Event-related brain potentials in response to novel sounds in dementia

Yamaguchi, Shûhei; Tsuchiya, H.; Yamagata, S; Toyoda, Genya; Kobayashi, Shotai

doi:10.1016/s1388-2457(99)00228-x

Cited by 68 publications

(69 citation statements)

References 35 publications

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“…This potential has been called the "novelty P300" and is interpreted as reflecting frontal lobe activity related to the hippocampus (Grunwald et al, 1998;Knight, 1996). It is observed across modalities (Fabiani et al, 1998;Yamaguchi and Knight, 1991) and populations Knight, 1987;Yamaguchi et al, 2000). With repeated stimulus presentation, novelty P300 decreases in amplitude so that it may be more directly related to the orienting response than the P3b (Knight, 1984;Kok, 2001;Riggins and Polich, 2003;Rushby et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

6,465

458

6,265

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The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/ standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulusdriven frontal attention mechanisms during task processing, whereas P3b originates from temporalparietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

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Section: Introductionmentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

6,465

458

6,265

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“…The protocol originally described by [2], with slight modifications was used in this study. Binaural audiometric thresholds were determined for each subject using a 1000Hz tone.…”

Section: B Acquisition Of Event Related Potentialsmentioning

confidence: 99%

“…The distinguishing feature of the P300 is that it only occurs in response to the oddball stimulus. Changes in the amplitude and latency of ERPs are altered by neurological disorders affecting the temporalparietal regions of the brain [2]. This includes AD where the average stimulus to P300 latency is prolonged and the amplitude decreased compared to controls.…”

Section: Introductionmentioning

confidence: 99%

Multiresolution analysis for early diagnosis of Alzheimer's disease

Jacques

Stevenson²,

Kounios³

et al.

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Early diagnosis of Alzheimer's disease is a major concern due to large portions of the elderly population it affects and the lack of a standard and effective diagnosis procedure that is available to community healthcare providers. Several studies have been performed using wavelets or other signal processing methods to analyze EEG signals in an attempt to find a biomarker for Alzheimer's disease, which showed varying degrees of success. To date, in part due to lack of a large study cohort, the results of these studies remain largely inconclusive. In this paper, we describe a new effort using multiresolution wavelet analysis on event related potentials of the EEG to investigate whether such a link can be established. Several factors sets this study apart from similar prior efforts: We use a larger cohort, compare different mother wavelets, rather then using one generic wavelet, and most importantly, we specifically target early diagnosis of the disease. Our multi-year effort will include a total of 80 patients, whose ERPs will be analyzed with several different wavelets and automated classifiers. We present some preliminary, yet very promising, results on analysis of EEGs of the first 28 patients analyzed thus far using two types of wavelets.

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“…The protocol originally described in [3] was followed with slight modifications. The evoked response stimulus was presented to both of the subject's ears using stereo speakers with an amplitude level comfortable for their hearing.…”

Section: Data Acquisitionmentioning

confidence: 99%

“…The ERPs show a positive peak called the P3 (or P300) with an approximate latency of 300 ms after the oddball stimulus. Changes in the amplitude and latency of the P300 are known to be altered by neurological disorders affecting the temporal-parietal regions of the brain [3]. Polich et al have reported that latency and the amplitude of the P300 are in fact altered in patients with AD when compared to elderly control subjects [4,5].…”

Section: Introductionmentioning

confidence: 99%

Majority Vote and Decision Template Based Ensemble Classifiers Trained on Event Related Potentials for Early Diagnosis of Alzheimer's Disease

Stepenosky

Green

Kounios

et al.

2006 IEEE International Conference on Acoustics Speed and Signal Processing Proceedings

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With the rapid increase in the population of elderly individuals affected by Alzheimer's disease, the need for an accurate, inexpensive and non-intrusive diagnostic biomarker that can be made available to community healthcare providers presents itself as a major public health concern. The feasibility of EEG as such a biomarker has gained a renewed attention as several recent studies, including our previous efforts, reported promising results. In this paper we present our preliminary results on using wavelet coefficients of event related potentials along with an ensemble of classifiers combined with majority vote and decision templates.

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Event-related brain potentials in response to novel sounds in dementia

Cited by 68 publications

References 35 publications

Updating P300: An integrative theory of P3a and P3b

Updating P300: An integrative theory of P3a and P3b

Multiresolution analysis for early diagnosis of Alzheimer's disease

Majority Vote and Decision Template Based Ensemble Classifiers Trained on Event Related Potentials for Early Diagnosis of Alzheimer's Disease

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