Evaluation of YashtimadhuKalpa formulation as Neuro-nutrient for Learning and Memory improvement in experimental animals

Abstract

The unique functions of the brain are learning, memory, and ability to find objects, recollecting them, and cognition. The foremost intention of the study is to appraise the memory-enhancing potential of “YashtimadhuKalpa” using Wistar rats. The formulation YashtimadhuKalpawas prepared using various ingredients and was evaluated for memory-enhancing activity by using Morris water test and elevated plus maze apparatus for the parameter like transfer latency. The formulation - YashtimadhuKalpa (75, 150, and 300 mg/kg, p.o.) used for consecutive four weeks significantly reduced TL at the 29th day as correlated to the respective control sets, show enhancement in memory. All doses of formulation notably decreased EL of rats when checked for Day 1, day 15 and on day 30th as related to the control and showed noteworthy enhancement of learning and memory. Among all the doses, the higher dose at 300 mg/kg, p.o. Presents a highly important effect on TL as related to the vehicle-treated control set. The decline of transfer latency dose-dependently proved its potency against Neurodegeneration and confirmed its nootropic activity.