Encyclopedia of Analytical Chemistry 2012
DOI: 10.1002/9780470027318.a9238
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Evaporative‐Based Detectors as Global Response Instruments

Abstract: Evaporative‐based detectors are a new generation of instruments, which provide a universal response for a wide variety of compounds or their families whose determination by other conventional detection systems is limited by different reasons. Both evaporative light scattering detector (ELSD) and corona‐charged aerosol detector (C‐CAD) have been recognized as global response detectors in liquid and supercritical chromatographies. Their advantage over optical or electrochemical detectors is that they do not requ… Show more

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“…Ion mobility spectrometry (IMS) is becoming an indispensable tool for the analysis of ions in the gas phase, with applications ranging from simple analytical systems used in security applications [1][2][3][4] to the analysis of complex biological samples in omics research in conjunction with mass spectrometry. [5][6][7] IMS has also shown promise as an attractive alternative to traditional separation techniques (e.g., liquid chromatography). 8 Furthermore, IMS-based separations can provide additional insight into the characterization of a given analyte based on the relationship between an ion's mobility (the basis on which ions are separated in the gas phase) and its rotationally averaged ion-neutral collisional cross section, established by the Mason-Schamp relationship.…”
mentioning
confidence: 99%
“…Ion mobility spectrometry (IMS) is becoming an indispensable tool for the analysis of ions in the gas phase, with applications ranging from simple analytical systems used in security applications [1][2][3][4] to the analysis of complex biological samples in omics research in conjunction with mass spectrometry. [5][6][7] IMS has also shown promise as an attractive alternative to traditional separation techniques (e.g., liquid chromatography). 8 Furthermore, IMS-based separations can provide additional insight into the characterization of a given analyte based on the relationship between an ion's mobility (the basis on which ions are separated in the gas phase) and its rotationally averaged ion-neutral collisional cross section, established by the Mason-Schamp relationship.…”
mentioning
confidence: 99%