This work provides, at lower order, general analytical solutions for the orbital separation, merging time, and orbital frequency of binary systems emitting gravitational waves while being submitted to mass variations. Specific features, depending on the exponent of the mass derivative, are investigated in details. Two phenomenologically interesting cases are explicitly considered : i) binaries formed by two light primordial black holes submitted to Hawking evaporation and ii) bodies driven by a Bondi accretion of phantom dark energy. It is shown that three different regimes arise, including an intricate non-monotonic behaviour of the system. We study subtle imprints that could be associated with those phenomena. A careful analysis of the conditions of validity of the different hypotheses performed is finally carried out.