Evaporation based micro pump integrated into a scanning force microscope probe

Heuck, F.; Hug, Thomas; Akiyama, T.; Frederix, P. L. T. M.; Engel, Andréas; Meister, André; Heinzelmann, H.; Rooij, N. F. de; Staufer, U.

doi:10.1016/j.mee.2007.12.047

Cited by 15 publications

(11 citation statements)

References 7 publications

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“…Thus, they are required to be miniaturized and integrated with several fluidic components without using an external macro-scale power source or controller. To meet these demands, various types of non-mechanical micropumps utilizing capillary force, surface tension, evaporation, vacuum-driven, and paper-based devices, have been developed410111213. However, most of them still have technological limitations of single-use, short-term operation, or needs of additional integration with a dedicated flow controller.…”

mentioning

confidence: 99%

“…This is a multiple-use pumping system applicable to any hydrophilic liquid including therapeutic agents. Using this system, we can resolve the technical limitations of single-use or short-term use encountered in capillary-based or paper-based micropumps410111213. The LIM can also cope with the thermally sensitive flow rate of conventional evaporative micropumps, whose flow rate is passively determined on the basis of temperature, by using thermo-sensitive hydrogels, poly( N -isopropylacrylamide) (PNIPAAm) (Table 1)1415161718192021222324.…”

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confidence: 99%

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Compact and Thermosensitive Nature-inspired Micropump

Kim

Lee

2016

Sci Rep

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Liquid transportation without employing a bulky power source, often observed in nature, has been an essential prerequisite for smart applications of microfluidic devices. In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesophyll-inspired agarose cryogel (MAC) is proposed. The LIM provides a durable flow rate of 30 μl/h · cm2 for more than 30 h at room temperature without external mechanical power source. By adapting a thermo-responsive polymer, the LIM can smartly adjust the delivery rate of a therapeutic liquid in response to temperature changes. In addition, as the LIM is compact, portable, and easily integrated into any liquid, it might be utilized as an essential component in advanced hand-held drug delivery devices.

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confidence: 99%

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confidence: 99%

Compact and Thermosensitive Nature-inspired Micropump

Kim

Lee

2016

Sci Rep

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“…For a controlled flow of liquid from the reservoir to the tip, various pumping techniques were developed. In this section, we review the pumping techniques based on liquid evaporation [95], thermal energy [96], electro-osmosis [97], pressure [25] and syringe pump [69]. Pumping becomes even more significant for dispensing in liquid environment due to the absence of capillary forces.…”

Section: Handling Of Fluids Within the Probesmentioning

confidence: 99%

“…Only the geometry of the capillary outlet area needs to be increased to enhance the evaporation thus inducing pumping. The working principle of an evaporation induced pump integrated in a SIP is exemplarily explained in Figure 4a [95]. A water-based solution was filled into the inlet (reservoir).…”

Section: Evaporation Pumpmentioning

confidence: 99%

Scanning Probe Microscope-Based Fluid Dispensing

et al. 2014

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Advances in micro and nano fabrication technologies have enabled fabrication of smaller and more sensitive devices for applications not only in solid-state physics but also in medicine and biology. The demand for devices that can precisely transport material, specifically fluids are continuously increasing. Therefore, integration of various technologies with numerous functionalities in one single device is important. Scanning probe microscope (SPM) is one such device that has evolved from atomic force microscope for imaging to a variety of microscopes by integrating different physical and chemical mechanisms. In this article, we review a particular class of SPM devices that are suited for fluid dispensing. We review their fabrication methods, fluid-pumping mechanisms, real-time monitoring of dispensing, physics of dispensing, and droplet characterization. Some of the examples where these probes have already been applied are also described. Finally, we conclude with an outlook and future scope for these devices where femtolitre or smaller volumes of liquid handling are needed.

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“…Evaporation can be put to good use by employing it as a microfluidic pumping (Effenhauser et al 2002;Goedecke et al 2002;Heuck et al 2008;Namasivayam et al 2003;Zimmermann et al 2005;Xu et al 2008) or sample concentration (Timmer et al 2003;Walker and Beebe 2002) mechanism. However, evaporation is also seen as a problematic issue for most applications, especially for temperature-controlled small-scale bioreaction systems.…”

Section: Introductionmentioning

confidence: 99%

Decreasing microfluidic evaporation loss using the HMDL method: open systems for nucleic acid amplification and analysis

Zhang

Xing

2009

Microfluid Nanofluid

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Evaporation is of great importance when dealing with microfluidic devices with open air/liquid interfaces due to the large surface-to-volume ratio. For devices utilizing a thermal reaction (TR) reservoir to perform a series of biological and chemical reactions, excessive heatinduced microfluidic evaporation can quickly lead to reaction reservoir dry out and failure of the overall device. In this study, we present a simple, novel method to decrease heat-induced fluid evaporation within microfluidic systems, which is termed as heat-mediated diffusion-limited (HMDL) method. This method does not need complicated thermal isolation to reduce the interfacial temperature, or external pure water to be added continuously to the TR chamber to compensate for evaporation loss. The principle of the HMDL method is to make use of the evaporated reaction content to increase the vapor concentration in the diffusion channel. The experimental results have shown that the relative evaporation loss (V loss /V ini ) based on the HMDL method is not only dependent on the HMDL and TR region's temperatures (T HMDL and T TR ), but also on the HMDL and TR's channel geometries. Using the U-shaped uniform channel with a diameter of 200 lm, the V loss /V ini within 60 min is low to 5% (T HMDL = 105°C, T TR = 95°C). The HMDL method can be used to design open microfluidic systems for nucleic acid amplification and analysis such as isothermal amplification and PCR thermocycling amplification, and a PCR process has been demonstrated by amplifying a 135-bp fragment from Listeria monocytogenes genomic DNA.

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Evaporation based micro pump integrated into a scanning force microscope probe

Cited by 15 publications

References 7 publications

Compact and Thermosensitive Nature-inspired Micropump

Compact and Thermosensitive Nature-inspired Micropump

Scanning Probe Microscope-Based Fluid Dispensing

Decreasing microfluidic evaporation loss using the HMDL method: open systems for nucleic acid amplification and analysis

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