The optimization of forced ventilation in tunnel construction becomes the key problem to improve the construction environment and energy saving. The influence of main factors on the flow field is considered for orthogonal experimental design and optimization, which includes the distance between the air duct outlet and the tunnel face, the bench length, the bench height, and the position of the air duct. Thus, the TOPSIS theory was adopted for the optimization method and improvement, and a series of CFD simulations were applied to analyze optimal solutions. The results show that the improved TOPSIS theory with entropy weight method and analytic hierarchy process could effectively solve the optimization problem of forced ventilation in tunnel construction. Based on this optimization principle, a case was analyzed, and the optimized ventilation parameters are obtained to improve ventilation efficiency and save energy. In the optimization scheme, the flow field in the tunnel is stable and the wind is strong enough to ventilate. Besides, there is none huge vortex, which might disrupt the stable flow field and reduce energy efficiency. It could improve the ventilation efficiency and stability, save time and cost, and bring considerable economic and social benefits to the tunnel construction.