Evaluation of Tumor Stiffness by Elastography Is Predictive for Pathologic Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer

Hayashi, Mitsuhiro; Yamamoto, Yutaka; Ibusuki, Mutsuko; Fujiwara, Saori; Yamamoto, Shuichi; Tomita, Shunsuke; Nakano, Masahiro; Murakami, Keiichi; Iyama, Ken Ichi; Iwase, Hirotaka

doi:10.1245/s10434-012-2343-1

Cited by 94 publications

(81 citation statements)

References 32 publications

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“…Hayashi et al (15) reported that the mean breast elastography scores were significantly lower for the clinical and pathologic complete response groups than for the other groups. Tumor stiffness assessed by elastography was potentially predictive for the response to NACT.…”

Section: Discussionmentioning

confidence: 99%

Elastography, a sensitive tool for the evaluation of neoadjuvant chemotherapy in patients with high-grade serous ovarian carcinoma

et al. 2014

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The aim of the present study was to evaluate tumor stiffness by ultrasound elastography, which has the potential to provide additional information that is useful in predicting the response to neoadjuvant chemotherapy (NACT) in high-grade serous ovarian carcinoma (HGSC) patients. In total, 32 patients with International Federation of Gynecology and Obstetrics stage III and IV epithelial ovarian cancer treated with NACT underwent transvaginal and transabdominal sonography, followed by elastography and finally, by interval cytoreductive surgery. Histopathological analysis revealed 24 (75%) HGSCs. The mean elasticity score was statistically higher for the post-NACT lesions than for the pre-NACT lesions (3.13±0.57 vs. 2.04±0.51, respectively; P<0.001). The median elasticity score for the pre-NACT lesions on the four-point scale was 2, and the score for the post-NACT lesions was 4. Cases of post-NACT with scores of 3 and 4 had a higher optimal cytoreduction rate than cases with scores of 1 and 2 (93.8 vs. 25.0%, respectively; P<0.001). When the post-NACT elasticity scores of 3 and 4 were used for the prediction of optimal cytoreduction, elastography exhibited 88.2% sensitivity, 85.7% specificity, a 93.8% positive predictive value, a 75.0% negative predictive value and 87.5% accuracy. The results of the current study suggested that elastography is a sensitive tool for the evaluation of NACT in patients with HGSC and that it may aid gynecologists in choosing the optimal cytoreduction.

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Section: Discussionmentioning

confidence: 99%

Elastography, a sensitive tool for the evaluation of neoadjuvant chemotherapy in patients with high-grade serous ovarian carcinoma

et al. 2014

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“…In ER-breast cancers, gene expression patterns typical of reactive stroma predicted resistance to chemotherapy, though no link was found between this signature and outcome in untreated patients [10]. Similarly, tumor stiffness measured with ultrasound elastography predicted residual tumor burden after chemotherapy [104][105][106]. Interestingly, clinical response to chemotherapy involved a softening of the tumor site, whereas resistant tumors became stiffer after treatment [93].…”

Section: Ecm and Chemotherapymentioning

confidence: 99%

The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking

Robertson

2016

Experimental Cell Research

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The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking a b s t r a c tThe extracellular matrix in the healthy breast has an important tumor suppressive role, whereas the abnormal ECM in tumors can promote aggressiveness, and has been linked to breast cancer relapse, survival and resistance to chemotherapy. This review article gives an overview of the elements of the ECM which have been linked to prognosis of breast cancers, including changes in ECM protein composition, splicing, and microstructure. Published by Elsevier Inc.

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“…Both techniques have been reported to be able to improve breast lesion characterization (Berg et al 2012;Chang et al 2011;Evans et al 2012;Itoh et al 2006). It has recently been found that pre-treatment elastography can predict response to neo-adjuvant therapy in women with invasive breast cancers (Evans et al 2013;Hayashi et al 2012). It has been also suggested that modifications of elastography under treatment could be used to assess therapy response in breast cancer patients (Athanasiou et al 2015;Falou et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Supersonic Shear Wave Elastography of Response to Anti-cancer Therapy in a Xenograft Tumor Model

Chamming’s

Lefrère-Belda

Latorre-Ossa

et al. 2016

Ultrasound in Medicine & Biology

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Evaluation of Tumor Stiffness by Elastography Is Predictive for Pathologic Complete Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer

Abstract: Tumor stiffness evaluated by EG bears predictive potential for response to neoadjuvant chemotherapy. Stiffness evaluated by EG may be recognized as a clinically significant tumor characteristic, comparable to other data obtained by functional imaging techniques.

Cited by 94 publications

References 32 publications

Elastography, a sensitive tool for the evaluation of neoadjuvant chemotherapy in patients with high-grade serous ovarian carcinoma

Elastography, a sensitive tool for the evaluation of neoadjuvant chemotherapy in patients with high-grade serous ovarian carcinoma

The extracellular matrix in breast cancer predicts prognosis through composition, splicing, and crosslinking

Supersonic Shear Wave Elastography of Response to Anti-cancer Therapy in a Xenograft Tumor Model

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