2007
DOI: 10.1182/asheducation-2007.1.172
|View full text |Cite
|
Sign up to set email alerts
|

Evidence-Based Platelet Transfusion Guidelines

Abstract: Transfused platelets (plts) are either pooled random-donor platelet (plt) concentrates or single-donor apheresis plts. When stored for 5 days, all of these products are equally efficacious.A 10,000/μL prophylactic plt transfusion trigger has been documented to be both hemostatically efficacious and cost effective in reducing plt transfusion requirements. The optimal plt dose/transfusion is being evaluated in an ongoing clinical trial. Therapeutic plt transfusions to control or prevent bleeding with trauma or s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
175
0
2

Year Published

2012
2012
2017
2017

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 230 publications
(178 citation statements)
references
References 36 publications
1
175
0
2
Order By: Relevance
“…23,24 The analysis of the 95 patients (41%) who did not achieve a stable response showed that, despite most of them needing multiple lines of further treatments, a new response was achieved in 83% of the cases, confirming that splenectomy can convert refractory patients into responding ones, and does not exclude the possibility of a second response in relapsing patients. 19,20 Indeed, only 16 patients (7%) did not respond to any further treatment and only 3 (1%) died of bleeding complications. Overall, refractory disease correlated to a higher incidence of infectious complications (42 vs. 24% in stable responders; P=0.004), probably due to the need for extensive immunosuppressive treatments (Table 3).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…23,24 The analysis of the 95 patients (41%) who did not achieve a stable response showed that, despite most of them needing multiple lines of further treatments, a new response was achieved in 83% of the cases, confirming that splenectomy can convert refractory patients into responding ones, and does not exclude the possibility of a second response in relapsing patients. 19,20 Indeed, only 16 patients (7%) did not respond to any further treatment and only 3 (1%) died of bleeding complications. Overall, refractory disease correlated to a higher incidence of infectious complications (42 vs. 24% in stable responders; P=0.004), probably due to the need for extensive immunosuppressive treatments (Table 3).…”
Section: Discussionmentioning
confidence: 99%
“…Hemorrhage was graded according to the WHO scale. 19 The study was approved by the ethics committees of participating centers. The study was conducted in accordance with the Declaration of Helsinki.…”
Section: Study Design and Definitionsmentioning
confidence: 99%
“…33,78 In many ICU patients, thrombocytopenia is associated with acquired mild to moderate platelet function defects, [79][80][81] which are caused or aggravated by medications such as antibiotics and 82,83 analgesics, platelet activation on extracorporeal circuits, 84 or cleavage of platelet receptors by released enzymes in cases of sepsis. 28 Therefore, in thrombocytopenic patients, bleeding symptoms are much more relevant than the platelet count when deciding whether platelets should be transfused.…”
Section: Platelet Transfusions In Icu Patientsmentioning
confidence: 99%
“…In general, they recommend prophylactic platelet transfusions at a transfusion trigger of 10×10 9 / L 4,5,6,7 The use of therapeutic platelets is only recommended when there is significant bleeding or when an invasive intervention is anticipated.…”
Section: Prophylactic Platelet Transfusionsmentioning
confidence: 99%