Evening vs morning isradipine sustained release in essential hypertension: a double‐blind study with 24 h ambulatory monitoring.

Fogari, Roberto; Malacco, Ettore; Tettamanti, F.; Gnemmi, A. E.; Milani, Massimo

doi:10.1111/j.1365-2125.1993.tb05670.x

Cited by 46 publications

(15 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…113,114 Also, regular as well as sustained-release verapamil displayed higher C max and/or shorter T max values after morning dosing 75,76 (Table 2). In primary (essential) hypertensives with a dipper profile, amlodipine, isradipine, nifedipine gastrointestinal therapeutic system, and nisoldipine did not affect the 24-hour BP profile differently after once-morning or once-evening dosing, [115][116][117][118][119] whereas with nitrendipine and lacidipine, the Note: NO χ is significantly higher in females than males (P , 0.05).…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

The importance of biological rhythms in drug treatment of hypertension and sex-dependent modifications

Lemmer

2012

CPT

View full text Add to dashboard Cite

Abstract:The cardiovascular system is highly organized in time. Blood pressure, heart rate, peripheral resistance, pressure, and vasodilating hormones display pronounced circadian variations. New data presented here demonstrate also sex-dependent differences in vasodilating hormones, with higher NO χ excretion in females than males and a steeper early morning rise in norepinephrine in males, whereas the 24-hour blood pressure and heart-rate profiles were not different. Various antihypertensive drugs were investigated in crossover studies -morning versus evening dosing -in hypertensive patients; however, consistent data were only described for angiotensin-converting-enzyme (ACE) inhibitors, calcium channel blockers, and angiotensin II type 1 (AT 1 ) receptor blockers. Whereas in dippers ACE inhibitors had a superdipping effect when dosed at night, no difference in the blood pressure lowering effect or on the 24-hour blood pressure profile was found with calcium channel blockers after morning and evening dosing. In nondippers, the calcium channel blockers isradipine and amlodipine transformed nondippers into dippers, similar after evening dosing. The effects of AT 1 -receptor blockers are similar to those of ACE inhibitors. Also, diuretics are able to normalize non dipping behavior. Moreover, a circadian phase dependency in their pharmacokinetics has been demonstrated for various cardiovascular-active drugs, such as beta blockers, calcium channel blockers, oral nitrates, and ACE inhibitors, modified by the galenic formulation. There is evidence that in hypertensive dippers, antihypertensive drugs should be given during early morning hours, whereas in non dippers it can be necessary to add an evening dose or even to apply a single evening dose in order not only to reduce high blood pressure, but also to normalize a disturbed non dipping 24-hour blood pressure profile.

show abstract

Section: Calcium Channel Blockersmentioning

confidence: 99%

The importance of biological rhythms in drug treatment of hypertension and sex-dependent modifications

Lemmer

2012

CPT

View full text Add to dashboard Cite

show abstract

“…These compounds were nisoldipine [9], fluoxetine [10], doxazosin [11,12], ranitidine, famotidine [13], lansoprazole [14], fluvastatin [15], isradipine [16], trandolapril [17], ciclesonide [18], and diltiazem [19], for which the recommendation was 'morning or evening' administration. On the other hand for 64% (21/33) of the listed drugs the administration at a specific time of the day significantly improved the outcome.…”

Section: Analysis Of Clinical Trialsmentioning

confidence: 99%

Appropriateness of timing of drug administration in electronic prescriptions

Hassan

Haefeli

2010

Pharm World Sci

View full text Add to dashboard Cite

show abstract

“…So far, this strategy has not produced very convincing results for controlling BP on rising. [47][48][49][50][51][52][53] • The use of an extended-action drug, taken in the morning, but whose effect continues for longer than 24 hours [54][55][56][57] • The use of drugs that are more specifically effective against the BP surge on rising, such as α blockers 58 and central α 2 agonists 59…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Early Morning Blood Pressure Surge

Gosse

Schumacher²

2006

J of Clinical Hypertension

View full text Add to dashboard Cite

lood pressure (BP) variation is a phenomenon that has been well known for many years, which to date has mainly been considered in relation to its consequences for the reliability of measurements. However, this variability also appears to be linked to the cardiovascular complications of hypertension, independent of the average BP level. Ambulatory techniques for monitoring BP are now facilitating the investigation of this phenomenon, in particular its circadian component. Two aspects of this circadian variation have been the subject of studies; however, results may seem contradictory. The loss of the nyctohemeral cycle of BP (nondipper profile) is accompanied by increased cardiovascular risk. The excessive morning BP surge, on rising, also appears to increase risk. This report summarizes the available data on the morning BP surge and its consequences and examines the relationship of the risks of this surge with the dangers of the nondipper profile. CIRCADIAN VARIATIONS OF BPThe development of automatic monitoring has led to the description of the circadian variation of BP. We must recall the pioneering work of Richardson and colleagues 1 who, with the assistance of an automatic device using the oscillometric method and the simultaneous recording of the electroencephalogram (EEG), wrote: "The pressure fell before EEG evidence of sleep, fell further during sleep and rose sharply in the morning after the subject woke." Fundamentally important observations were made by the use of continuous, uninterrupted, intra-arterial measurements using methodology developed by the Oxford team, 2,3 which clearly showed that BP was at its lowest during nighttime and rose in the morning to reach its highest values at midmorning. 4 These studies suggested that a BP surge in the early morning before waking was the result of an internal clock. This notion has been widely held for many years, but is an artifact that results from the likelihood that individuals who were studied awakened at different times. When the results are expressed in relation to the time of waking rather than the time of day, there is no longer any marked BP surge preceding this arousal. 5,6 R e v i e w P a p e r

show abstract

Evening vs morning isradipine sustained release in essential hypertension: a double‐blind study with 24 h ambulatory monitoring.

Cited by 46 publications

References 22 publications

The importance of biological rhythms in drug treatment of hypertension and sex-dependent modifications

The importance of biological rhythms in drug treatment of hypertension and sex-dependent modifications

Appropriateness of timing of drug administration in electronic prescriptions

Early Morning Blood Pressure Surge

Contact Info

Product

Resources

About