“…Interest has grown regarding the assessment and management of pain in AD (Gagliese, 2009) and it has been estimated that 50–93% of AD patients suffer from a pain condition (Abdulla et al, 2013, Corbett et al, 2014, van Kooten et al, 2015, Whitlock et al, 2017). Neurodegenerative changes – often observed in AD – have been shown to occur in brain regions associated with pain processing including the locus coeruleus, hypothalamus, periaqueductal grey, anterior cingulate cortex, insula and amygdala (Cole et al, 2006, Scherder et al, 2003, Stubbs et al, 2016, Zarow et al, 2003).…”