degenerative diseases, damage to the nervous system is overwhelming because of its complexity and its limited regeneration capacity. However, neural tissue engineering currently has some capacities for repairing nerve deficits and promoting neural regeneration, with more developments in the future. Nevertheless, controlling the guidance of stem cell proliferation and differentiation is a challenging step towards this goal. Nanomaterials have the potential for the guidance of the stem cells towards the neural lineage which can overcome the pitfalls of the classical methods since they provide a unique microenvironment that facilitates cell–matrix and cell–cell interaction, and they can manipulate the cell signaling mechanisms to control stem cells’ fate. In this article, the suitable cell sources and microenvironment cues for neuronal tissue engineering were examined. Afterward, the nanomaterials that impact stem cell proliferation and differentiation towards neuronal lineage were reviewed.

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Evaluation of Toxicity and Neural Uptake In Vitro and In Vivo of Superparamagnetic Iron Oxide Nanoparticles

Cited by 32 publications

References 37 publications

Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Imaging Characteristics of USPIO Nanoparticles (<5 nm) as MR Contrast Agent In Vitro and in the Liver of Rats

Nanomaterial integration into the scaffolding materials for nerve tissue engineering: a review

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