Evaluation of Vitamin D Levels in Women with Carpal Tunnel Syndrome

Abstract

Background: For decades, the role of vitamin D was limited to the formation and maintenance of bone as well as homeostasis of calcium and phosphate. Vitamin D is a steroid molecule, mainly synthesized in the skin from 7 dehydro cholesterol by ultraviolet irradiation or obtained through the diet. The major circulating metabolite of vitamin D is 25(OH) Vitamin D (25(OH)D), with a halflife of 21-30 days. Serum concentration of 25(OH) D is the most reliable biochemical index of vitamin status. Aim: The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS) Patients and Methods: This study included 50 female patients with mild to moderate CTS and assessed their serum 25-hydroxyvitamin D levels. We included patients with a diagnosis of CTS based on both the clinical symptoms and positive neurophysiology. Controls (electrophysiological negative symptomatic patients) were evaluated 50 patients matched with sex and age clinically by rheumatologist. Results: the mean age of patients with CTS symptoms and control group were 49.2 ± 10.6 (range 21-54) and 49.7 ± 10.6 (range 20-55), respectively, with no significant difference between the two groups (p = 0.534). Patients with CTS symptoms had significantly lower 25(OH) D levels compared to controls. There's significance difference among the CTS patient regarding Boston Carpal Tunnel Questionnaire (BQ). Conclusion: a potential link between vitamin D status and the occurrence of CTS is suggested.

The effect of different doses of vitamin D on the prognosis of patients undergoing carpal tunnel syndrome surgery

“…[ 36 ] In their study on female patients with CTS, Okasha et al . [ 37 ] found that the level of Vitamin D in these patients was lower than normal. Similar results were also found by Gürsoy et al .…”