Patients with severe thrombocytopenia are presumed to be at increased risk for bleeding, and consequently it has been standard practice for the past four decades to give allogeneic platelet transfusions to severely thrombocytopenic patients as supportive care. Platelet transfusions may be given either prophylactically to reduce the risk of bleeding, in the absence of clinical hemorrhage (prophylactic transfusions), or to control active bleeding when present (therapeutic transfusions). Platelets for transfusion can be prepared either by separation of units of platelet concentrates (PCs) from whole blood, which are pooled before administration, or by apheresis from single donors. Comparative studies have shown that the post transfusion increments, hemostatic benefit, and side effects are similar with either product. Thus, in routine circumstances, they can be used interchangeably. In most centers, pooled PCs are less costly. Single-donor platelets from selected donors are preferred when histocompatible platelet transfusions are needed. Both preparations can be stored for up to 5 days after collection at 20°C to 24°C with good maintenance of platelet viability. It is now uncommon for patients undergoing intensive chemotherapy or bone marrow transplantation to die of hemorrhage, but it is open to debate as to what degree platelet transfusions have been responsible for this change in outcome, given the many other advances in other aspects of supportive care.Anwer Khan Modern Medical College Journal Vol. 6, No. 2: July 2015, P 40-46
Context: The possibility of hepatitis transmission through blood and blood products is very high and pretransfusion screening is mandatory by law in our country. The present study was carried out to find out the prevalence of Hepatitis B virus positive (HBsAg positive) among the blood donors attended the Department of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, in 2012. Method: This cross sectional study was carried out in the Department of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, between January and December 2012. Total blood donors were 27,560. Blood donors of 18-60 years of both sexes were included in this study. Results: Among 27,560 blood donors, relative blood donors were 21,081 (76.49%) and voluntary blood donors were 6,479 (23.50%). Among total blood donors male and female were 23,776 (86.26%) and 3784 (13.73%) respectively. 25,906 (93.99%) were in 18-40 years age group and 1,654 (6%) were in 41-60 years age group. A total of 453 were detected as HBsAg seropostive. Among them, relatives of the patients were 363 (1.7%) and voluntary donors were 90 (1.4%). DOI: http://dx.doi.org/10.3329/jdmc.v22i2.21528 J Dhaka Medical College, Vol. 22, No.2, October, 2013, Page 163-166
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