Event-related potentials, cognition, and behavior: A biological approach

Kotchoubey, Boris

doi:10.1016/j.neubiorev.2005.04.002

Cited by 102 publications

(67 citation statements)

References 242 publications

(266 reference statements)

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“…We have argued that the integrative processes underlying the amplitude of the P600 can best be understood in terms of the construction, reorganization, or updating of a mental representation of what is being communicated in a sentence or story -a proposal we have labeled the MRC hypothesis. Language processing thus seems to be basically characterized by biphasic N400/P600 sequences occurring for every word in a sentence (see Kotchoubey, 2006, for a proposal in which all cognitive processing entails negative-positive cycles). Future research should address how this account can be extended to include other ERPeffects that have been found in language processing studies, such as the Early Left Anterior Negativity (ELAN), the Left Anterior Negativity (LAN), as well as Sustained Negativities (see Friederici, 2011;Steinhauer and Drury, 2011, for critical reviews).…”

Section: Resultsmentioning

confidence: 99%

Getting real about Semantic Illusions: Rethinking the functional role of the P600 in language comprehension

2012

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In traditional theories of language comprehension, syntactic and semantic processing are inextricably linked. This assumption has been challenged by the 'Semantic Illusion Effect' found in studies using Event Related brain Potentials. Semantically anomalous sentences did not produce the expected increase in N400 amplitude but rather one in P600 amplitude. To explain these findings, complex models have been devised in which an independent semantic processing stream can arrive at a sentence interpretation that may differ from the interpretation prescribed by the syntactic structure of the sentence. We review five such multi-stream models and argue that they do not account for the full range of relevant results because they assume that the amplitude of the N400 indexes some form of semantic integration. Based on recent evidence we argue that N400 amplitude might reflect the retrieval of lexical information from memory. On this view, the absence of an N400-effect in Semantic Illusion sentences can be explained in terms of priming. Furthermore, we suggest that semantic integration, which has previously been linked to the N400 component, might be reflected in the P600 instead. When combined, these functional interpretations result in a single-stream account of language processing that can explain all of the Semantic Illusion data.

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Section: Resultsmentioning

confidence: 99%

Getting real about Semantic Illusions: Rethinking the functional role of the P600 in language comprehension

2012

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“…However, we report clear group differences in the P3b response to deviant tones, which confirms that patients with cerebellar lesions cannot benefit in a similar way as healthy controls from temporal predictability. Considering the 'almost unquestionable' [33] agreement of P300 theories on the function of this component as an index for the interplay of stimulus expectancies and actual sensory input, it seems appropriate to interpret this finding as an instance of impaired updating of a mental model of the environment. This result substantiates the critical role of the cerebellum in event-based temporal encoding [4,14,39] and the optimized adaptation to change in the environment (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…However, the P3b is typically believed to instantiate a neural signature of a change in this model, conceived as a general schema of all available data in the environment and of the stimulus context, in particular [29,31]. With respect to the oddball paradigm used here this suggests that the model established by frequent standard tones has to be transformed (updated) when an infrequent deviant tone is encountered, reflecting the mediation between the participants' expectancies and sensory input [32,33]. We expected that healthy controls would show an N2b response to deviant tones in both types of sequences and a further enhanced P3b response to deviant tones in temporally regular compared with irregular tone sequences [24] reflecting the beneficial effects of temporal regularity on deviance processing and, in turn, effective updating of a mental model of the environment.…”

Section: Introductionmentioning

confidence: 99%

Cerebellum, temporal predictability and the updating of a mental model

Kotz

Stockert

Schwartze

2014

Phil. Trans. R. Soc. B

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We live in a dynamic and changing environment, which necessitates that we adapt to and efficiently respond to changes of stimulus form ('what') and stimulus occurrence ('when'). Consequently, behaviour is optimal when we can anticipate both the 'what' and 'when' dimensions of a stimulus. For example, to perceive a temporally expected stimulus, a listener needs to establish a fairly precise internal representation of its external temporal structure, a function ascribed to classical sensorimotor areas such as the cerebellum. Here we investigated how patients with cerebellar lesions and healthy matched controls exploit temporal regularity during auditory deviance processing. We expected modulations of the N2b and P3b components of the event-related potential in response to deviant tones, and also a stronger P3b response when deviant tones are embedded in temporally regular compared to irregular tone sequences. We further tested to what degree structural damage to the cerebellar temporal processing system affects the N2b and P3b responses associated with voluntary attention to change detection and the predictive adaptation of a mental model of the environment, respectively. Results revealed that healthy controls and cerebellar patients display an increased N2b response to deviant tones independent of temporal context. However, while healthy controls showed the expected enhanced P3b response to deviant tones in temporally regular sequences, the P3b response in cerebellar patients was significantly smaller in these sequences. The current data provide evidence that structural damage to the cerebellum affects the predictive adaptation to the temporal structure of events and the updating of a mental model of the environment under voluntary attention.

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“…As for polarity, ERP components show voltage deflections (expressed in mV) that are either positive or negative. Animal studies have suggested that the polarity of ERPs is related to either excitation or inhibition of cells, yet with a complex neural generation process (see [10] for a review). Simply put, neuronal discharges/firing in thalamo-cortical cells generally result in negative ERP components, while cellular inhibition underlies positive potentials [11].…”

Section: Basic Neurophysiology and Terminologymentioning

confidence: 99%

An introduction to the measurement of auditory event-related potentials (ERPs)

Remijn

Hasuo

Fujihira

et al. 2014

Acoust. Sci. & Tech.

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In 1939, Pauline Davis reported the first study on event-related potentials (ERPs) performed on awake humans. ERPs are time-locked brain potentials that occur in response to cognitive, motor or perceptual events. The events used by Davis were sounds, and in the decades that followed her landmark study ERP research significantly contributed to the knowledge of auditory perception and neurophysiology we have today. ERPs are very well suited to study neural responses to sound stimuli, since the researcher can monitor the brain's registration of sound edges and spectral changes in sound on a millisecond-by-millisecond basis. In this overview we will introduce basic concepts of auditory ERP research. The overview includes descriptions of typical ERP components, experimental paradigms, sound stimuli, research methodology, and ways to analyze data.

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Event-related potentials, cognition, and behavior: A biological approach

Cited by 102 publications

References 242 publications

Getting real about Semantic Illusions: Rethinking the functional role of the P600 in language comprehension

Getting real about Semantic Illusions: Rethinking the functional role of the P600 in language comprehension

Cerebellum, temporal predictability and the updating of a mental model

An introduction to the measurement of auditory event-related potentials (ERPs)

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