Surgical resection is the primary treatment modality for patients with head and neck neoplasms. Tissue defects resulting from the procedure cause disturbances in function and aesthetics. In addition, numerous changes in the stomatognathic system may occur in this group of patients, making prosthetic rehabilitation difficult. Methods to simplify production technology and to increase the precision of prosthetic replacements are constantly sought. Dynamically developing CAD/CAM technologies are also more and more frequently used in the treatment of postoperative patients. The use of computer-aided design and manufacturing enables the creation of precise restorations, shortens the rehabilitation time, facilitates archiving of data and improves communication between different departments. The ability to obtain data from magnetic resonance images (MRI), computed tomography (CT), 3D photogrammetry and intra-oral scanning (IS) enables accurate planning of resection procedures and designing prosthetic restorations; patients can use them immediately following the surgery to restore function, aesthetics and comfort of life. The development of CAD/CAM techniques and