Evening vs. morning wake EEG activity in adolescents with anxiety disorders

Gauthier, Anne-Karine; Chevrette, Tommy; Bouvier, Hélène

doi:10.1016/j.janxdis.2008.04.005

Cited by 14 publications

(6 citation statements)

References 30 publications

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“…Consistent with these findings, a disruption in top-down PFC control mediated by an increased activation in the ventral portion of the anterior cingulate cortex (vACC) has been proposed to characterize individuals with psychopathology and, more intriguingly, to confer vulnerability to psychopathology (Beauchaine and Thayer, 2015). Given that increased slow wave EEG activity at rest has been reported in depression (Bjørk et al, 2008;Gatt et al, 2008;Korb et al, 2008), anxiety disorders (Gauthier et al, 2009;Velikova et al, 2010) and schizophrenia (Alfimova and Uvarova, 2003;Bates et al, 2009;Boutros et al, 2008), it can be speculated that the reduced integrity in the brain-heart network may be reflected by disrupted delta-HRV coupling in individuals with psychopathology. Clearly, future studies are warranted to test whether individuals with psychopathology, particularly those suffering from anxiety and depressive disorders, are characterized by abnormal delta-HRV coupling.…”

Section: Discussionmentioning

confidence: 91%

The frontal cortex is a heart-brake: Reduction in delta oscillations is associated with heart rate deceleration

et al. 2019

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Section: Discussionmentioning

confidence: 91%

The frontal cortex is a heart-brake: Reduction in delta oscillations is associated with heart rate deceleration

et al. 2019

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“…The alterations in δ -power also corroborate the anxiety findings. δ -frequency oscillations have been most closely tied to salience detection 63 , 64 , and anxiety as a heightened salience state is correspondingly linked to elevations in the δ -range 65 . Further, nonsedating doses of diazepam and other benzodiazepines are known to decrease δ -power 66 , 67 .…”

Section: Discussionmentioning

confidence: 99%

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

et al. 2018

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Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABAARs) that are enriched at functionally diverse synapses via mechanisms that remain unclear. Using isothermal titration calorimetry and complementary methods we demonstrate an exclusive low micromolar binding of collybistin to the α2-subunit of GABAARs. To explore the biological relevance of collybistin-α2-subunit selectivity, we generate mice with a mutation in the α2-subunit-collybistin binding region (Gabra2-1). The mutation results in loss of a distinct subset of inhibitory synapses and decreased amplitude of inhibitory synaptic currents. Gabra2–1 mice have a striking phenotype characterized by increased susceptibility to seizures and early mortality. Surviving Gabra2-1 mice show anxiety and elevations in electroencephalogram δ power, which are ameliorated by treatment with the α2/α3-selective positive modulator, AZD7325. Taken together, our results demonstrate an α2-subunit selective binding of collybistin, which plays a key role in patterned brain activity, particularly during development.

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“…Existing evidence shows that delta activity increases in pathological conditions correlated with neuronal damage and even in anxiety ( Gauthier, Chevrette, Bouvier, & Godbout, 2009 ). On the other hand, cognitive neuro-scientists describe delta as a cognitive rhythm ( Knyazev, 2007 ) that is linked to attention ( Knyazev, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

A Neurochemical and Electrophysiological Study on the Combined Effects of Caffeine and Nicotine in the Cortex of Rats

Mourad

Noor

Mohammed

et al. 2021

BCN

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Objective: Caffeine and nicotine are the most consumed psychostimulants worldwide. Although the effects of each drug alone on the central nervous system (CNS) were studied extensively, the literature on the neurochemical and electrophysiological effects of their combined treatments is scarce. The present study investigates the cortical electrophysiological and neurochemical alterations induced by acute administration of caffeine and nicotine in rats. Methods: Rats received caffeine and nicotine with 1h interval between the two treatments. Results: Caffeine and nicotine administration resulted in a significant decrease in the concentrations of cortical amino acid neurotransmitters namely glutamate, aspartate, glycine and taurine while γ-aminobutyric acid (GABA) was significantly increased. An increased cortical lipid peroxidation and decreased reduced glutathione and nitric oxide levels and acetylcholinesterase and Na+, K+-ATPase activities were also observed. The electroencephalogram (EEG) showed an increase in delta frequency power band while theta, beta-1 and beta-2 were decreased after caffeine and nicotine treatment. These findings suggest that caffeine and nicotine adversely exacerbate their stimulant effects. This was manifested by the EEG changes and mediated by increasing cholinergic transmission, disturbing the balance between the excitatory and inhibitory amino acids leading to oxidative stress.

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Evening vs. morning wake EEG activity in adolescents with anxiety disorders

Cited by 14 publications

References 30 publications

The frontal cortex is a heart-brake: Reduction in delta oscillations is associated with heart rate deceleration

The frontal cortex is a heart-brake: Reduction in delta oscillations is associated with heart rate deceleration

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

A Neurochemical and Electrophysiological Study on the Combined Effects of Caffeine and Nicotine in the Cortex of Rats

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