Evaluations of hydroxyapatite and bioactive glass in the repair of critical size bone defects in rat calvaria

Souza, Eduardo Quintão Manhanini; Klaus, Aline Evelin Costa; Santos, Bianca Fernanda Espósito; Costa, Manuella Carvalho da; Ervolino, Edílson; Lima, Daniela Coêlho de; Fernandes, Leandro Araújo

doi:10.1016/j.jobcr.2020.07.014

Cited by 12 publications

(11 citation statements)

References 36 publications

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“…Bioactive glass has many advantages such as its cohesiveness and graft retention characteristics, lack of immune responses and infection transmission, simple manipulation during surgery, and minimal susceptibility to infection because of its hydrophilic property that allows antibiotic penetration within the graft [ 21 ]. Bioactive glass has an osteoconductive property through binding by chemical adhesion with the newly formed bone [ 22 ]. This occurs as a result of tissue fluids corroding the glass surface, stimulating a layer of calcium rich in phosphorus and a sublayer of silica to attach closely to the bony apatite crystals.…”

Section: Discussionmentioning

confidence: 99%

“…This occurs as a result of tissue fluids corroding the glass surface, stimulating a layer of calcium rich in phosphorus and a sublayer of silica to attach closely to the bony apatite crystals. Studies have shown encouraging outcomes with bioactive glass in periodontal problems and maxillary sinus bone augmentation due to these features [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

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Autogenous Bone and Bioactive Glass around Implants Placed Simultaneously with Ridge Splitting for the Treatment of Horizontal Bony Defects: A Randomised Clinical Trial

Elamrousy

Osama

Issa

2021

International Journal of Dentistry

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Objective. To compare using autogenous bone with or without bioactive glass in ridge splitting of horizontal bone defects combined with simultaneous implant placement. Materials and Methods. In control group, bone expansion was performed and autogenous bone was used to augment the intercortical bone defect. In study group, autogenous bone was mixed with bioactive glass (1 : 1 in volume). In both groups, the implants were inserted simultaneously with ridge splitting. Six months following implant insertion, bone width and height were evaluated. Statistical analysis utilizing paired Student’s t-test was used for comparing results within the same group, whereas independent samples t-test was used for intergroup variables comparison. Results. The mean bone width and labial and mesiodistal crestal bone height values were increased significantly in both groups from baseline to 6 months postoperatively. Comparing the two groups showed nonstatistical significant difference regarding the labial crestal bone loss, while the ridge width gain values were significantly higher in the study group than in the control group. The mesiodistal bone loss was significantly higher in control group than in study group. Conclusion. Autogenous bone was mixed with bioactive glass (1 : 1 in volume) to fill intercortical defect created after ridge splitting to decrease peri-implant bone resorption associated with autogenous bone alone. This trial is registered with clinical trial registration: NCT04814160.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Autogenous Bone and Bioactive Glass around Implants Placed Simultaneously with Ridge Splitting for the Treatment of Horizontal Bony Defects: A Randomised Clinical Trial

Elamrousy

Osama

Issa

2021

International Journal of Dentistry

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“…The in vivo bioactivity of HAp has been improved by substitution with ions, such as Zn, 77 silicon, 78 strontium, 79 and lithium 80 . Some studies have indicated that HAp can effectively substitute autologous grafts 81,82 . The sources of HAp could be biological or synthetic.…”

Section: Classificationmentioning

confidence: 99%

“…80 Some studies have indicated that HAp can effectively substitute autologous grafts. 81,82 The sources of HAp could be biological or synthetic. Animal sources of HAp have been discussed under xenografts.…”

Section: Ceramicsmentioning

confidence: 99%

A novel classification of bone graft materials

2022

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Over the past few decades, the field of biomaterials concerning bone tissue engineering has gained a significant amount of interest. This has led to new biomaterials to be used as bone substitute materials. Despite the rapid increase in the types and forms of bone substitutes, a comprehensive classification encompassing all types of bone graft materials that have so far been developed and evaluated is lacking. Therefore, this review aims to integrate and bring together the published data on bone substitutes within the last 5 years and produce a novel classification that would provide bone material researchers with a better understanding of what materials have so far been used and evaluated and the areas, where research is lacking and deserves more attention. The literature available in all major databases was obtained and filtered using an elimination criterion to extract all the articles related to studies that tested bone substitute materials in nonclinical and clinical trials over the last 5 years. The review article would provide bone material researchers with an insight into the materials that have been evaluated for bone tissue engineering applications and identify future perspectives for bone graft material research.

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“…In recent years, nano-HA and micro-HA have been widely used as drug delivery carriers because their large specific surface area and surface charge enable them to load drugs; ,, especially, these nanomedicines with prolonged drug circulation and reduced drug toxicity are considered a superior treatment option for cancer. , Although HA is too brittle to maintain bone strength, its good biocompatibility and drug carrier ability make it significant to composite with other polymers to achieve good mechanical properties, and the composition and structure of synthetic HA are very similar to those of the natural bone mineral. HA is widely used as a bone substitute and presents excellent bone repair capacity; − in addition, HA has been shown to possess anticancer effects . HA integrates the triple functions of anticancer, promotion of osteogenesis, and loading drugs; therefore, HA loaded with anticancer drugs may be an ideal choice for preventing tumor recurrence and promoting bone regeneration after osteosarcoma resection.…”

Section: Introductionmentioning

confidence: 99%

Loading and Releasing Behavior of Selenium and Doxorubicin Hydrochloride in Hydroxyapatite with Different Morphologies

et al. 2021

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Doxorubicin (Dox)-loaded or selenium-substituted hydroxyapatite (HA) has been developed to achieve anti-osteosarcoma or bone regeneration in a number of studies. However, currently, there is a lack of studies on the combination of Dox and selenium loading in/on HA and comparative research studies on which form and size of HA are more suitable for drug loading and release in the treatment osteogenesis after osteosarcoma resection. Herein, selenium-doped rod-shaped nano-HA (n-HA) and spherical mesoporous HA (m-HA) were successfully prepared. The doping efficiency of selenium and the Dox loading capacity of selenium-doped HA with different morphologies were studied. The release kinetics of Dox and the selenium element in phosphate-buffered saline with different pH values was also comparatively investigated. The drug loading results showed that n-HA exhibited 3 times higher selenium doping amount than m-HA, and the Dox entrapment efficiency of selenium-doped n-HA (0.1Se-n-HA) presented 20% higher than that of seleniumdoped m-HA (0.1Se-m-HA). The Dox release behaviors of HA in two different morphologies showed similar release kinetics, with almost the same Dox releasing ratio but slightly more Dox releasing amount in selenium-doped HA than in HA without selenium. The selenium release from selenium-doped n-HA-D (0.1Se-n-HA-D) particles was 2 times as much as that of selenium-doped m-HA-D (0.1Se-m-HA) particles. Our study indicated that n-HA loaded with Dox and selenium may be a promising drug delivery strategy for inhibition of osteosarcoma recurrence and promoting osteogenesis simultaneously.

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Evaluations of hydroxyapatite and bioactive glass in the repair of critical size bone defects in rat calvaria

Cited by 12 publications

References 36 publications

Autogenous Bone and Bioactive Glass around Implants Placed Simultaneously with Ridge Splitting for the Treatment of Horizontal Bony Defects: A Randomised Clinical Trial

Autogenous Bone and Bioactive Glass around Implants Placed Simultaneously with Ridge Splitting for the Treatment of Horizontal Bony Defects: A Randomised Clinical Trial

A novel classification of bone graft materials

Loading and Releasing Behavior of Selenium and Doxorubicin Hydrochloride in Hydroxyapatite with Different Morphologies

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