Evaluation Serum levels of Leptin,CRP and Lipid profile in Hypothyroid Women in Kirkuk city/Iraq

Abstract

Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores with a primary function in the control of lipid reserves,this study aimed to evaluate the influence of hypothyroidisim on serum levels of Leptin,CRP and lipid profile,blood sample was collected from 75 women age ranged between (15-49) years 65 of the them had hypothyroidisim while 10 of the samples were healthy control, The results showed no significant diffirence in serum Leptin (p =0.1),while there was significant high concentration of serum leptin in obeses hypothyroid women in compared to non obeses hypothyroid women Serum Cholesterol ,Triglyceride , VLDL in addition to serum LDL were significantly higher in patient compared to control group,the Serum CRP levels were significantly Higher in hypothyroid patient compared to the control, circulating thyroid hormones do not appear to play a significant effect on Leptin Levels in patients with hypothyroidisim While it Causes Dyslipidemia,with a significant increase in the serum levels of CRP as an inflamantory marker linked between hypothyroidism and risk factors of cardiovascular events.

Bone and thyroid nexus in thyroid disease patients

“…Table (2) shows the correlation between obesity and hypothyroidism. The research conducted by HASSAN and ABBAS (2022) revealed a negative correlation between T 3 and T 4 , but a favorable link with TSH levels and body weight and BMI [13] . Verma et al (2008) found in another study that 44% of patients with hypothyroidism were obese [14] .…”