Evaluation of transcutaneous electrical simulation to improve recovery from corneal hypoesthesia after LASIK

Ghaffariyeh, Alireza; Peyman, Alireza; Puyan, Sadollah; Honarpisheh, Nazafarin; Bagheri, Babak; Peyman, Mohammadreza

doi:10.1007/s00417-009-1079-5

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…While no studies have reported on an ICT modality for ocular pain, we found four reports describing the use of TENS in the setting of ocular pathology and two that studied the effects of TENS in ocular pain (33)(34)(35)(36). Although the latter two reported pain relief, the first of these investigated the more invasive subcutaneous application of electrical current and the second from 1991 involved only ten cases in the setting of acute surgical pain (33,34).…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia

Sivanesan

Levitt

Sarantopoulos

et al. 2018

Neuromodulation: Technology at the Neural Interface

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Our data indicate that TENS may similarly provide analgesia in patients with dry eye symptoms as it does for many other chronic pain conditions. Furthermore, the noted effect on symptoms of photophobia and dryness suggest that all may be linked by similar trigeminal-thalamic-cortical pathways. Prospective studies with electrical stimulation of dry eye are needed to further elucidate its benefit and mechanism of action.

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Section: Introductionmentioning

confidence: 99%

Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia

Sivanesan

Levitt

Sarantopoulos

et al. 2018

Neuromodulation: Technology at the Neural Interface

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“…They applied electrical stimulation of continuous 20-Hz rectangular, biphasic wave pulses for 60 minutes. 30 Corneal sensitivity was significantly improved in comparison with the control group at 3 months after surgery (32 ± 13 mm improvement). 30 This is consistent with the findings of improved corneal sensitivity in the groups applied with 2-Hz and 20-Hz electrical stimulations in this study.…”

Section: Discussionmentioning

confidence: 82%

“… 28 , 29 In particular, Ghaffariyeh et al reported that transcutaneous electrical stimulation (TES) improved recovery of corneal nerve sensitivity at 3 months after surgery. 30 It could be suggested that the corneal nerve regeneration was accelerated by electrical stimulation. Although the functional recovery of the corneal nerves by electrical stimulation has been revealed, the structural recovery of the corneal nerves and the physiological mechanism by which electrical stimulation acts on corneal nerve recovery have not yet been revealed.…”

Section: Introductionmentioning

confidence: 99%

Corneal Neuro-Regenerative Effect of Transcutaneous Electrical Stimulation in Rabbit Lamellar Keratectomy Model

Yoo

Park

Eun

et al. 2022

Trans. Vis. Sci. Tech.

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Purpose This study aimed to evaluate the effect of transcutaneous electrical stimulation (TES) on corneal nerve regeneration in rabbits injured from superficial lamellar keratectomy (SLK). Methods New Zealand White rabbits were used in this experimental study. To induce corneal nerve damage, SLK was performed using a 7.0-mm trephine. TES was applied for 28 days after the corneal nerve injury. Corneal sensitivity, Western blotting, real-time polymerase chain reaction (PCR), and immunofluorescence were performed to observe changes in the corneal tissue. Results In the 2-Hz and 20-Hz electrical stimulation groups, the degree of corneal wound healing increased by more than 10% compared to the control group, but no significant difference was observed. Conversely, the electrical stimulation (2-Hz or 20-Hz) group showed significantly increased corneal sensitivity compared to the control group. Western blot analysis revealed that small proline-rich protein 1A (SPRR1a), a regeneration-associated protein was significantly increased in the 2-Hz group on days 1 and 7 compared to that in the other groups. Once again, nerve regeneration in the 2-Hz group was supported by the results of PCR, in which a significant increase in the nerve growth factor (NGF) on day 1 was observed compared with the other groups. Moreover, immunofluorescence after 28 days of electrical stimulation showed significant nerve regeneration in the 2-Hz group. Conclusions TES promoted corneal nerve regeneration in rabbit SLK model. The application of electrical stimulation of 2-Hz frequency was more effective than the 20-Hz frequency, showing potential clinical applications for corneal diseases. Translational Relevance This study shows how application of TES to the eyes that exhibit corneal nerve damage can improve corneal nerve regeneration examined by histologic analysis.

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“…It is a non-invasive form of neuromodulation that has demonstrated effectiveness in numerous pain conditions and has been widely used over recent decades (12)(13)(14)(15). TES also has been used for treating ocular diseases with promising results (7,16,17).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of transcutaneous electrical stimulation combined with artificial tears for the treatment of dry eye: A randomized controlled trial

Cai¹,

Zhang²

2020

Exp Ther Med

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There is currently no available cure or universally effective treatment for dry eye (DE). The aim of the present study was to investigate the clinical efficacy of transcutaneous electrical stimulation (TES) combined with artificial tears in treating DE. Patients diagnosed with DE were referred for therapy with TES combined with sodium hyaluronate (SH)-containing artificial tears. A total of 52 patients (104 eyes) with DE were enrolled in this randomized controlled trial. The patients were randomized 1:1 to the TES + SH or SH group. The patients in the TES + SH group were treated with 20 sessions (5 sessions per week for 4 weeks), and each session lasted for 20 min. The treatment was continued for 4 weeks in all cases. The Ocular Surface Disease Index (OSDI), tear film breakup time (BUT), Schirmer's I test and corneal fluorescein scores were used to assess treatment efficacy. A total of 90 eyes of 45 patients completed all aspects of the study: 22 patients (44 eyes) in the TES + SH group and 23 patients (46 eyes) in the SH group. There was no statistically significant difference in sex, age or course between the two groups. The mean OSDI scores, BUT, Schirmer's I test and corneal fluorescein scores exhibited a significant improvement in the TES + SH group compared with the SH group after treatment. No serious adverse events were recorded during TES treatment. In conclusion, TES combined with artificial tears appeared to be an effective treatment for DE. Therefore, TES may represent a new therapeutic option with promising potential applications.

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Evaluation of transcutaneous electrical simulation to improve recovery from corneal hypoesthesia after LASIK

Abstract: Transcutaneous electrical stimulation significantly improves corneal sensitivity at 3 months after LASIK. This may be due to accelerated corneal nerve regeneration by electrical stimulation.

Cited by 6 publications

References 30 publications

Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia

Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia

Corneal Neuro-Regenerative Effect of Transcutaneous Electrical Stimulation in Rabbit Lamellar Keratectomy Model

Effectiveness of transcutaneous electrical stimulation combined with artificial tears for the treatment of dry eye: A randomized controlled trial

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