Evaluation of workplace exposure to respirable crystalline silica in Italy

Scarselli, Alberto; Corfiati, Marisa; Marzio, Davide Di; Iavicoli, Sergio

doi:10.1179/2049396714y.0000000078

Cited by 18 publications

(11 citation statements)

References 23 publications

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“…The main limitations of the SIREP database are the inhomogeneous territorial coverage and the underrepresentation of some economical activities, as already underlined in previous studies (27,28). Data collection and reporting for the SIREP system is under the responsibility of the employer, and we observed that the number of exposure measurements differed by industrial sector and firm size.…”

Section: Discussionmentioning

confidence: 59%

Appraisal of levels and patterns of occupational exposure to 1,3-butadiene

Scarselli¹,

Corfiati²,

D³

et al. 2017

Scand J Work Environ Health

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Objectives 1,3-butadiene is classified as carcinogenic to human by inhalation and the association with leukemia has been observed in several epidemiological studies. The aim of this study was to evaluate data about occupational exposure levels to 1,3-butadiene in the Italian working force. Methods Airborne concentrations of 1,3-butadiene were extracted from the Italian database on occupational exposure to carcinogens in the period 1996-2015. Descriptive statistics were calculated for exposure-related variables. An analysis through linear mixed model was performed to determine factors influencing the exposure level. The probability of exceeding the exposure limit was predicted using a mixed-effects logistic model. Concurrent exposures with other occupational carcinogens were investigated using the two-step cluster analysis. Results The total number of exposure measurements selected was 23 885, with an overall arithmetic mean of 0.12 mg/m3. The economic sector with the highest number of measurements was manufacturing of chemicals (18 744). The most predictive variables of the exposure level resulted to be the occupational group and its interaction with the measurement year. The highest likelihood of exceeding the exposure limit was found in the manufacture of coke and refined petroleum products. Concurrent exposures were frequently detected, mainly with benzene, acrylonitrile and ethylene dichloride, and three main clusters were identified. Conclusions Exposure to 1,3-butadiene occurs in a wide variety of activity sectors and occupational groups. The use of several statistical analysis methods applied to occupational exposure databases can help to identify exposure situations at high risk for workers' health and better target preventive interventions and research projects.

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Section: Discussionmentioning

confidence: 59%

Appraisal of levels and patterns of occupational exposure to 1,3-butadiene

Scarselli¹,

Corfiati²,

D³

et al. 2017

Scand J Work Environ Health

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“…The International Agency for Research on Cancer (IARC) has classified crystalline silica as a known human carcinogen (9). The National Institute for Occupational Safety and Health (NIOSH) and the National Toxicology Program (NTP) also define crystalline silica as carcinogenic to humans (3,10).…”

Section: Introductionmentioning

confidence: 99%

Blood Oxidative Stress Levels in Workers Exposed to Respirable Crystalline Silica in the West of Iran

et al. 2019

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Background: Occupational exposure to crystalline silica is still an important health problem, especially in developing countries. Exposure to silica may be associated with the induction of toxic oxidative stress. Objectives: This study was conducted to assess oxidative stress biomarkers in workers exposed to respirable crystalline silica (RCS) in Hamadan city, the west of Iran. Methods: This descriptive-analytical study was conducted on two groups of exposed workers selected from four industries and unexposed office workers in 2017. The analysis of RCS in air samples was done by NIOSH method No. 7602. Malondialdehyde (MDA), total antioxidant capacity (TAC), and catalase (CAT) activity were measured in serum samples. Results: In this study, 48 healthy workers exposed to silica and 47 unexposed workers as controls were selected. The mean MDA levels (26.91 ± 14.26 nmol/mL) and CAT activity (10.83 ± 5.06 U/mL) were higher in the exposed group than in the unexposed group (P < 0.001). However, no statistically significant difference was observed in the TAC levels between the groups and no correlation was observed between exposure to RCS and oxidative stress biomarker levels in exposed subjects. Conclusions: Although there was a significant difference in the oxidative stress levels between the groups, according to other results of our study, it is not possible to claim that oxidative stress biomarkers are appropriate biological indices for silica exposure monitoring in occupational settings. Therefore, we still require a comprehensive study of other aspects of this research field.

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“…The presence and quantity of free silica in mines and the occupational exposure of miners to silica dust have been the subject of many studies. Many of these studies have reported that, in most mines, the total and respirable dust levels are higher than the standard exposure limit (Golbabaei et al, 2004, Scarselli et al, 2014, Hayumbu et al, 2008, Azari et al, 2009. A study by Koo et al (2000) on the exposure to crystalline silica dust showed that the concentration of crystalline silica in the core-making unit was 0.023 mg/m 3 , which is lower than the limit, but in other units (molding, cleaning, melting) it was higher than the standard limits specified by the National Institute for Occupational Safety and Health (NIOSH) and ACGIH (Koo et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Occupational Exposure to Silica Dust in Mining Workers in Eastern Iran

Golbabaei¹,

Gholami²,

Teimori-Boghsani³

et al. 2019

TOECOLJ

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Background and Objective: Silica dust is present in almost all mining operations and can cause various health problems such as silicosis in workers. The present study aimed to determine the total and respirable dust levels and the crystalline silica content of the soil in the breathing zone of workers in Iranian mines. Methods: This cross-sectional study was carried out in 2016-2017 on six Iranian silica mines. Dust sampling was performed according to the National Institute of Occupational Safety and Health (NIOSH) method No. 0600. The samples were collected from the respiratory zone of workers at 114 stations in different units of the mines. The silica content was measured using the standard NIOSH method No. 7601. The crystalline silica content in bulk samples collected from the soil was determined by using the X-Ray Diffraction (XRD) spectroscopy method. Results: The highest concentration of crystalline silica dust was 2.81±0.49 mg/m3 and was observed in the air of crushing unit of mine no. 6, and the lowest was 0.08±0.208 mg/m3 and was measured in the management/administration unit of mine no.1. The mean silica content in the solid surface of the mines was 91%. The total and respirable dust levels in all units of the mines except management/administration were higher than the permissible limit. The free silica content of all collected samples was substantially higher than the permissible limits, and in some cases, it was as much as 100 times above the standard level, which reflects the extremely high risk of working in these mines. Conclusion: Exposure of workers with crystalline silica dust in all units was higher than the standard recommended limits. It is imperative to adopt immediate measures based on technical, managerial, and personal protection solutions to reduce the exposure of workers to silica.

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Evaluation of workplace exposure to respirable crystalline silica in Italy

Cited by 18 publications

References 23 publications

Appraisal of levels and patterns of occupational exposure to 1,3-butadiene

Appraisal of levels and patterns of occupational exposure to 1,3-butadiene

Blood Oxidative Stress Levels in Workers Exposed to Respirable Crystalline Silica in the West of Iran

Evaluation of Occupational Exposure to Silica Dust in Mining Workers in Eastern Iran

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