Evidence based review of literature on detriments to healing of diabetic foot ulcers

Lefrancois, Tina; Mehta, Kinjal; Sullivan, Victoria; Lin, Sheldon S.; Glazebrook, Mark

doi:10.1016/j.fas.2016.04.002

Cited by 24 publications

(21 citation statements)

References 104 publications

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“…Chronic wounds, which have the characteristics of complex pathogenesis, prolonged disease, easy recurrence, prolonged treatment time, high cost, and high disability rate, refer to wounds that cannot attain anatomical and functional wound healing standards after regular treatment for 4 weeks or more [44]. Most recalcitrant wounds result from pressure ulcers [45], diabetic ulcers [46], venous ulcers [47], vascular insufficiency (e.g., arteriosclerosis [48] or critical limb ischemia [49]), and trauma such as burns [50] and frostbite [51]. Difficulties associated with chronic wound healing have primarily been ascribed to a lack of angiogenesis [52].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

et al. 2019

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Ischemic diseases, which are caused by a reduction of blood supply that results in reduced oxygen transfer and nutrient uptake, are becoming the leading cause of disabilities and deaths. Therapeutic angiogenesis is key for the treatment of these diseases. Stem cells have been used in animal models and clinical trials to treat various ischemic diseases. Recently, the efficacy of stem cell therapy has increasingly been attributed to exocrine functions, particularly extracellular vesicles. Extracellular vesicles are thought to act as intercellular communication vehicles to transport informational molecules including proteins, mRNA, microRNAs, DNA fragments, and lipids. Studies have demonstrated that extracellular vesicles promote angiogenesis in cellular experiments and animal models. Herein, recent reports on the use of extracellular vesicles for therapeutic angiogenesis during ischemic diseases are presented and discussed. We believe that extracellular vesicles-based therapeutics will be an ideal treatment method for patients with ischemic diseases.

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Section: Introductionmentioning

confidence: 99%

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

et al. 2019

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“…Deaths from wound infections that spread to the heart will not occur if wound care is done early on. There were 7 factors that inhibit wound healing consists of age, infection, hypovolemia, hematoma, foreign body, ischemia, diabetes and treatment (Lefrancois et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Home Care by Ozone Bagging towards Diabetic Foot Ulcers Healing

Mediarti

Rehana

Arifin

2018

Proceedings of the 9th International Nursing Conference

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The global prevalence of DM patients in 2014 is 8.3% of the total population in the world. Increased prevalence of DM followed by increased incidence of diabetic foot ulcers. The American Diabetes Association mentioned that in 2010 there were approximately 73,000 cases of non-traumatic limb amputations with a diagnosis of DM. The purpose of this study was to determine the effect of home care with modern wound care: ozone bagging towards diabetic foot ulcers healing in Palembang. This research used quantitative and qualitative approach with mixed methodology design. The samples obtained 42 people by purposive sampling technique. Quantitative analysis used dependent samples paired t-test and qualitative used non-statistical analysis through logical inference based on actual considerations and conditions. The average before treatment were 36.21 with SD = 4.076 and after treatment were 37.17 with SD = 4.316. Home care with modern wound care: ozone bagging gave effect on wound healing of patients with diabetic foot ulcers (p = 0.026). All participants expressed feelings of great satisfaction. Therefore, it is necessary to develop further research, by developing design and intervention in several groups, so it can assess the effectiveness of ozone bagging for healing diabetic foot ulcers through home care.

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“…Diabetes mellitus (DM) is a major public health problem worldwide 9 . According to the International Diabetes Federation (IDF), the global prevalence of DM in 2011 was 366 million, but it is estimated that in 2030 DM will affect 552 million of people 9,10 . Therefore, it is reported ankle/tibial plafond fractures and diabetes mellitus are both increasing in prevalence 7 .…”

Section: Patient Comorbiditiesmentioning

confidence: 99%

Malunions and nonunions following tibial malleolar and tibial plafond fractures: current concepts

et al. 2020

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Ankle fractures or fracture-dislocations account for about 4-5% of all body fractures, with approximately 120-180/100,000 affected persons/year. Tibial pilon fractures are relatively infrequent, accounting for 5-7% of all fractures of the tibia. This review aims to summarize the current evidence on malunions and nonunions following tibial malleolar and tibial plafond fractures and to give some tips to avoid such complications. Malunion and nonunion following tibial malleolar and plafond fractures are quite rare but dreadful complications. Accurate evaluation of comorbidities and optimization of the patient's health should be done before surgery. Multiple recent retrospective studies have shown that ankle/ tibial plafond fractures treated within 72 h of surgery have comparable outcomes to staged fixation, the two-stage protocol is the most commonly used approach for the treatment of high-energy intra-articular injuries of the distal tibia. Several surgical approaches have been described for the management of ankle and tibial plafond fractures. Each one of these approaches has its own advantages and disadvantages, hence, it is important to recognize that no one approach is right for all patients. Surgeons managing these complex fractures should be comfortable with the various approaches to the distal tibia and be prepared to use whichever approach is suitable for the individual soft tissues and fracture pattern. Finally, with improvements in surgical techniques and implants, complication rates following ankle and tibial plafond fractures have declined, and outcomes have improved.

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Evidence based review of literature on detriments to healing of diabetic foot ulcers

Cited by 24 publications

References 104 publications

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

Home Care by Ozone Bagging towards Diabetic Foot Ulcers Healing

Malunions and nonunions following tibial malleolar and tibial plafond fractures: current concepts

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