1998
DOI: 10.1007/978-1-4899-0089-0_24
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Evaluation of Xenoestrogenic Effects in Fish on Different Organization Levels

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Cited by 4 publications
(5 citation statements)
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“…The rainbow trout primary hepatocyte vitellogenin or zona radiata protein assay includes these circumstances and therefore often is considered to be the most valid test to characterize the estrogenicity of a substance in vitro. However, high intra‐ [38] and interassay variability of the inducibility of vitellogenin or zona radiata proteins in hepatocytes is observed. Because immature female, immature mixed sex, or adult male rainbow trout were used for these studies, seasonal‐, age‐, and sex‐specific differences that result in different steroid levels and ER abundance may explain some of this variability.…”
Section: Discussionmentioning
confidence: 99%
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“…The rainbow trout primary hepatocyte vitellogenin or zona radiata protein assay includes these circumstances and therefore often is considered to be the most valid test to characterize the estrogenicity of a substance in vitro. However, high intra‐ [38] and interassay variability of the inducibility of vitellogenin or zona radiata proteins in hepatocytes is observed. Because immature female, immature mixed sex, or adult male rainbow trout were used for these studies, seasonal‐, age‐, and sex‐specific differences that result in different steroid levels and ER abundance may explain some of this variability.…”
Section: Discussionmentioning
confidence: 99%
“…Because immature female, immature mixed sex, or adult male rainbow trout were used for these studies, seasonal‐, age‐, and sex‐specific differences that result in different steroid levels and ER abundance may explain some of this variability. The concentration for half‐maximal vitellogenin induction for E 2 ranges from 1.8 nM [9] to 500 nM [39], whereas intermediate values of 46 nM [38] and 100 nM [40,41] have been measured.…”
Section: Discussionmentioning
confidence: 99%
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“…Because immature female, immature mixed sex, or adult male rainbow trout were used for these studies, seasonal-, age-, and sex-specific differences that result in different steroid levels and ER abundance may explain some of this variability. The concentration for half-maximal vitellogenin induction for E 2 ranges from 1.8 nM [9] to 500 nM [39], whereas intermediate values of 46 nM [38] and 100 nM [40,41] have been measured.…”
Section: Comparison With Primary Fish Hepatocytesmentioning
confidence: 98%
“…Only very few studies with primary hepatocytes present complete dose-response curves of environmental estrogens such as NP, OP, and Bis A. When testing these compounds, vitellogenin induction occurred between concentrations of 10 and 100 M [38]. In contrast, White et al [8] detected OPand NP-induced vitellogenin expression at 0.1 M and 1 M, respectively.…”
Section: Comparison With Primary Fish Hepatocytesmentioning
confidence: 99%