Evaluation of yeast hydrolysate as a substitute to dietary fish meal of| juvenile Jian carp (
            <i>Cyprinus carpio</i>
            var. Jian): Protein synthesis via TOR pathway

Yuan, Xiangyang; Wang, Can-Li; Liu, Wenbin; Jiang, Guang‐Zhen; Dai, Yong‐Jun

doi:10.1111/anu.13322

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…Induction of protein synthesis through the TOR pathway has been previously demonstrated in juvenile Jian carp ( C. carpio var. Jian) in response to fish meal substitution with yeast hydrolysate [ 77 ]. In contrast, dietary supplementation of cottonseed meal protein hydrolysate at high levels repressed protein synthesis due to inhibition of the TOR signaling pathway via activation of AMPK [ 78 ].…”

Section: Discussionmentioning

confidence: 99%

The Probiotic Phaeobacter inhibens Provokes Hypertrophic Growth via Activation of the IGF-1/Akt Pathway during the Process of Metamorphosis of Greater Amberjack (Seriola dumerili, Risso 1810)

Panteli,

Feidantsis,

Demertzioglou

et al. 2023

Animals

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Metamorphosis entails hormonally regulated morphological and physiological changes requiring high energy levels. Probiotics as feed supplements generate ameliorative effects on host nutrient digestion and absorption. Thereby, the aim of the present research was to investigate the impact of the probiotic Phaeobacter inhibens as a water additive on cellular signaling pathways in the metamorphosis of greater amberjack (Seriola dumerili). Activation of insulin-like growth factor type 1 receptor (IGF-1R), protein kinase B (Akt), mitogen-activated protein kinases (MAPKs) and AMP-activated protein kinase (AMPK), induction of heat shock proteins (Hsps), and programmed cell death were assessed through SDS-Page/immunoblot analysis, while energy metabolism was determined through enzymatic activities. According to the results, greater amberjack reared in P. inhibens-enriched water entered the metamorphic phase with greater body length, while protein synthesis was triggered to facilitate the hypertrophic growth as indicated by IGF-1/Akt activation and AMPK inhibition. Contrarily, MAPKs levels were reduced, whereas variations in Hsps response were evident in the probiotic treatment. Apoptosis and autophagy were mobilized potentially for the structural remodeling processes. Furthermore, the elevated enzymatic activities of intermediary metabolism highlighted the excess energy demands of metamorphosis. Collectively, the present findings demonstrate that P. inhibens may reinforce nutrient utilization, thus leading greater amberjack to an advanced growth and developmental state.

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Section: Discussionmentioning

confidence: 99%