Evaluation of Wound Healing Potential of Some Indian Herbal Extracts and it’s Formulation in Acne Vulgaris

Abstract

Objective: Butea monosperma, Barleria prionitis, Casuarina equisetifolia, Dalbergia sissoo, and Lagenaria siceraria are reported to possess anti-acne, anti-infl ammatory, anti-ulcer, and wound healing activity. The present work is aimed at evaluating the wound healing potential of these plant materials in acne vulgaris. Methodology: Individual gel formulations containing extracts of the above mentioned drugs and their polyherbal gels were evaluated by excision and incision wound model (in vivo) in Sprague Dawley rats. Results: The individual gel formulations showed signifi cant reduction in wound size when compared with the untreated group. The rates of wound closure after the application of the gels were compared with the untreated wounds. The polyherbal formulation containing all the extracts was found to be more benefi cial when compared to remaining treated groups. Healing under scab and formation of normal epithelial cells were better than other individual formulations. As well as vascular changes, cellular infi ltration, and necrosis were found less. Conclusion:From the results, it may be concluded that the plants are endowed with signifi cant wound healing activity, thereby justifying its traditional medicinal use in acne vulgaris as a separate entity and in combination. Chemical components such as tannins, fl avonoids, saponins, and alkaloids present in the extracts can be responsible for the foresaid activity.

Preclinical evidence of polyherbal formulations on wound healing: A systematic review on research trends and perspectives

“…and Ghrita (Ghee) GC02: Myristica fragrans Houtt., Melia azadarch Linn ., Trichosanthes cucumerina Linn ., Picrorhiza kurroa, Berberis aristata DC ., Curcuma longa Linn ., Hemidesmus indicus R ., Rubia cordifolia Linn ., Terminalia chebula, Vetiveria zizanioides (L.), Madhuca longifolia and Pongamia glabra GC01, GC02 Rats synergistic/potentiative action was observed for individual herb [ 27 ] 22. Butea monosperma, Barleria prionitis, Casuarina equisetifolia, Dalbergia sissoo, and Lagenaria siceraria – Sprague Dawley rats Excision and incision wound model faster wound size reduction and wound closure rates [ 28 ] 23. Ixora coccinea (flowers) , Psidium guajava (roots), Neolamarckia cadamba (leaves).…”

“…Data from the earlier studies depicts various experimental wound models such excision model [ 9 , 10 , 12 , 15 , 21 , 26 , 28 ] incision model [ 10 , 12 , 21 ], burn wound model [ 7 , 12 , 20 , 21 ] and dead space wound model [ 10 , 12 ] has been used for evaluating various wound healing potentials of the polyherbal formulations under study. The excision model was prevalent in most of the studies.…”

Herbs used in treatment of mouth ulcer- a review

“…In order to facilitate the creation of a good environment for natural healing, herbal medicines in wound management include disinfection, debridement, surgical intervention, and maintaining a moist environment. Hence it is evident that herbal medicines are playing a major role in treatment strategies which are adopted globally [2].…”