Evidence-Based, Non-Surgical Treatments for Vitiligo

Bacigalupi, Robert; Postolova, Anna; Davis, Ronald S.

doi:10.2165/11630540-000000000-00000

Cited by 27 publications

(16 citation statements)

References 48 publications

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“…Topical and systemic corticosteroids, topical calcineurin inhibitors, calcipotriol, phototherapy, excimer laser and surgical methods, such as skin/single-hair grafting, or autologous cultured melanocyte or epidermal suspension transplantations have been used with different results [2, 3]. Among these treatments, phototherapy and topical steroids are the most widely documented [5, 10].…”

Section: Discussionmentioning

confidence: 99%

Narrow Band-Ultraviolet B Versus Clobetasol Propionate Foam in the Treatment of Vitiligo: A Retrospective Study

Stinco

Trevisan

Buligan

et al. 2013

Dermatol Ther (Heidelb)

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IntroductionSeveral therapeutic options are available for the treatment of vitiligo; among these phototherapy and topical steroids are the most widely documented. A topical formulation of 0.05% clobetasol propionate foam (CPF) has been introduced in the market, but no data are available about the efficacy and tolerability of this new formulation in the treatment of vitiligo. The aim of this study was to investigate the efficacy and tolerability of CPF in the treatment of vitiligo, in comparison with narrowband-ultraviolet B (NB-UVB) phototherapy.MethodsThe medical records of the first 60 vitiligo patients treated with NB-UVB phototherapy or with CPF were selected. Response to the treatment was determined for each anatomic site (neck, upper and lower limbs, trunk, hands/wrists, feet/ankles). Based on the area of repigmentation, treatment outcome was calculated according to a scale ranging from 0 (absent) to 4 (excellent). The incidence of adverse effects was also noted as a secondary endpoint. Significance level was set at P = 0.05.ResultsFor each anatomic site, statistical analyses demonstrated that the efficacy of CPF was significantly higher compared to NB-UVB. Side effects occurred in 4 patients (13.33%) in the CPF group compared to none in the NB-UVB group.DiscussionClobetasol propionate has been used in vitiligo in different vehicles, but never in foam. The data showed that CPF is effective and seems to be superior to NB-UVB phototherapy, with furthermore a good safety profile.ConclusionThis new foam formulation of clobetasol propionate may expand the options currently available for vitiligo therapy; however, further investigations are needed to confirm our preliminary observations.

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Section: Discussionmentioning

confidence: 99%

Narrow Band-Ultraviolet B Versus Clobetasol Propionate Foam in the Treatment of Vitiligo: A Retrospective Study

Stinco

Trevisan

Buligan

et al. 2013

Dermatol Ther (Heidelb)

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“…Therapeutic strategies for vitiligo include nonsurgical and surgical methods. Nonsurgical options like psoralen and ultraviolet A (PUVA), narrow‐band ultraviolet B (NB‐UVB), corticosteroids, topical calcipotriol, and tacrolimus . Surgical methods such as skin grafting, autologous cultured melanocyte, or epidermal suspension transplantations .…”

Section: Introductionmentioning

confidence: 99%

Comparison between the efficacy of microneedling combined with 5‐fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo

Mina

Elgarhy

Al-saeid

et al. 2018

J of Cosmetic Dermatology

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“…4 More and more dermatologists across the world have started to prescribe PUVA therapy, and for many patients, it has become the first-choice treatment for the effective control of psoriasis. 5,6 Treatment with psoralen may increase tyrosinase activity and promote melanin synthesis in normal melanocytes adjacent to the damaged cells. 7,8 The conventional formulations of psoralen, such as tinctures and ointments, have weak percutaneous permeability and poor deposition in the skin, which usually leads to frequent administration and may cause adverse reactions.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

Zhang

Shen

Zhao

2014

IJN

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This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats. We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition. Using in vitro and in vivo methods, we investigated skin penetration and release from psoralen-loaded ethosomes in comparison with an ethanol tincture. In in vitro studies, the use of ethosomes was associated with a 6.56-fold greater skin deposition of psoralen than that achieved with the use of the tincture. In vivo skin microdialysis showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3.37 and 2.34 times higher, respectively, than those of psoralen from the tincture. Moreover, it revealed that the percutaneous permeability of ethosomes was greater when applied to the abdomen than when applied to the chest or scapulas. Enhanced permeation and skin deposition of psoralen delivered by ethosomes may help reduce toxicity and improve the efficacy of long-term psoralen treatment.

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Evidence-Based, Non-Surgical Treatments for Vitiligo

Cited by 27 publications

References 48 publications

Narrow Band-Ultraviolet B Versus Clobetasol Propionate Foam in the Treatment of Vitiligo: A Retrospective Study

Narrow Band-Ultraviolet B Versus Clobetasol Propionate Foam in the Treatment of Vitiligo: A Retrospective Study

Comparison between the efficacy of microneedling combined with 5‐fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo

Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

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