Evaluation of Wound healing and Antiinflammatory Activities of New Poly-herbal Formulations

Abstract

Present investigation evaluated the impact of poly-herbal formulations comprising extracts of Zingiberofficinale, Curcuma longa, Aloe barbadensis, Citrus aurantium, Emblica officinalis and castor oilon wound healing activity using excision wound model and antiinflammatory activity using formalininduced pawedema method. Ointments containing 2, 4 and 6 % w/w of extracts were made and used in wound healing action and all the formulations significantly (p<0.01) reduced the wound area. Ointment of 6 % w/w has shown better results than 2 and 4 % w/w. These results were compared to that of the standard framycetin. Poly-herbal formulation-1, poly-herbal formulation-2 and poly-herbal formulation-3 were prepared and used at doses of 100, 300 and 500 mg/kg to determine antiinflammatory activity. All poly-herbal formulations significantly (p<0.01) inhibited formalin-induced rat paw edema. Poly-herbal formulation-3 displayed greater inhibition than poly-herbal formulations 1 and 2. These results were comparable to that of the standard diclofenac. Present work and previous studies on poly-herbal formulations corroborates that these are safer and effective in treating inflammation and wounds.

Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives

“… Acacia nilotica (Stem bark) , Withania somnifera (Roots) , Juniperus communis (fruits) , Tinospora cordifolia (stem) , Aspargus recemosus, (Gokshuara roots) Tribulus terrestris, (fruits) , Argyeria nervosa (roots) , Pluchea lanceolata (roots & leaves) , Anethum sowa (fruit) , Hidichium spicatum (rhizome) , Trachyspermum ammi (fruits) , Zingibero fficinale, shuddha (Rhizome) , Commiphora mukul and ghee (exudates) Trayodashangguggulu In-vito studies In-vito anti-inflammatory activities by the virtue of anti-lipoxygenase and anti-proteinase activities [ 43 ] 38. Zingiber officinale, Curcuma longa, Aloe barbadensis, Citrus aurantium, Emblica officinalis and castor oil – Rats Anti-inflammatory activity accelerated excision wound healing process [ 44 ] 39. Balsamodendron mukul, Colchicum luteum, Withania somnifera, Asphaltum, Strychnos nuxvomica, Cyperuss cariosus, Pluchea lanceolata, Vitex negundo, Boerhaavia diffusa, Trigonella foenumgraecum, Operculina turpethum, Asparagus racemosus, Cissus quadrangularis, Curcuma longa, Zingiber officinale, Picrorhiza kurroa, Godantibhasma, Muktashuktibhasma, Yograg guggul (Classical product) , Trachyspermum ammi, Corallium rubrum, Vitex nigundo, Dasmool (Classical product) , Tinospora cordifolia) and Gum acacia PeedantakVati Male Wistar rats Anti-inflammatory and analgesic property by inhibiting pro inflammatory cytokinin viz .…”

“…The active compounds present in the polyherbal formulations, such as flavonoids and phenols are often useful in suppressing the production of inflammatory cytokines and thereby blocking the inflammatory transduction cascade [ 13 ]. These polyherbal formulations are reported to have natural anti-inflammatory activity with the lowest degree of side effects [ 44 , 48 , 52 ]. The literature review indicates various in-vivo studies depicting the potential of polyherbal formulations to suppress pro-inflammatory cytokinins and interleukins, thereby aiding in the wound-healing.…”

Evaluation of Newer Poly Herbal Formulations for Wound Healing and Anti-Inflammatory Activity

“…Topically applied herbal medicines have established considerable attention because of their extensive use and well-defined benefits / risk ratio 1 . Topical application of cream and ointment at damaged tissue will enhance the penetration of dosage form and rapid release of drug directly into the site of action 2 . The concept of poly herbalism has mentioned in "Sarangdhar Samhitha".…”