Evening Primrose Oil in Patients With Rheumatoid Arthritis and Side-Effects of Non-Steroidal Anti-Inflammatory Drugs

Brzeski, M; Madhok, Rajan; Capell, Hilary A.

doi:10.1093/rheumatology/30.5.370

Cited by 82 publications

(51 citation statements)

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“…In some of these studies improvements were also reported in the group treated with olive oil (46,47,60). The beneficial effect observed in these studies, may be attributed to the monounsaturated fatty acid (MUFA) oleic acid (OA; 18:1n-9), which constitutes a large proportion of the fatty acids present in olive oil.…”

Section: Dietary Supplementationmentioning

confidence: 93%

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Mediterranean dietary intervention study of patients with rheumatoid arthritis

Hagfors

2005

Scandinavian Journal of Nutrition

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Case control studies have shown that a high consumption of fish, olive oil, and cooked vegetables is associated with a decreased risk of developing rheumatoid arthritis (RA). These foods have a central position in the traditional Cretan Mediterranean diet, and it has been suggested that dietary factors contribute to the low prevalence of RA in Mediterranean countries. The overall aim of this thesis was to examine whether a modified Cretan Mediterranean diet can reduce signs and symptoms of RA. This was investigated in a three-month dietary intervention trial in which 51 patients with well controlled, although active RA of at least two years duration took part. A further aim was to study the compliance with the experimental and control diets used in the study, and to validate the diet history interview method used to assess the dietary intake. The validation was carried out by means of biological markers of dietary intake.From baseline to the end of the study the group that had adopted the Cretan Mediterranean diet (MD group; n=26) obtained a reduction in disease activity, improved physical function, and improved vitality, while no changes was seen in the control diet group (CD group; n=25).According to the dietary assessments, the intake frequencies of antioxidant-rich food items increased in the MD group. This group also had a significantly higher intake of vitamin E, vitamin C and selenium compared to the CD group. Despite the reported increase in the consumption frequencies of antioxidant-rich foods, the plasma levels of carotenoids, vitamin C, lipid adjusted tocopherols, uric acid and urine malondialdehyde, a marker of oxidative stress, were unchanged at the end of the study. The plasma levels of retinol, vitamin C and uric acid were, however, correlated to indices of disease activity. Changes in the reported consumption of food groups with relevance to the fat intake were also observed in the MD group, including an increased intake of fish, shellfish and poultry, and a decreased intake of meat and high fat dairy products. As a result, the total fat intake was lower in the MD group compared to the CD group. Furthermore, in the MD group a slightly higher percentage of the energy intake was derived from polyunsaturated fatty acids and a lower percentage from saturated fatty acids. This group also had a lower ratio of n-6:n-3 fatty acids. A corresponding change in the relation between n-6 and n-3 fatty acids was also observed in s-phospholipids.The validation of the diet history interview method showed that the diet history interview could capture the dietary intake fairly well. The validity of the reported dietary intake did not differ between the MD and the CD group, which indicates that the dietary assessment was not biased by the dietary intervention.

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Section: Dietary Supplementationmentioning

confidence: 93%

“…A few studies indicate that supplementation with γ-linolenic acid (GLA; 18:3n-6) can lead to clinical improvement in RA patients (60)(61)(62)(63). Like n-3 fatty acids, an increased intake of GLA seems to alter the profile of eicosanoids in a favourable manner.…”

Section: Dietary Supplementationmentioning

confidence: 99%

Mediterranean dietary intervention study of patients with rheumatoid arthritis

Hagfors

2005

Scandinavian Journal of Nutrition

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“…Jantti et al [38] administered EPO (GLA dose not given) or olive oil in a double-blind randomized study to RA patients for 12 weeks and noted no difference in clinical improvement. Similarly, Brzeski et al [39] found no advantage using EPO (560 mg GLA/day for 6 months) vs. olive oil to treat RA patients. Pullman-Mooar et al [40] fed 1,125 mg of GLA/day in the form of BO for 12 weeks to 7 RA patients and 4 healthy controls.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Potential of Evening Primrose, Borage, Black Currant, and Fungal Oils in Human Health

Barre¹

2001

Ann Nutr Metab

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“…Evening primrose oil has a high concentration of polyunsaturated fatty acids, in particular ␥ -linolenic acid (18: 3n-6), and has been used for more than 30 years as a dietary supplement [Hudson, 1984]. The beneficial effects of polyunsaturated fatty acids have been reported for various ailments such as rheumatic and arthritic conditions, atopic dermatitis, premenstrual and postmenopausal syndromes, and diabetic neuropathy [Brzeski et al, 1991;Berth-Jones and Graham-Brown, 1993;Cerin et al, 1993;Belch and Hill, 2000;Barre, 2001]. In addition, the mechanisms related to their actions have been studied in animal models [Engler, 1993;Dines et al, 1996] as well as humans [Ziboh and Chapkin, 1987;Ziboh et al, 2000].…”

Section: Inhibitory Effects Ofmentioning

confidence: 99%

Inhibitory Effects of Oenothera biennis (Evening Primrose) Seed Extract on Streptococcus mutans and S. mutans-Induced Dental Caries in Rats

Matsumoto‐Nakano¹,

Nagayama²,

Kitagori³

et al. 2011

Caries Res

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Background: Oenothera biennis (evening primrose) seed extract (OBSE) is known to contain polyphenols, which may possess antioxidant activities. Polyphenols extracted from several plants are reported to exhibit cariostatic activities by inhibiting mutans streptococcus growth and glucosyltransferase activities. The purpose of the present study was to examine the inhibitory effects of OBSE on the development of dental caries, both in vitro and in vivo. Methods: OBSE was investigated for its inhibitory effects on cellular aggregation, hydrophobicity, sucrose-dependent adherence and insoluble glucan synthesis. Furthermore, biofilm formation was examined in the presence of OBSE, using confocal microscopic imaging. An animal experiment was also performed to examine the in vivo effects. Results: OBSE induced a strong aggregation of Streptococcus mutans MT8148 cells, while cell surface hydrophobicity was decreased by approximately 90% at a concentration of 0.25 mg/ml. The sucrose-dependent adherence of the MT8148 cells was also reduced by addition of OBSE, with a reduction rate of 73% seen at a concentration of 1.00 mg/ml. Additionally, confocal microscopic observations revealed the biofilm development phase to be remarkably changed in the presence of OBSE. Furthermore, insoluble glucan synthesis was significantly reduced when OBSE was present at concentrations greater than 0.03 mg/ml. In an animal experiment, the caries scores in rats given OBSE (0.05 mg/ml in drinking water) were significantly lower than those in rats given water without OBSE. Conclusion: Our results indicate that OBSE has inhibitory activity on dental caries.

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Evening Primrose Oil in Patients With Rheumatoid Arthritis and Side-Effects of Non-Steroidal Anti-Inflammatory Drugs

Cited by 82 publications

References 0 publications

Mediterranean dietary intervention study of patients with rheumatoid arthritis

Mediterranean dietary intervention study of patients with rheumatoid arthritis

Potential of Evening Primrose, Borage, Black Currant, and Fungal Oils in Human Health

Inhibitory Effects of Oenothera biennis (Evening Primrose) Seed Extract on Streptococcus mutans and S. mutans-Induced Dental Caries in Rats

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