Evaluation of Undifferentiated Carcinoma of Nasopharyngeal Type with Thallium‐201 and Technetium‐99m MIBI SPECT

Šobić-Šaranović, Dragana; Pendjer, Ivica; Kozarevic, N.; Artiko, Vera; Mikić, Aleksandar; Obradović, Vladimir

doi:10.1016/j.otohns.2007.03.026

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…Finally, other researchers suggested that both 201 Tl and 99m Tc-MIBI have the same accuracies in locating primary, recurrent and lymph node involvement and thus could also be valuable. [24] In the study, no relation of the 99m Tc-TF sensitivity with the pathological grade of the tumor was observed, but there was a potential correlation of 99m Tc-TF sensitivity with tumor size. Thus, it appeared to be a trend toward positive uptake with increasing tumor size, which did not reach statistical significance, probably a result of a relatively small number of cases.…”

Section: Discussionmentioning

confidence: 67%

The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

Sioka¹,

Exarchopoulos²,

Skloupiotis³

et al. 2016

JCMT

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Aim:To evaluate the diagnostic value of technetium Tc99m-tetrofosmin ( 99m Tc-TF) in primary cancers of the head and neck. Methods: Single photon emission computer tomography with planar imaging of the neck for primary site evaluation and whole body scanning for assessment of metastases in 12 patients with newly diagnosed head and neck cancer. Tumor-to-background index (T/Bg) was derived in patients with positive findings (tumor or lymph nodes). Results: The tomographic images showed increased tracer uptake in pathological sites (primary tumor or lymph node) in 9 patients (overall sensitivity 75%). Primary tumor was visualised in 7 patients (sensitivity 58%) and infiltrated lymph nodes in 4 out 7 patients (sensitivity 57%). Mean values for T/Bg index were 5.44 ± 1.28 for primary tumor and 4.25 ± 1.67 for lymph nodes. Mean values for T/Bg index were 4.5 ± 0.71 for patients with in situ and grade I carcinoma and 6.68 ± 0.36 for patients with tumor grade II and III (P = 0.034, Mann-Whitney U test). Conclusion: The present study demonstrates that 99m Tc-TF is a valuable radiotracer for head and neck cancer imaging. To determine the potential role of this imaging protocol in clinical practice will require a larger sample size.

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Section: Discussionmentioning

confidence: 67%

The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

Sioka¹,

Exarchopoulos²,

Skloupiotis³

et al. 2016

JCMT

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“…In the 18 patients studied by Kostakoglu and colleagues, 201 Tl yielded the lowest diagnostic accuracy (72% and 71% at 3 and 6 months post‐treatment). In a later study with a larger sample of 46 NPC patients, Sobic‐Saranovic and colleagues presented differing results demonstrating that the specificity, sensitivity, and accuracy of 201 Tl was actually similar to that of MIBI SPECT imaging (88%, 78%, and 82% versus 86%, 77%, and 81%) 44 . It is unclear, however, if these results can be directly compared to the earlier study performed by Kostakoglu et al as patients in the latter study were subdivided into two groups to receive different imaging modalities (either MIBI SPECT or 201 Tl) rather than both imaging modalities due to the limited availability of tracers and high radiation exposure.…”

Section: Resultsmentioning

confidence: 97%

“… Detection of local recurrence: Optional. Similar to FDG‐PET, TC‐99m MIBI and 201 Tl SPECT detect cancerous tissues based on metabolic activity ( 201 Tl accumulates in cells with high Na‐K‐ATPase activity whereas TC‐99m MIBI concentrates in the mitochondria of tumor tissues) instead of morphological changes 44 . For indeterminate MRI findings, TC‐99m MIBI and 201 Tl SPECT can serve as an adjunctive alternative 43 …”

Section: Resultsmentioning

confidence: 99%

“…Detection of regional recurrence: Optional. 201 Tl SPECT and TC‐99m MIBI had an 87% and 89% sensitivity in detecting cervical lymph node involvement, respectively 44 . For indeterminate MRI findings, TC‐99m MIBI and 201 Tl SPECT can serve as an adjunctive alternative 43 …”

Section: Resultsmentioning

confidence: 99%

“…The consideration of SPECT imaging using either Tc-99m MIBI or201 Tl has been debated in the literature as alternatives or adjuncts to conventional endoscopy or imaging methods such as FDG-PET or MRI where conventional methods may fail due to post-radiation changes in the nasopharyngeal area. In this review, six studies were identified evaluating the specificity, sensitivity, and accuracy of Tc-99m MIBI or 201 Tl in surveillance of recurrent NPC 22,[40][41][42][43][44].…”

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confidence: 99%

See 2 more Smart Citations

Surveillance tools for detection of recurrent nasopharyngeal carcinoma: An evidence‐based review and recommendations

Thamboo¹,

Tran

et al. 2022

World j. otorhinolaryngol.-head neck surg.

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Objective: Nasopharyngeal carcinomas (NPC) are tumors arising from epithelium of the nasopharynx. The 5-year survival rate of primary NPC is 80% with significant risks of recurrence. The objective here is to provide an evidence-based systemic review of the diagnostic value of different modalities in detecting local, regional, and distal recurrent NPC, as well as the associated costs with these modalities.Methods: MEDLINE, EMBASE, and the Cochrane review database were queried.Two hundred and twenty-three abstracts were generated using the inclusion criteria: patients >18 years of age; histopathological reference standard; and modalities pertaining to imaging or microbiology.Results: Twenty-four manuscripts fulfilled the inclusion criteria and 5 surveillance tools identified: endoscopy, MR, FDG-PET, Tc-99m MIBI and 201 TI SPECT, and EBV DNA.Conclusions: For local surveillance, endoscopy is the gold standard recommendation, with increased efficacy if Narrow Band Imaging or contact endoscopy are utilized. MRI and FDG-PET is also recommended to help with local to distal spread; however, Tc-99m MIBI and 201 TI SPECT are options as well. EBV DNA is recommended as a cheap and accessible adjunct surveillance tool if an available as an option.

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Application of technetium-99m-sestamibi in differentiation of active from inactive pulmonary tuberculosis using a single photon emission computed tomography method

Ahmadihosseini

Sadeghi²,

Kakhki³

et al. 2008

Nuclear Medicine Communications

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Evaluation of Undifferentiated Carcinoma of Nasopharyngeal Type with Thallium‐201 and Technetium‐99m MIBI SPECT

Abstract: 201-Tl SPECT and Tc-99m MIBI SPECT are useful for detecting primary UCNT, residual/recurrent disease, and lymph node involvement. This use is particularly valuable after chemoradiotherapy when CT/MRI may be ambiguous.

Cited by 4 publications

References 12 publications

The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

The role of technetium Tc99m-tetrofosmin as head and neck tumor-seeking agent: a preliminary report

Surveillance tools for detection of recurrent nasopharyngeal carcinoma: An evidence‐based review and recommendations

Application of technetium-99m-sestamibi in differentiation of active from inactive pulmonary tuberculosis using a single photon emission computed tomography method

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