Evidence against Barium in the Mushroom Trogia venenata as a Cause of Sudden Unexpected Deaths in Yunnan, China

Zhang, Ying; Li, Yan Chun; Wu, Gang; Feng, Bang; Yoell, Shanze; Yu, Zefen; Zhang, Ke‐Qin; Xu, Jianping

doi:10.1128/aem.01798-12

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…These mushrooms also contain the proconvulsant toxin, gammaguanidinobutyric acid, which is structurally similar to GABA [22,66]. The exact toxin responsible for the syndrome is not yet well established [67,68] Initially, patients report nausea, vomiting, diarrhea, abdominal pain, and fatigue. Recurrent syncope and eventual sudden unexpected death may occur.…”

Section: Cardiotoxins and Sudden Deathmentioning

confidence: 99%

Mycetism: A Review of the Recent Literature

Graeme

2014

J. Med. Toxicol.

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Approximately 100 of the known species of mushrooms are poisonous to humans. New toxic mushroom species continue to be identified. Some species initially classified as edible are later reclassified as toxic. This results in a continually expanding list of toxic mushrooms. As new toxic species are identified, some classic teachings about mycetism no longer hold true. As more toxic mushrooms are identified and more toxic syndromes are reported, older classification systems fail to effectively accommodate mycetism. This review provides an update of myscetism and classifies mushroom poisonings by the primary organ system affected, permitting expansion, as new, toxic mushroom species are discovered.

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Section: Cardiotoxins and Sudden Deathmentioning

confidence: 99%

Mycetism: A Review of the Recent Literature

Graeme

2014

J. Med. Toxicol.

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“…venenata in humans [ 6 , 55 ]. However, as discussed in Zhang et al [ 17 ], the two amino acids in T . venenata could not explain all the SUDs cases.…”

Section: Discussionmentioning

confidence: 99%

“…However, a later analysis refuted the hypothesis that this mushroom preferentially accumulated barium in its fruiting bodies and concluded that barium in T . venenata was unlikely a contributor to SUDs [ 17 ]. Despite the negative finding, much remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Evidence for Inbreeding and Genetic Differentiation among Geographic Populations of the Saprophytic Mushroom Trogia venenata from Southwestern China

Zhang

Yang

et al. 2016

PLoS ONE

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During the past 40 years, more than 400 Sudden Unexplained Deaths (SUDs) have occurred in Yunnan, southwestern China. Epidemiological and toxicological analyses suggested that a newly discovered mushroom called Trogia venenata was the leading culprit for SUDs. At present, relatively little is known about the genetics and natural history of this mushroom. In this study, we analyzed the sequence variation at four DNA fragments among 232 fruiting bodies of T. venenata collected from seven locations. Our ITS sequence analyses confirmed that all the isolates belonged to the same species. The widespread presence of sequence heterozygosity within many strains at each of three protein-coding genes suggested that the fruiting bodies were diploid, dikaryotic or heterokaryotic. Within individual geographic populations, we found significant deviations of genotype frequencies from Hardy-Weinberg expectations, with the overall observed heterozygosity lower than that expected under random mating, consistent with prevalent inbreeding within local populations. The geographic populations were overall genetically differentiated. Interestingly, while a positive correlation was found between population genetic distance and geographic distance, there was little correlation between genetic distance and barium concentration difference for the geographic populations. Our results suggest frequent inbreeding, geographic structuring, and limited gene flow among geographic populations of T. venenata from southwestern China.

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Mycotoxins and Human Disease

Barać

2018

Clinically Relevant Mycoses

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Evidence against Barium in the Mushroom Trogia venenata as a Cause of Sudden Unexpected Deaths in Yunnan, China

Cited by 4 publications

References 16 publications

Mycetism: A Review of the Recent Literature

Mycetism: A Review of the Recent Literature

Evidence for Inbreeding and Genetic Differentiation among Geographic Populations of the Saprophytic Mushroom Trogia venenata from Southwestern China

Mycotoxins and Human Disease

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