Evaluation of Urine Tumor-Associated Trypsin Inhibitor, CYFRA 21-1, and Urinary Bladder Cancer Antigen for Detection of High-Grade Bladder Carcinoma

Gkialas, Ioannis; Papadopoulos, Georgios; Iordanidou, Lydia; Stathouros, Georgios; Tzavara, Chara; Gregorakis, Alkiviadis; Lykourinas, M.

doi:10.1016/j.urology.2008.04.009

Cited by 28 publications

(20 citation statements)

References 20 publications

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“…In spite of this, increased urine concentrations of SPINK1 are significantly associated with adverse prognosis (61,63 ). In particular, SPINK1 has been shown to be a useful marker for highgrade bladder cancer (64,65 ), and serum SPINK1 has been shown to predict the response to chemotherapy and to be useful for monitoring of treatment (65 ).…”

Section: Bladder Cancermentioning

confidence: 99%

Emerging Roles of SPINK1 in Cancer

et al. 2016

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BACKGROUND Tumor-associated trypsin inhibitor (TATI) was originally isolated from the urine of a patient with ovarian cancer. It was later shown to be produced by many other tumors and several normal tissues. It had earlier been isolated from the pancreas and was hence called pancreatic secretory trypsin inhibitor (PSTI). It belongs to a family of protease inhibitors presently called serine peptidase inhibitor Kazal type (SPINK). In the SPINK family TATI/PSTI is SPINK1, which is the name used in this review. CONTENT In addition to being a protease inhibitor, SPINK1 also acts as an acute-phase reactant and a growth factor. Furthermore, it has been shown to modulate apoptosis. Overexpression of SPINK1 predicts an unfavorable outcome in several cancers and determination of SPINK1 in serum can be used to identify patients at increased risk of aggressive disease. Thus serum SPINK1 can be used as a prognostic tumor marker. Because SPINK1 acts as a growth factor and an inhibitor of apoptosis in some cancers, it has also been suggested that it can be a therapeutic target in cancer. However, because SPINK1 is the major physiological inhibitor of trypsin, inhibition of SPINK1 may increase the risk of pancreatitis. SUMMARY Taking into account the many functions of SPINK1, assessing the role of SPINK1 in cancer has several potentially important clinical applications ranging from a biomarker to a potential new target for cancer therapy.

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Section: Bladder Cancermentioning

confidence: 99%

Emerging Roles of SPINK1 in Cancer

et al. 2016

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“…In general, the development of cancer involves a series of changes in protein expression in the serum and cancerous tissues (Serrano et al, 2005;Gkialas et al, 2008;Varela et al, 2008;Hyrsl et al, 2009;Kim et al, 2011). However, the only way to monitor disease progression is to analyze bladder specimens.…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

Kaba

Pirinççi

Benli̇³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The obtained sensitivity agrees with the study of Hassanien, Nossier [29] that showed a sensitivity of CK-19 of 31%, however the specificity was higher (100%). Other studies have shown sensitivities ranging from 43% to 79% and specificities ranging from 68% to 88% for CK-19 mRNA and protein [30,31]. The high false positive rates of around 40% indicate that pathogenic bacteria may affect the reliability of considering CK-19 as a marker for bladder cancer detection.…”

Section: Discussionmentioning

confidence: 98%

Effect of pathogenic bacteria on reliability of CK-19, CK-20 and UPII as bladder cancer genetic markers: A molecular biology study

Shobaky

Abbas

Raouf

et al. 2015

Egyptian Journal of Basic and Applied Sciences

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a b s t r a c t Objectives: To evaluate the effect of the presence of pathogenic bacteria in urine on three bladder cancer genetic markers (Cytokeratin 19, Cytokeratin 20 and Uroplakin II mRNA), and to evaluate the reliability of each urine marker separately. Methods: Voided urine samples from 20 bladder cancer patients, 15 patients with urinary tract infection patients and 10 healthy volunteers were collected. Isolation and identification of bacteria was performed followed by determination of antimicrobial susceptibility of isolates. Evaluation of CK-19, CK-20 and UPII mRNA in urine by RT-PCR was carried out.Results: The most frequent organism isolated was Escherichia coli followed by Klebsiella pneumoniae. The overall sensitivity and specificity were 47.37% and 68.42%% for CK-19, 57.89% and 100% for CK-20 and 63.1% and 100%for UPII. Combined sensitivity and specificity of CK-20 and UPII biomarkers together was higher than that of each biomarker alone or even more than that of the three combined biomarkers. Conclusions: E. coli is the most predominant bacteria isolated from bladder cancer patients.Both CK-20 and UPII have different expression levels for both benign and malignant cases.Combined use of UPII and CK-20 may be a promising noninvasive tool for the detection of bladder cancer in urine for patients who have both symptoms of UTI and cancer.

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Evaluation of Urine Tumor-Associated Trypsin Inhibitor, CYFRA 21-1, and Urinary Bladder Cancer Antigen for Detection of High-Grade Bladder Carcinoma

Cited by 28 publications

References 20 publications

Emerging Roles of SPINK1 in Cancer

Emerging Roles of SPINK1 in Cancer

Haptoglobin Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

Effect of pathogenic bacteria on reliability of CK-19, CK-20 and UPII as bladder cancer genetic markers: A molecular biology study

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