Event-Related Potential Studies of Cognitive Processing Abnormalities in Autism

Sokhadze, Estate M.; Baruth, Joshua M.; Tasman, Allan

doi:10.1007/978-1-4614-6843-1_4

Cited by 4 publications

(9 citation statements)

References 162 publications

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“…Response-locked EEGs were segmented into 500 ms pre-response to 500 ms post-response (i.e., commission error). More detailed account for experimental procedure and EEG data acquisition and processing can be found in our prior publications that used similar methodology (Baruth et al 2010ab; Casanova et al 2012; Sokhadze et al 2012ab, 2013a). …”

Section: Methodsmentioning

confidence: 99%

“…Perception and sensory reactivity abnormalities are found in majority of subjects with ASD affecting their ability to effectively process information (Gomes et al 2008). In a series of electrophysiological studies conducted by our group we explored specifics of event-related potentials (i.e., ERP) reflecting information processing during performance on reaction time tasks in children with ASD ( Baruth et al 2010c ; Casanova et al 2012; Sokhadze et al 2009ab, 2012b, 2013a ). Our studies were aimed to explore the manifestations of the impaired functional connectivity, excessive cortical excitation/inhibition ratio (i.e., E/I), and deficient executive functioning in ASD by analyzing behavioral performance on attention tasks with dense-array ERP recording.…”

Section: Introductionmentioning

confidence: 99%

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Neuromodulation Integrating rTMS and Neurofeedback for the Treatment of Autism Spectrum Disorder: An Exploratory Study

Sokhadze

El-Baz

Tasman

et al. 2014

Appl Psychophysiol Biofeedback

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Autism spectrum disorder (ASD) is a pervasive developmental disorder characterized by deficits in social interaction, language, stereotyped behaviors, and restricted range of interests. In previous studies low frequency repetitive transcranial magnetic stimulation (rTMS) has been used, with positive behavioral and electrophysiological results, for the experimental treatment in ASD. In this study we combined prefrontal rTMS sessions with electroencephalographic (EEG) neurofeedback (NFB) to prolong and reinforce TMS-induced EEG changes. The pilot trial recruited 42 children with ASD (~14.5 yrs). Outcome measures included behavioral evaluations and reaction time test with event-related potential (ERP) recording. For the main goal of this exploratory study we used rTMS-neurofeedback combination (TMS-NFB, N=20) and waitlist (WTL, N=22) groups to examine effects of 18 sessions of integrated rTMS-NFB treatment or wait period) on behavioral responses, stimulus and response-locked ERPs, and other functional and clinical outcomes. The underlying hypothesis was that combined TMS-NFB will improve executive functions in autistic patients as compared to the waitlist group. Behavioral and ERP outcomes were collected in preand post-treatment tests in both groups. Results of the study supported our hypothesis by demonstration of positive effects of combined TMS-NFB neurotherapy in active treatment group as compared to control waitlist group, as the TMS-NFB group showed significant improvements in behavioral and functional outcomes as compared to the waitlist group.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuromodulation Integrating rTMS and Neurofeedback for the Treatment of Autism Spectrum Disorder: An Exploratory Study

Sokhadze

El-Baz

Tasman

et al. 2014

Appl Psychophysiol Biofeedback

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“…Results partially replicate our earlier ERP findings in autism. Our prior studies showed similar group differences in reaction time tasks using two different types of visual three-stimulus oddball tests, including one with illusory Kanizsa figures as the stimuli [ 3 , 4 , 5 , 6 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 71%

“…These perception and sensory reactivity abnormalities, found in a majority of subjects with ASD, affect their ability to effectively process information [ 2 ]. In a series of electrophysiological studies conducted by our group we explored specifics of event-related potential (i.e., ERP) reflecting information processing during performance on reaction time (RT) tasks in children with ASD [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Our prior studies explored the manifestations of excessive local connectivity and impaired distal functional connectivity, excessive cortical excitation/inhibition ratio, and deficient executive functioning in ASD by analyzing behavioral performance on attention tasks with concurrent dense-array ERP recording.…”

Section: Introductionmentioning

confidence: 99%

“…Our prior studies explored the manifestations of excessive local connectivity and impaired distal functional connectivity, excessive cortical excitation/inhibition ratio, and deficient executive functioning in ASD by analyzing behavioral performance on attention tasks with concurrent dense-array ERP recording. More detailed theoretical considerations related to the results of these studies were discussed in our reviews on this topic [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Atypical Processing of Novel Distracters in a Visual Oddball Task in Autism Spectrum Disorder

Sokhadze

Lamina

Casanova

et al. 2017

Behavioral Sciences

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Several studies have shown that children with autism spectrum disorder (ASD) show abnormalities in P3b to targets in standard oddball tasks. The present study employed a three-stimulus visual oddball task with novel distracters that analyzed event-related potentials (ERP) to both target and non-target items at frontal and parietal sites. The task tested the hypothesis that children with autism are abnormally orienting attention to distracters probably due to impaired habituation to novelty. We predicted a lower selectivity in early ERPs to target, frequent non-target, and rare distracters. We also expected delayed late ERPs in autism. The study enrolled 32 ASD and 24 typically developing (TD) children. Reaction time (RT) and accuracy were analyzed as behavioral measures, while ERPs were recorded with a dense-array EEG system. Children with ASD showed higher error rate without normative post-error RT slowing and had lower error-related negativity. Parietal P1, frontal N1, as well as P3a and P3b components were higher to novels in ASD. Augmented exogenous ERPs suggest low selectivity in pre-processing of stimuli resulting in their excessive processing at later stages. The results suggest an impaired habituation to unattended stimuli that incurs a high load at the later stages of perceptual and cognitive processing and response selection when novel distracter stimuli are differentiated from targets.

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Clinical Applications of Electrophysiological Approaches Based on Cortical Modularity in Autism

Sokhadze

Sears

El-Baz

et al. 2015

Recent Advances on the Modular Organization of the Cortex

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Event-Related Potential Studies of Cognitive Processing Abnormalities in Autism

Cited by 4 publications

References 162 publications

Neuromodulation Integrating rTMS and Neurofeedback for the Treatment of Autism Spectrum Disorder: An Exploratory Study

Neuromodulation Integrating rTMS and Neurofeedback for the Treatment of Autism Spectrum Disorder: An Exploratory Study

Atypical Processing of Novel Distracters in a Visual Oddball Task in Autism Spectrum Disorder

Clinical Applications of Electrophysiological Approaches Based on Cortical Modularity in Autism

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