Evidence for a bovine origin of the polyomaviurs detected in foetal rhesus monkey kidney cells, FRhK-4 and -6

Parry, J. V.; Lucas, MH; Richmond, J. E.; Gardner, S. D.

doi:10.1007/bf01311311

Cited by 23 publications

(16 citation statements)

References 13 publications

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“…Initial observations indicating a bovine rather than a monkey origin for these isolates came from two independent reports (Parry et al, 1983b;Wognum et al, 1984). These reports indicated that specific antibodies against these viral isolates were present in a high percentage of cattle sera and colostrum samples.…”

Section: Introductionmentioning

confidence: 99%

The Complete Nucleotide Sequence of Bovine Polyomavirus

Schuurman

Sol

Noordaa

1990

Journal of General Virology

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The complete sequence of the genome of bovine polyomavirus (BPyV), formerly known as the CK isolate of the stump-tailed macaque virus, is presented. The genomic organization of BPyV is similar to that of the non-rodent polyomaviruses. With a genome size of 4697 bp, BPyV has the smallest polyomavirus genome known so far. When compared to simian virus 40 (SV40), the shortness of the BPyV genome is due mainly to differences in the coding capacity of the BPyV early region. The first exon of the proposed large T antigen encodes only 35 amino acids; also, a coding region corresponding to the C-terminal 64 amino acids of the SV40 large T antigen is absent in BPyV. It is proposed that the nucleotide sequence encompassing the small t antigen coding sequence contains an intron sequence of 71 nucleotides. Together the two exon sequences encode a 124 amino acid protein. We conclude that this may be the first example of a polyomavirus that has a small t antigen which is translated from two exon sequences. The enhancer region of BPyV does not show homology to the SV40 enhancer sequences. An agnogene is present with a coding capacity of 118 amino acid residues. The highest degree of homology to SV40 and PyV is present in the VP1 molecule.

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Section: Introductionmentioning

confidence: 99%

The Complete Nucleotide Sequence of Bovine Polyomavirus

Schuurman

Sol

Noordaa

1990

Journal of General Virology

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“…BPyV sequences have been reported by diverse authors to be found in calf serum batches (24,32,38,39). Although antibodies have been detected in cattle (32,44) and in humans in close contact with cattle (31), no specific illness has been attributed to BPyV.…”

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confidence: 99%

Identification of Human and Animal Adenoviruses and Polyomaviruses for Determination of Sources of Fecal Contamination in the Environment

Hundesa

Motes

Bofill-Mas

et al. 2006

Appl Environ Microbiol

150

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The Adenoviridae and Polyomaviridae families comprise a wide diversity of viruses which may be excreted for long periods in feces or urine. In this study, a preliminary analysis of the prevalence in the environment and the potential usefulness as source-tracking tools of human and animal adenoviruses and polyomaviruses has been developed. Molecular assays based on PCR specifically targeting human adenoviruses (HAdV), porcine adenoviruses (PAdV), bovine adenoviruses (BAdV), and bovine polyomaviruses (BPyV) were applied to environmental samples including urban sewage, slaughterhouse, and river water samples. PAdV and BPyV were detected in a very high percentage of samples potentially affected by either porcine or bovine fecal contamination, respectively. However, BAdV were detected in only one sample, showing a lower prevalence than BPyV in the wastewater samples analyzed. The 22 slaughterhouse samples with fecal contamination of animal origin showed negative results for the presence of HAdV. The river water samples analyzed were positive for the presence of both human and animal adenoviruses and polyomaviruses, indicating the existence of diverse sources of contamination. The identities of the viruses detected were confirmed by analyses of the amplified sequences. All BPyV isolates showed a 97% similarity in nucleotide sequences. This is the first time that PAdV5, BAdV6, and BPyV have been reported to occur in environmental samples. Human and porcine adenoviruses and human and bovine polyomaviruses are proposed as tools for evaluating the presence of viral contamination and for tracking the origin of fecal/urine contamination in environmental samples.

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“…Monkeys are already known to be the hosts of three different polyomaviruses: simian virus 40 [15], simian agent 12 [1,7,17] and lymphotropic papovavirus (LPV) [19], and another possible source of a polyomavirus is fetal calf serum used in the culture medium [11]. Indeed the bovine polyomavirus has been found as an adventitious virus in a number of different cell lines derived from primate kidney cultures [ 11,12,18].…”

Section: Discussionmentioning

confidence: 99%

Characterization of a new polyomavirus (Polyomavirus papionis-2) isolated from baboon kidney cell cultures

Gardner¹,

Knowles²,

Hand³

et al. 1989

Archives of Virology

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Viruses with papovavirus morphology were seen in fluids from baboon kidney cell cultures on three separate occasions (isolates A, B, and C). The size of the virions, 47.9 nm, placed the virus in the polyomavirus genus. It grew well in baboon kidney and Vero cells and less well in human embryo lung (HEL) fibroblasts. The virus could not be identified as the previously described baboon polyomavirus, SA 12, or as any of the other known primate polyomaviruses BK, JC or SV 40, the non-primate viruses mouse polyoma, K, rabbit kidney vacuolating virus (RKV) or bovine polyomavirus (FRKV) by immunofluorescence, immune electron microscopy or hemagglutination inhibition (HI) tests. A rabbit antiserum to the new virus (isolate A) reacted only with the three isolates and not with the other primate polyomaviruses studied. Thirteen percent of 118 wild-caught baboons (Papio anubis) had HI antibody to the new polyomavirus and 21 percent were seropositive for SA 12; only two baboons had antibody to both viruses. These results suggest that in baboons there are two antigenically distinct polyomaviruses which circulate independently. The two viruses may also be distinguished by their hemagglutinating properties: SA 12 agglutinated erythrocytes from a wider range of species but only the newly recognized polyomavirus agglutinated baboon erythrocytes. We propose that the two baboon viruses, SA 12 and the new virus, should be named Polyomavirus papionis-1 and Polyomavirus papionis-2 respectively.

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Evidence for a bovine origin of the polyomaviurs detected in foetal rhesus monkey kidney cells, FRhK-4 and -6

Cited by 23 publications

References 13 publications

The Complete Nucleotide Sequence of Bovine Polyomavirus

The Complete Nucleotide Sequence of Bovine Polyomavirus

Identification of Human and Animal Adenoviruses and Polyomaviruses for Determination of Sources of Fecal Contamination in the Environment

Characterization of a new polyomavirus (Polyomavirus papionis-2) isolated from baboon kidney cell cultures

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